Results 91 to 100 of about 6,623 (297)

Reducing the Instability of an Optical Lattice Clock Using Multiple Atomic Ensembles

open access: yesPhysical Review X
The stability of an optical atomic clock is a critical figure of merit for almost all clock applications. To this end, much optical atomic clock research has focused on reducing clock instability by increasing the atom number, lengthening the coherent ...
Xin Zheng   +2 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

open access: yesFEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach

open access: yesFEBS Letters, EarlyView.
The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring   +3 more
wiley   +1 more source

David J. Glaze with the NBS-6 Atomic Clock [PDF]

open access: yes, 1978
National Bureau of Standards Physicist David J. Glaze was one of the principal builders of the NBS time and frequency standard NBS-6. He also worked on several of the preceding five generations of NBS atomic clocks.
National Institute of Standards and Technology and Technology
core  

A Transportable Calcium Atomic Beam Optical Clock [PDF]

open access: yes, 2016
Achievement on atomic optical clock, which has reached to 10(-18) level uncertainty, accelerates the research of the fundamental physics. But enormous volume size limits the application of optical clock outside the lab.
Zhang, Xiaogang   +17 more
core   +1 more source

Lindblad decoherence in atomic clocks

open access: yesPhysical Review A, 2016
It is shown how possible corrections to ordinary quantum mechanics described by the Lindblad equation might be detected by exploiting the great precision of atomic clocks.
openaire   +3 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Atomic clock at NBS [PDF]

open access: yes
This image is part of the Atomic Clock collection. The Atomic Clock collection is comprised of images documenting the development of the atomic clocks that were part of the National Bureau of Standards (NBS) Atomic Time System.
National Institute of Standards and Technology and Technology
core  

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