Results 31 to 40 of about 197,633 (265)
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Determination of Arsenic in Dust fall in the Air of Yazd Zahra Soltanianzadeh, Mohammad Hossein Salmani, Mohammad Hassan Ehrampoush [PDF]
شیمی کاربردی روز, 2010 Human can live without food and water for many days but they can not live without breathing Air more than a few minutes. Then, Air Pollution is a Problem that additional must attended. Many countries have developed search work and Programs to Control air
Zahra Soltanianzadeh +2 more
doaj +1 more source
Automated Atomic Absorption Spectrophotometry
Clinical Chemistry, 1973 Abstract Diluting continuous-flow circuits that incorporate a jet mixer with conventional AutoAnalyzer equipment provide a convenient technique for supplying diluted samples to an atomic absorption spectrophotometer at rates up to 90 per hour.
H J, Gitelman, C, Soucek, J F, Owen
openaire +2 more sources
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
NutraceuticalsThe phytonutraceutical Ormona® is a product composed of purified oil of Bixa orellana Linné, dry extract of Myrciaria dubia McVaugh, dry extract of Trifolium pratense L., and dry extract of Euterpe oleracea Mart. obtained using Evolve® technology.
Aline Lopes do Nascimento +10 more
doaj +1 more source
Spatial and species-specific features of trace element accumulation in commercial fish of the Sea of Okhotsk [PDF]
Геосистемы переходных зонThe northwestern Pacific Ocean is characterized by unique geochemical conditions that promote elevated trace element accumulation in marine organisms of the region.
Shestera, Andrey A. +8 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Serum and Urine Copper – Contamination and Stability
Acta Medica Bulgarica, 2015 Pre-analytical factors of variation need to be carefully considered and investigated in efforts to harmonize all aspects of the total testing process. This study aimed to evaluate contamination and stability in copper (Cu) analysis of serum and urine by ...
Dimitrova Ivanova I. +7 more
doaj +1 more source
Spanish Journal of Agricultural Research, 2020 Aim of study: To evaluate the effect of cultivar and year of harvest on the content of mineral elements of Algerian extra virgin olive oils. Area of study: Technical Institute of Arboriculture of Fruits and Vine (TIAFV), Bejaia, Algeria.
Karima Benamirouche-Harbi +4 more
doaj +1 more source