Results 71 to 80 of about 12,070 (266)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
MetalsHybrid atomization represents a novel method for powder production with high cooling and crushing capacities, but previous studies have primarily focused on tin and aluminum alloy systems. In present study, FeSiBNbCu nanocrystalline powders were prepared
Huan Chen +7 more
doaj +1 more source
Effects of inclination of nozzle holes for direct injection Diesel engine on spray characteristics
Nihon Kikai Gakkai ronbunshu, 2017 This paper describes about improvement of spray characteristics of the nozzle for a direct injection Diesel nozzle, which excellent spray characteristics is obtained.
Nobushige TAMAKI, Kazuma NISHIKAWA
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Mini-review: air-assisted spray nozzles and applications
Frontiers in PhysicsThis mini-review summarizes the fundamental principle, spray phenomena, and atomization mechanism of air-assisted spray nozzles, and applications in various aerospace propulsion systems, agriculture irrigation, and some promising areas.
Yuanfeng Zhao +3 more
doaj +1 more source
Nihon Kikai Gakkai ronbunshu, 2018 Reduction of particulate matter (PM) in exhaust gas from automobile engines is in high demand. Fuel stuck on the engine wall causes incomplete combustion, and generates a large amount of PM.
Kazuki YOSHIMURA +5 more
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Journal of Thermal Science and Technology, 2009 The purpose of this paper is to investigate the effect of the ambient pressure on the overall spray characteristics of dimethyl ether (DME) and biodiesel fuel spray in a high-pressure combustion chamber.
Hyung Jun KIM +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source