Results 111 to 120 of about 38,860 (304)

Rate of an Atomic Clock in Motion [PDF]

Nature, 1938
ACCORDING to the theory of the relation between matter and the luminiferous ether, as developed by Larmor and Lorentz, a moving clock should assume the rate where v0 is the stationary rate, V the measured velocity of the clock with respect to the observer, and c the velocity of light.
openaire   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Design and experimental research of air-assisted nozzle for pesticide application in orchard

Frontiers in Plant Science
This article reports the design and experiment of a novel air-assisted nozzle for pesticide application in orchard. A novel air-assisted nozzle was designed based on the transverse jet atomization pattern.
Mingxiong Ou, Jiayao Zhang, Wentao Du, Minmin Wu, Tianyu Gao, Weidong Jia, Xiang Dong, Tie Zhang, Suming Ding   +8 more
doaj   +1 more source

Scattered-light scanner measurements of cryogenic liquid-jet breakup [PDF]

The effect of highly turbulent Mach 1 gas flow and high thermal gradients on drop size measurements was investigated with a scattered light scanner. The instrument, developed at NASA-Lewis, was used to measure characteristic drop diameters or cyrogenic ...
Buchele, Donald R., Ingebo, Robert D.
core   +1 more source

Global hybrids from the semiclassical atom theory satisfying the local density linear response

, 2014
We propose global hybrid approximations of the exchange-correlation (XC) energy functional which reproduce well the modified fourth-order gradient expansion of the exchange energy in the semiclassical limit of many-electron neutral atoms and recover the ...
Adamo C., Arbuznikov A. V., Arbuznikov A. V., Arbuznikov A. V., Arbuznikov A. V., Armiento R., Becke A. D., Becke A. D., Becke A. D., Becke A. D., Becke A. D., Biczysko M., Bremond E., Bühl M., Cancio A. C., Chiodo L., Cohen A. J., Constantin L. A., Constantin L. A., Constantin L. A., Constantin L. A., Constantin L. A., Constantin L. A., Constantin L. A., Constantin L. A., Cortona P., Curtiss L. A., del Campo J. M., del Campo J. M., del Campo J. M., Dickson R. M., Eduardo Fabiano, Elliott P., Ernzerhof M., Fabiano E., Fabiano E., Fabiano E., Fabiano E., Fabiano E., Fabiano E., Fabio Della Sala, Furche F., Goerigk L., Goerigk L., Grabowski I., Grabowski I., Grimme S., Grimme S., Guido C. A., Guido C. A., Guido C. A., Görling A., Haunschild R., Haunschild R., Haunschild R., Haunschild R., Haunschild R., Haunschild R., Hermet J., Hohenberg P., Horowitz C. M., Huang Y.-W., Iikura H., Janesko B. G., Johnson E. R., Johnson E. R., Jurečka P., Karton A., Kohn W., Krieger J. B., Lee C., Lee D., Lucian A. Constantin, Luo S., Lynch B. J., Lynch B. J., Marshall M. S., Martin J. M. L., Mattsson A. E., Mori-Sánchez P., Moroni S., Odashima M. M., Ortiz G., Paier J., Parthiban S., Perdew J. P., Perdew J. P., Perdew J. P., Perdew J. P., Perdew J. P., Perdew J. P., Peverati R., Pietro Cortona, Pittalis S., Ruzsinszky A., Schwabe T., Seidl M., Seidl M., Sharkas K., Staroverov V. E., Stephens P. J., Sun J., Tao J., Tognetti V., Tognetti V., Tognetti V., Tognetti V., Vydrov O. A., Weigend F., Weigend F., Zhao Y., Zhao Y., Zhao Y., Zhao Y., Zhao Y., Zhao Y., Zhao Y., Zhao Y.   +117 more
core   +5 more sources

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Combustion instability coupling with feed system acoustics [PDF]

High frequency combustion instability has recently been observed by Rocketdyne in a 40K thrust methane/LOX combustion chamber. The oscillations had frequencies as high as 14,000 Hz with pressure amplitudes in the LOX dome of 500 psi at a chamber ...
Breisacher, Kevin J., Priem, Richard J.
core   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source