Results 51 to 60 of about 179,289 (254)

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Investigation into the radioactivity of various natural and anthropogenic radionuclides in marine sediments from the Sudanese coastline of the Red Sea

Scientific Reports
A total of sixty surface sediment samples were systematically obtained from ten distinct locations along the Sudanese coastline of the Red Sea during the summer season (June 2016) and the winter season (February 2017), subsequently analyzed using high ...
Elshafeea Abowslama, Mohamed Eltayeb, Khalid Elmamoun Ibrahim, Tarig Elshaarani, Mossap Babikir, Ekrami Osman, Gosai Abdelgader, Nuha Tarig, Nasreen Hassan, Mashaer Khalied, Fatima Elbasheer, Mohammed AbdulRahman, Alfatih Osman   +12 more
doaj   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Three-dimensional sizes and shapes of pion emission in heavy-ion collisions

European Physical Journal C: Particles and Fields
In the era of precision measurements in high-energy heavy-ion physics, there is an increasing expectation towards phenomenological and theoretical studies to provide a better description of data.
Dániel Kincses, Emese Árpási, László Kovács, Márton Nagy, Máté Csanád   +4 more
doaj   +1 more source

Water ice formation beyond its sublimation temperature in ultrahigh vacuum conditions-implications to astrochemical ices [PDF]

EPJ Web of Conferences
Water ice is the most abundant ice in the interstellar medium, typically sublimating around 180 K under astrochemical conditions. This restricts its condensation and stability to the cold outer regions of protoplanetary disks beyond the water snowline ...
Khan Wafikul, Ramachandran Ragav, Krishna Meka Jaya, Gupta Shivanshi, Padmanabhan Janardhan, Bhardwaj Anil, John Mason Nigel, Sivaraman Bhalamurugan   +7 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A persistent radon anomaly signal preceding the destructive 7.7 Mw earthquake in Myanmar on March 28, 2025

Scientific Reports
On March 28, 2025, a devastating earthquake doublet of moment magnitude 7.7 and 6.7 struck the Sagaing Region of Myanmar, causing extensive damage and significant casualties across Southeast Asia.
B. K. Sahoo, B. K. Sapra, Arshad Khan, M. P. Ratheesh, D. H. Kumbhar, J. J. Gaware, S. D. Kanse, Sumitra Phanjoubam, D. K. Aswal   +8 more
doaj   +1 more source