Results 31 to 40 of about 144,255 (267)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Method of statistical data processing safety ecological monitoring combined heat and power station in the megalopolis territory

open access: yesMATEC Web of Conferences, 2016
The first developed method allowed to determine the combined effects of emissions of pollutants into the atmospheric air in the city by combined heat and power stations group, as well as to assess the interference impact of combined heat and power ...
Telichenko Valeriy   +2 more
doaj   +1 more source

Remaining and emerging issues pertaining to the human reliability analysis of domestic nuclear power plants

open access: yesNuclear Engineering and Technology, 2019
Probabilistic safety assessments (PSA) have been used for several decades to visualize the risk level of commercial nuclear power plants (NPPs). Since the role of a human reliability analysis (HRA) is to provide human error probabilities for safety ...
Jinkyun Park   +6 more
doaj   +1 more source

Non-hardening embrittlement mechanism of pressure vessel steel Ni-Cr-Mo-V welds during thermal aging

open access: yesAdvances in Mechanical Engineering, 2020
The mechanical performance of reactor pressure vessel materials is an important factor in the safety and economics of the operation of a nuclear power plant.
Guojun Wei   +4 more
doaj   +1 more source

Biophysical approaches for studying viral entry

open access: yesFEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Analysis of particles containing alpha-emitters in stagnant water at torus room of Fukushima Dai-ichi Nuclear Power Station’s Unit 2 reactor

open access: yesScientific Reports, 2022
Particles containing alpha (α) nuclides were identified from sediment in stagnant water in the torus room of the Fukushima Dai-ichi Nuclear Power Station(FDiNPS)’s Unit 2 reactor.
Takumi Yomogida   +5 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

SOME ISSUES OF THE OBJECTIVE PART OF CORPUS DELICTI IN THE SAFETY NORMS VIOLATION ON THE ATOMIC POWER OBJECTS

open access: yesRussian Journal of Economics and Law, 2007
The article is dedicated to the analysis of certain signs of the objective part of corpus delicti of the safety regulations violations at the atomic power objects: the deed, its consequences, casual relations between them, crime scene.
R. R. Fazylov
doaj  

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