Results 81 to 90 of about 613,647 (384)

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Tip–sample interactions: Extraction of single molecular pair potentials from force curves [PDF]

, 1996
This article describes a method for extracting the true tip–sample potential from an experimental force curve in atomic force microscopy. This potential is not the negative integral of the force curve. Rather, the potential is a more complicated function
Baldeschwieler, John D., O'Connor, Stephen D., Unger, Marc A.   +2 more
core   +1 more source

Force Microscopy with Light-Atom Probes [PDF]

Science, 2004
The charge distribution in atoms with closed electron shells is spherically symmetric, whereas atoms with partially filled shells can form covalent bonds with pointed lobes of increased charge density. Covalent bonding in the bulk can also affect surface atoms, leading to four tiny humps spaced by less than 100 picometers in the charge density of ...
Hembacher, Stefan, Giessibl, Franz J., Mannhart, Jochen   +2 more
openaire   +4 more sources

Co‐overexpression of the caloric restriction‐induced mitochondrial factors PGC‐1α and MIPEP upregulates Phospho1 expression in adipocytes

FEBS Open Bio, EarlyView.
Caloric restriction that extends lifespan induces the expression of PGC‐1α and MIPEP in white adipose tissue. In this study, co‐overexpression of Pgc‐1α and Mipep upregulated the gene expression of PHOSPHO1. These findings provide new insights into mitochondria‐related mechanisms underlying the effects of caloric restriction in adipocytes.
Mamiko Ishimatsu, Kanari Taki, Asuka Hayami, Komachi Kato, Yuka Nozaki, Yuhei Mizunoe, Takumi Narita, Ryoichi Mori, Yoshikazu Higami, Masaki Kobayashi   +9 more
wiley   +1 more source

Multifunctional hydrogel nano-probes for atomic force microscopy

Nature Communications, 2016
Atomic force microscopy typically employs hard tips to map the surface topology of a sample, with sub-nanometre resolution. Here, the authors instead develop softer hydrogel probes, which show potential for multifunctional measurement capabilities beyond
Jae Seol Lee, Jungki Song, Seong Oh Kim, Seokbeom Kim, Wooju Lee, Joshua A. Jackman, Dongchoul Kim, Nam-Joon Cho, Jungchul Lee   +8 more
doaj   +1 more source

Array atomic force microscopy for real-time multiparametric analysis. [PDF]

, 2019
Nanoscale multipoint structure-function analysis is essential for deciphering the complexity of multiscale biological and physical systems. Atomic force microscopy (AFM) allows nanoscale structure-function imaging in various operating environments and ...
Azam, Farooq, Cauwenberghs, Gert, Head, Brian P, Herum, Kate M, John, Scott, Lal, Ratnesh, Lee, Joon, Liu, Zhaowei, Lo, Yu-Hwa, Ma, Qian, McCulloch, Andrew D, Patel, Nirav, Tang, Hanmei, Wang, Chonghe, Wang, Jun, Wang, Shanshan, Xu, Sheng, Yang, Qingqing, Yen, Tony M   +18 more
core   +1 more source

Atomic Force Microscopy of Biological Membranes [PDF]

Biophysical Journal, 2009
Atomic force microscopy (AFM) is an ideal method to study the surface topography of biological membranes. It allows membranes that are adsorbed to flat solid supports to be raster-scanned in physiological solutions with an atomically sharp tip. Therefore, AFM is capable of observing biological molecular machines at work.
Patrick D. Bosshart, P. L. T. M. Frederix, Andreas Engel, Andreas Engel   +3 more
openaire   +3 more sources

Hyperoxia Induced Alteration of Chromatin Structure in Human Bone Marrow Derived Primary Mesenchymal Stromal Cells

Advanced Biology, EarlyView.
Chromatin, which organizes DNA, changes its structure to adapt to stress like high oxygen levels (hyperoxia), which can damage cells. Researchers developed a technique to observe these changes and found variability in how different parts of chromatin remodel.
Lauren Monroe, Samantha Kaonis, Natalie Calahan, Neda Kabi, Soham Ghosh   +4 more
wiley   +1 more source

Force-gradient-induced mechanical dissipation of quartz tuning fork force sensors used in atomic force microscopy

, 2011
We have studied the dynamics of quartz tuning fork resonators used in atomic force microscopy taking into account mechanical energy dissipation through the attachment of the tuning fork base.
A. Castellanos-Gomez, Albers, Castellanos-Gomez, Castellanos-Gomez, Cleveland, Edwards, G. Rubio-Bollinger, Giessibl, Giessibl, Grober, Ihn, Karrai, le Sueur, N. Agraït, Naber, Ng, Oral, Rensen, Rubio-Bollinger, Seo, Shelimov, Smit, Valkering   +22 more
core   +1 more source

LIN28B Promotes Cancer Cell Dissemination and Angiogenesis

Advanced Biology, EarlyView.
Children diagnosed with high‐risk neuroblastoma have a 5‐year event‐free survival rate of less than 50% and poor outcomes after recurrence. Deregulation of the LIN28B oncogene can be addressed in these patients. Upregulation of LIN28B is shown to support the metastatic cascade.
Diana Corallo, Sara Menegazzo, Marcella Pantile, Silvia Bresolin, Carlo Zanon, Alessandro Davini, Massimiliano Mazzone, Alessandra Biffi, Sanja Aveic   +8 more
wiley   +1 more source