Results 51 to 60 of about 65,128 (311)

Disrupting ceramide-CD300f interaction prevents septic peritonitis by stimulating neutrophil recruitment

Scientific Reports, 2017
Sepsis is a serious clinical problem. Negative regulation of innate immunity is associated with sepsis progression, but the underlying mechanisms remains unclear. Here we show that the receptor CD300f promotes disease progression in sepsis.
Kumi Izawa, Akie Maehara, Masamichi Isobe, Yuka Yasuda, Makoto Urai, Yasutaka Hoshino, Keigo Ueno, Toshihiro Matsukawa, Mariko Takahashi, Ayako Kaitani, Emiko Shiba, Ayako Takamori, Shino Uchida, Koichiro Uchida, Keiko Maeda, Nobuhiro Nakano, Yoshinori Yamanishi, Toshihiko Oki, David Voehringer, Axel Roers, Susumu Nakae, Junko Ishikawa, Yuki Kinjo, Toshiaki Shimizu, Hideoki Ogawa, Ko Okumura, Toshio Kitamura, Jiro Kitaura   +27 more
doaj   +1 more source

Characterization of pediatric eosinophilic gastrointestinal disorders beyond eosinophilic esophagitis in a nationwide cohort

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Nonesophageal eosinophilic gastrointestinal disorders (non‐EoE EGIDs) are rare, underrecognized inflammatory diseases of the gastrointestinal (GI) tract, especially in children. Their clinical heterogeneity and lack of specific biomarkers contribute to diagnostic delays and therapeutic challenges.
Sara Renzo, Luca Scarallo, Selene Del Vespa, Giulia Angelino, Matteo Bramuzzo, Enrico Felici, Flavio Labriola, Francesca Laganà, Lorenzo Norsa, Salvatore Oliva, Marisa Piccirillo, Elena Pozzi, Francesca Rea, Giusy Russo, Francesco Valitutti, Giovanna Zuin, Paolo Lionetti   +16 more
wiley   +1 more source

The interaction between the skin microbiome and antimicrobial peptides within the epidermal immune microenvironment: Bridging insights into atopic dermatitis

Allergology International
The epidermal immune microenvironment is a multifaceted system in which the interplay between the skin microbiome and antimicrobial peptides plays a pivotal role in sustaining skin homeostasis and preventing dysbiosis.
Shan Wang, Ge Peng, Alafate Abudouwanli, Mengyao Yang, Quan Sun, Wanchen Zhao, Arisa Ikeda, Yi Tan, Lin Ma, Hideoki Ogawa, Ko Okumura, François Niyonsaba   +11 more
doaj   +1 more source

Clock-dependent temporal regulation of IL-33/ST2-mediated mast cell response

Allergology International, 2017
Background: Interleukin-33 (IL-33) is an alarmin cytokine that binds to the interleukin 1 receptor-like 1 protein ST2. Clock is a key circadian gene that is essential for endogenous clockworks in mammals.
Takahiro Kawauchi, Kayoko Ishimaru, Yuki Nakamura, Nobuhiro Nakano, Mutsuko Hara, Hideoki Ogawa, Ko Okumura, Shigenobu Shibata, Atsuhito Nakao   +8 more
doaj   +1 more source

Exhaled Nitric Oxide is Not a Biomarker for Pulmonary Tuberculosis. [PDF]

, 2018
To reduce transmission of tuberculosis (TB) in resource-limited countries where TB remains a major cause of mortality, novel diagnostic tools are urgently needed.
Aston, Barnes, Chan, Daniel Pastorius, Daniel Smith, Dweik, Eduardo Ticona, Elmasri, Idh, Jon S. Friedland, José W. López, Karina M. Romero, Kim, Lim, Luz Caviedes, Maria-Cristina I. Loader, Marjory Bravard, Moore, Olin, O’Garra, Ralph, Ralph, Robert H. Gilman, Schon, Taryn Clark, Van Beek, Wang, William Checkley, Yhi   +28 more
core   +1 more source

Recovery from symptoms using an extensively hydrolyzed formula with synbiotic in infants with presumed cow's milk allergy

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objective Extensively hydrolyzed formulas (eHF) are the first‐line approach for cow's milk protein allergy (CMPA). This study evaluated the effects of eHF with synbiotic eHF (SeHF) on the general condition and symptoms of presumed CMPA infants during the initial 4‐week exclusion diet period.
Anaïs Lemoine, Florence Villard‐Truc, Imene Ait Mohamed Amar, François Payot   +3 more
wiley   +1 more source

Immunopharmacological potential of Arctium lappa L. in immune-mediated skin diseases: A critical review of experimental and clinical evidence

Frontiers in Pharmacology
BackgroundArctium lappa L. (A. lappa) has been used in traditional medicine worldwide and is increasingly being investigated for its immunomodulatory and anti-inflammatory effects.
Mengyao Yang, Mengyao Yang, Ge Peng, Alafate Abudouwanli, Shan Wang, Shan Wang, Quan Sun, Wanchen Zhao, Yi Tan, Xuefei Du, Li Zhang, Li Zhang, Hideoki Ogawa, Ko Okumura, Xinghua Gao, François Niyonsaba, François Niyonsaba   +16 more
doaj   +1 more source

Ambient particulate pollution and the world-wide prevalence of asthma, rhinoconjunctivitis and eczema in children: Phase One of the International Study of Asthma and Allergies in Childhood (ISAAC) [PDF]

, 2010
Objectives: To investigate the effect of ambient particulate matter on variation in childhood prevalence of asthma, rhinoconjunctivitis and eczema.
Anabwani, G., Anderson, H. R., Asher, M. I., Aït-Khaled, N., Beasley, R., Björkstén, B., Brunekreef, B., Burr, M. L., Clayton, T. O., Crane, J., Ellwood, P., Kapetanakis, V., Keil, U., Lai, C. K. W., Mallol, J., Martinez, F. C., Mitchell, E. A., Montefort, S., Mutius, Erika von, Pandey, K.D., Pearce, N., Robertson, C. F., Ruggles, R., Shah, J. R., Stewart, A. W., Strachan, D. P., Weiland, S. K., Williams, H. C.   +27 more
core   +1 more source

Beyond eosinophils: A proteomic dissection of remodeling and inflammation in suspected eosinophilic esophagitis

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Eosinophilic esophagitis (EoE) is characterized by eosinophilic inflammation and epithelial remodeling. However, current biomarkers focus predominantly on eosinophilia, overlooking basal cell hyperplasia (BCH), a histologic feature that may persist despite treatment.
Adi Eindor‐Abarbanel, Nimrod Moss‐ Ophir, Netanel Agajany, Daniel L. Cohen, Vered Richter, Haim Shirin, Efrat Broide, Tzippora Shalem   +7 more
wiley   +1 more source

Effect of cow's milk protein allergy during infancy on eating behavior at 4 years of age: A cohort study

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives This study aimed to investigate the eating behaviors of preschool children who had been exposed to a restricted diet due to an oral food challenge‐confirmed diagnosis of cow's milk protein allergy (CMPA) during early infancy. Methods This prospective cohort study compared the eating behaviors of Brazilian children previously ...
Anne Jardim‐Botelho, Marcela Barros Barbosa de Oliveira, Jackeline Motta‐Franco, Tatiane Graça Martins, Sarah Cristina Fontes Vieira, Ikaro Daniel de Carvalho Barreto, Aline Vieira Bezerra, Ricardo Queiroz Gurgel   +7 more
wiley   +1 more source