Results 111 to 120 of about 6,623 (297)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
New frequency ratios with a PHz-scale atomic clock
New Journal of Physics, 2016 Atomic clocks are a tour de force when it comes to rigorous tests of measurement. The ultimate validation of one’s careful assessments is to find agreement on a given parameter with a completely independent laboratory.
J J McFerran
doaj +1 more source
The ac stark shift and space-borne rubidium atomic clocks [PDF]
, 2016 Valerio Formichella +6 more
openalex +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Collinear Three-Photon Excitation of a Strongly Forbidden Optical Clock Transition
Physical Review XThe ^{1}S_{0}-^{3}P_{0} clock transition in strontium serves as the foundation for the world’s best atomic clocks and for gravitational wave detector concepts in clock atom interferometry.
Samuel P. Carman +9 more
doaj +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Man with atomic clock developed at NBS [PDF]
This image is part of the Atomic Clock collection. The Atomic Clock collection is comprised of images documenting the development of the atomic clocks that were part of the National Bureau of Standards (NBS) Atomic Time System.
National Institute of Standards and Technology and Technology
core
A Compact Optical Clock Scheme Based on Caesium Atomic Beam [PDF]
, 2016 We report a compact optical clock scheme based on caesium (Cs) atomic beam, which extends the application of Cs from microwave frequency standard to optical frequency standard. Considering the 1.2 MHz narrow natural-linewidth of the excited state 7P(1/2)
Duo Pan +15 more
core +1 more source
Observation of mHz-level cooperative Lamb shifts in an optical atomic clock [PDF]
, 2023 Ross B. Hutson +4 more
openalex +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source