Results 41 to 50 of about 5,582 (252)

The future of atom probe tomography

Materials Today, 2012
The dream of the microscopy and materials science communities is to see, identify, accurately locate, and determine the fundamental physical properties of every atom in a specimen. With this knowledge together with modern computer models and simulations, a full understanding of the properties of a material can be determined.
Miller, Michael K., Kelly, Thomas. F., Rajan, Krishna, Ringer, Simon P.   +3 more
openaire   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Quantitative analysis of hydrogen in SiO2/SiN/SiO2 stacks using atom probe tomography

AIP Advances, 2016
We have demonstrated that it is possible to reproducibly quantify hydrogen concentration in the SiN layer of a SiO2/SiN/SiO2 (ONO) stack structure using ultraviolet laser-assisted atom probe tomography (APT).
Yorinobu Kunimune, Yasuhiro Shimada, Yusuke Sakurai, Masao Inoue, Akio Nishida, Bin Han, Yuan Tu, Hisashi Takamizawa, Yasuo Shimizu, Koji Inoue, Fumiko Yano, Yasuyoshi Nagai, Toshiharu Katayama, Takashi Ide   +13 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Precipitation‐Modulated Harmonic Architectures Enable Superior Strength–Ductility Synergy from Cryogenic to Elevated Temperatures in Nanostructured Alloys

Advanced Science
High‐performance materials that exhibit a robust strength–ductility synergy across cryogenic to high temperatures are essential for aerospace applications, yet achieving this combination remains a significant challenge in materials development.
Wei Li, Liangyin Xiong, Mengchao Niu, Junhua Luan, Wei Wang, Zengbao Jiao   +5 more
doaj   +1 more source

Deformation-induced trace element redistribution in zircon revealed using atom probe tomography

Nature Communications, 2016
Pb/U ratios and trace element distributions within zircon grains are used to determine a rock's age and geological processes, but the degree of element immobility and diffusion is uncertain.
Sandra Piazolo, Alexandre La Fontaine, Patrick Trimby, Simon Harley, Limei Yang, Richard Armstrong, Julie M. Cairney   +6 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Direct atomic insight into the role of dopants in phase-change materials

Nature Communications, 2019
Quantitative imaging on the doping in phase-change materials for data storage remains scarce. Here, the authors combine electron microscopy, atom probe tomography, and simulations to determine the role of indium and silver dopants during ...
Min Zhu, Wenxiong Song, Philipp M. Konze, Tao Li, Baptiste Gault, Xin Chen, Jiabin Shen, Shilong Lv, Zhitang Song, Matthias Wuttig, Richard Dronskowski   +10 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Characterization of Sub-Monolayer Contaminants at the Regrowth Interface in GaN Nanowires Grown by Selective-Area Molecular Beam Epitaxy

Crystals, 2018
While GaN nanowires (NWs) offer an attractive architecture for a variety of nanoscale optical, electronic, and mechanical devices, defects such as crystal polarity inversion domains (IDs) can limit device performance.
Paul Blanchard, Matt Brubaker, Todd Harvey, Alexana Roshko, Norman Sanford, Joel Weber, Kris A. Bertness   +6 more
doaj   +1 more source