Results 51 to 60 of about 3,187,089 (301)

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Atomic physics using short-wavelength coherent radiation

, 1997
Laser spectroscopy of free atoms has been pursued for 25 years starting in the visible region and with a constant thrust towards shorter wavelengths. A review of generation schemes and atomic-physics experiments in the short-wavelength region is given ...
Wahlström, Claes-Göran, Svanberg, Sune, Sune Svanberg, Anne L'Huillier, Claes-Göran Wahlström, L'Huillier, Anne, Svanberg, Sune,, L'Huillier, Anne,, Wahlström, Claes-Göran,, Lund University.   +9 more
core   +1 more source

Efficient generation of Bessel-Gauss attosecond pulse trains via nonadiabatic phase-matched high-order harmonics

Light: Science & Applications
Generating Bessel-Gauss beams in the extreme ultraviolet (EUV) with attosecond pulse durations poses a significant challenge due to the limitations of conventional transmission optical components.
Mingxuan Li, Xiangyu Tang, Huiyong Wang, Jialong Li, Wentao Wang, Jiaao Cai, Jieda Zhang, Xinyue San, Xinning Zhao, Pan Ma, Sizuo Luo, Cheng Jin, Dajun Ding   +12 more
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Investigation into the radioactivity of various natural and anthropogenic radionuclides in marine sediments from the Sudanese coastline of the Red Sea

Scientific Reports
A total of sixty surface sediment samples were systematically obtained from ten distinct locations along the Sudanese coastline of the Red Sea during the summer season (June 2016) and the winter season (February 2017), subsequently analyzed using high ...
Elshafeea Abowslama, Mohamed Eltayeb, Khalid Elmamoun Ibrahim, Tarig Elshaarani, Mossap Babikir, Ekrami Osman, Gosai Abdelgader, Nuha Tarig, Nasreen Hassan, Mashaer Khalied, Fatima Elbasheer, Mohammed AbdulRahman, Alfatih Osman   +12 more
doaj   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Atomic Floquet physics revealed by free electrons

Physical Review Research, 2022
We theoretically investigate the ability of free electrons to yield information on the nonlinear Floquet dynamics of atomic systems subject to intense external illumination.
Eduardo Arqué López, Valerio Di Giulio, F. Javier García de Abajo   +2 more
doaj   +1 more source

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

FEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim, Thi Thanh Mai Tran, Nakyung Kang, Min‐Woo Lee, Mihye Lee   +4 more
wiley   +1 more source