Results 61 to 70 of about 59,745 (273)

Refractory Eczema as a Presenting Feature of Common Variable Immunodeficiency

JEADV Clinical Practice, EarlyView.
ABSTRACT Common variable immunodeficiency (CVID) is the most prevalent symptomatic inborn error of immunity (IEI) in adults. It presents with recurrent infections and non‐infectious complications, including autoimmunity, lymphoproliferation and dermatitis.
Mercedes Sanchez‐Diaz, Lars Matthies, Andrea Vanegas Ramirez   +2 more
wiley   +1 more source

A Pancancer Analysis of the Oncogenic Role of S100 Calcium Binding Protein A7 (S100A7) in Human Tumors

Biology, 2022
Background: Although emerging studies support the relationship between S100 calcium binding protein A7 (S100A7) and various cancers, no pancancer analysis of S100A7 is available thus far.
Ge Peng, Saya Tsukamoto, Ko Okumura, Hideoki Ogawa, Shigaku Ikeda, François Niyonsaba   +5 more
doaj   +1 more source

Acid ceramidase overactivity drives ceramide loss, leading to atopic dry skin and Th2‐skewed immune polarization

The Journal of Pathology, EarlyView.
Abstract Ceramide deficiency in the stratum corneum (SC) is a key etiological factor in atopic dermatitis (AD). To clarify the direct role of SC ceramide depletion in impairing SC barrier and water‐holding functions and in initiating AD‐like skin symptoms and disease‐specific molecular alterations, we generated Tg mice overexpressing a mutant form of ...
Mariko Takada, Miho Sashikawa‐Kimura, Yusuke Ohno, Md Razib Hossain, Xiaonan Xie, Kazuhisa Iwabuchi, Mayumi Komine, Mamitaro Ohtsuki, Genji Imokawa   +8 more
wiley   +1 more source

Inverse association between atopy and melanoma: A case-control study [PDF]

, 2017
Heightened cutaneous immune surveillance in atopic patients may inhibit development of melanoma. The aim of this study was to analyse the association between atopy and melanoma (development and outcome).
Fieuws, S. (Steffen), Garmyn, M. (Marjan), Lambert, J., Marasigan, V. (Vivien), Medaer, K. (Karen), Morren, M.-A. (Marie-Anne), Nijsten, T.E.C. (Tamar)   +6 more
core   +7 more sources

Antigen Protease Activity on Intact or Tape-Stripped Skin Induces Acute Itch and T Helper Sensitization Leading to Airway Eosinophilia in Mice

JID Innovations
Respiratory allergen sources such as house dust mites frequently contain proteases. In this study, we demonstrated that the epicutaneous application of a model protease antigen, papain, onto intact or tape-stripped ear skin of mice induced acute ...
Toru Kimitsu, Seiji Kamijo, Tomoko Yoshimura, Yurie Masutani, Saya Shimizu, Keiko Takada, Punyada Suchiva, Hideoki Ogawa, Ko Okumura, Shigaku Ikeda, Toshiro Takai   +10 more
doaj   +1 more source

Exhaled Nitric Oxide is Not a Biomarker for Pulmonary Tuberculosis. [PDF]

, 2018
To reduce transmission of tuberculosis (TB) in resource-limited countries where TB remains a major cause of mortality, novel diagnostic tools are urgently needed.
Aston, Barnes, Chan, Daniel Pastorius, Daniel Smith, Dweik, Eduardo Ticona, Elmasri, Idh, Jon S. Friedland, José W. López, Karina M. Romero, Kim, Lim, Luz Caviedes, Maria-Cristina I. Loader, Marjory Bravard, Moore, Olin, O’Garra, Ralph, Ralph, Robert H. Gilman, Schon, Taryn Clark, Van Beek, Wang, William Checkley, Yhi   +28 more
core   +1 more source

Evidence‐based guideline for clinical practice in the diagnosis, treatment, management, and prevention of recurrent wheezing in infants and toddlers in China

Pediatric Investigation, EarlyView.
ABSTRACT Wheezing is a common respiratory symptom in infants and toddlers, and recurrent wheezing is a significant respiratory disorder affecting this age group. Given the multifactorial etiology of recurrent wheezing, clinical practice lacks standardized diagnostic and therapeutic protocols. Recent years have witnessed substantial progress in clinical
Committee of Pediatrics, China Medical Education Association, Cooperative Group of Asthma, the Subspecialty Group of Respiratory, the Society of Pediatrics, Chinese Medical Association, Pediatric Respiratory Work Committee, Society of Pulmonologists, Chinese Medical Doctor Association, Committee of Pediatrics, Chinese Research Hospital Association, Pediatric Professional Committee of the Chinese Non‐public Medical Institutions Association, Professional Committee of Children's Health and Pharmaceutical Research, China Association of Traditional Chinese Medicine, Children's Safe Medication Branch of China News of Drug Information Association, Pediatric Expert Committee of China Primary Health Care Foundation, China International Medical Foundation   +16 more
wiley   +1 more source

Withdrawal from treatment as an outcome in the Isolde study of COPD [PDF]

, 2003
Objectives: To investigate the determinants of patient withdrawal from our study, and the effect of these withdrawals on the outcome of treatment with inhaled corticosteroids in patients with COPD.
American Thoracic Society, Brazier, Burge, Chervinsky, Davies, Greening, Jarad, Jones, Jones, Jones, Jones, Lisa Willits, Meecham-Jones, Nelson, Niewoehner, Osman, P. Sherwood Burge, Paul W. Jones, Pauwels, Pauwels, Pauwels, Peter M.A. Calverley, Sally Spencer, Seemungal, Spencer, The Lung Health Study Research Group, Vestbo, Ware   +27 more
core   +1 more source

Recent advances of non‐invasive sensors for smart wearable respiratory monitoring

VIEW, EarlyView.
Respiration contains rich physiological and pathological information, making it one of the most fundamental and continuous vital signs. Respiration monitoring is a non‐invasive and simple, but incredibly powerful, tool for assessing health, managing disease, and tracking fitness.
Jianhui Chen, Baoxiang Yang, Chang Peng, Bao Yang, Licheng Zhou, Zhenyu Jiang, Zejia Liu, Yiping Liu, Liqun Tang   +8 more
wiley   +1 more source

Alteration of Immune Responses by N-acetylglucosaminyltransferase V during Allergic Airway Inflammation

Allergology International, 2011
Background: p-1,6-N-acetylglucosaminyltransferase V (Mgat5 or GlcNac-TV), which is involved in the glyco- sylation of proteins, is known to be important for down-regulation of TCR-mediated T-cell activation and negatively regulates induction of contact ...
Akiko Shibui, Aya Nambu, Eri Shimura, Sachiko Yamaguchi, Chiharu Shiraishi, Yoshitaka Sato, Ko Okumura, Sumio Sugano, Nobumichi Hozumi, Susumu Nakae   +9 more
doaj   +1 more source