Results 171 to 180 of about 26,804,949 (344)

Atomic Energy Commission Report KAPL-2000-21

open access: yes, 1964
Quarterly report issued by the Knolls Atomic Power Laboratory to report to the industry on developments in unclassified reactor technology.

core  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Atomic Energy Commission Report SO-45

open access: yes, 1959
Preface: In 1948, the U.S. Geological Survey, in cooperation with the Atomic Energy Commission, initiated a study of the hydraulics and hydrology of Mohawk River in the vicinity of the Knolls Atomic Power Laboratory (KAPL) near Schenectady, N.Y.
Beetem, W. A.   +2 more
core  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

open access: yesMolecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim   +11 more
wiley   +1 more source

Atomic Energy Commission Report KAPL-2000-10

open access: yes, 1960
Quarterly report issued by the Knolls Atomic Power Laboratory to report to the industry on developments in unclassified reactor technology.

core  

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