Results 41 to 50 of about 160,582 (294)

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

Progress of Jinping Underground laboratory for Nuclear Astrophysics (JUNA)

EPJ Web of Conferences, 2016
Jinping Underground lab for Nuclear Astrophysics (JUNA) will take the advantage of the ultralow background in Jinping underground lab, high current accelerator based on an ECR source and highly sensitive detector to study directly a number of crucial ...
Liu WeiPing, Li ZhiHong, He JiangJun, Tang XiaoDong, Lian Gang, An Zhu, Chang JianJun, Chen Han, Chen QingHao, Chen XiongJun, Chen ZhiJun, Cui BaoQun, Du XianChao, Fu ChangBo, Gan Lin, Guo Bing, He GuoZhu, Heger Alexander, Hou SuQing, Huang HanXiong, Huang Ning, Jia BaoLu, Jiang LiYang, Kubono Shigeru, Li JianMin, Li KuoAng, Li Tao, Li YunJu, Lugaro Maria, Luo XiaoBing, Ma HongYi, Ma ShaoBo, Mei DongMing, Qian YongZhong, Qin JiuChang, Ren Jie, Shen YangPing, Su Jun, Sun LiangTing, Tan WanPeng, Tanihata Isao, Wang Shuo, Wang Peng, Wang YouBao, Wu Qi, Xu ShiWei, Yan ShengQuan, Yang LiTao, Yang Yao, Yu XiangQing, Yue Qian, Zeng Sheng, Zhang HuanYu, Zhang Hui, Zhang LiYong, Zhang NingTao, Zhang QiWei, Zhang Tao, Zhang XiaoPeng, Zhang XueZhen, Zhang ZiMing, Zhao Wei, Zhao Zuo, Zhou Chao   +63 more
doaj   +1 more source

Comprehensive Review on the Impact of Artificial Intelligence on Diagnosis and Personalized Treatment in Nuclear Medicine [PDF]

SHS Web of Conferences
Artificial intelligence (AI) continues to advance nuclear medicine in all areas, including treatment planning, resource allocation, and precision. The imaging techniques powered by AI enable faster and more accurate diagnosis of diseases and machine ...
Arhouni Fatima Ezzahra, Zitouni Ilias, Ouakkas Saad, Abdo Maged Ahmed Saleh, Boukhair Aziz, Bouhssa Mohamed Lhadi, Bouanis Marya, Fahad Mohammed   +7 more
doaj   +1 more source

Short-Range Charge Transfer in DNA Base Triplets: Real-Time Tracking of Coherent Fluctuation Electron Transfer

Molecules, 2023
The short-range charge transfer of DNA base triplets has wide application prospects in bioelectronic devices for identifying DNA bases and clinical diagnostics, and the key to its development is to understand the mechanisms of short-range electron ...
Lixia Zhu, Qi Li, Yongfeng Wan, Meilin Guo, Lu Yan, Hang Yin, Ying Shi   +6 more
doaj   +1 more source

ACSS2 involved in acetyl‐CoA synthesis regulates skeletal muscle function

FEBS Letters, EarlyView.
The enzyme acyl‐coenzyme A synthetase short‐chain family member‐2 (ACSS2) catalyzes the conversion of acetate to acetyl‐CoA, but its function in skeletal muscle is unclear. We studied ACSS2 deficiency in mouse and fly models. Skeletal muscle from the mouse model showed atrophic fibers, excess lipid, and depleted NADH.
Mekala Gunasekaran, Gloriana Campos, Natalya M. Wells, Khanhlinh Lambuu, Isabelle Draper, Christina A. Pacak, Peter B. Kang   +6 more
wiley   +1 more source

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

FEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke, Nils Alexander Lakomek, Georg Groth   +2 more
wiley   +1 more source

Design and development of DC to DC voltage booster to integrate with PbTe/TAGS-85 based thermoelectric power generators

Materials Science for Energy Technologies, 2019
Thermoelectric power generators (TEGs) based on Seebeck effect convert waste heat into electricity. However, the practical applications of such TEGs are limited by their low output DC voltage (10–300 mV).
S.K. Sahu, Anil K. Bohra, P.G. Abichandani, Ajay Singh, Shovit Bhattacharya, Ranu Bhatt, Ranita Basu, Pritam Sarkar, S.K. Gupta, K.P. Muthe, S.C. Gadkari   +10 more
doaj   +1 more source

Physical Limits on Atomic Resolution

Microscopy and Microanalysis, 2004
It is shown that the ultimate resolution is not limited by the bandwidth of the microscope but by the bandwidth (i.e., the scattering power) of the object. In the case of a crystal oriented along a zone axis, the scattering is enhanced by the channeling of the electrons.
Van Dyck, D. (author), Van Aert, S. (author), Den Dekker, A.J. (author)   +2 more
openaire   +6 more sources

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Strongly Bound Frenkel Excitons on TiO2 Nanoparticles: An Evolutionary and DFT Approach

International Journal of Photoenergy
An evolutionary algorithm was employed to locate the global minimum of TiO2n nanoparticles with n=2–20. More than 61,000 structures were calculated with a semiempirical method and reoptimized using density functional theory. The exciton binding energy of
Oscar Olvera-Neria, Raúl García-Cruz, Julio Gonzalez-Torres, Luz María García-Cruz, Jean Luis Castillo-Sánchez, Enrique Poulain   +5 more
doaj   +1 more source