Results 131 to 140 of about 53,142 (237)

Mechanisms and Predisposing Conditions for Statin‐Induced New‐Onset Type 2 Diabetes Mellitus: A Paradox Relative to Their Pleiotropic Metabolic Effects

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.
The primary function of statins is to inhibit cholesterol synthesis, which contributes to their antidiabetic effects. However, the majority of the diabetic effects of statins are due to inhibition of isoprenoid synthesis. Atorvastatin, simvastatin and rosuvastatin possess the most pronounced diabetogenic properties. In contrast, lovastatin, fluvastatin,
Ali Nosrati Andevari, Mohsen Koolivand
wiley   +1 more source

Correlation of atorvastatin with subjective memory deficits: a study from the NHANES and FAERS databases

Frontiers in Neurology
BackgroundPost-marketing regulatory data suggest a potential association between atorvastatin use and memory protection; however, findings from observational studies have been inconsistent and remain a subject of controversy.ObjectiveThis study aims to ...
Hao Zhang, Hua Huang, Panli Zhao
doaj   +1 more source

Atorvastatin in stroke: a review of SPARCL and subgroup analysis

, 2010
Branko N Huisa, Andrew B Stemer, Justin A ZivinDepartment of Neuroscience University of California, San Diego, CA, USAAbstract: Statin therapy in patients with cardiovascular disease is associated with reduced incidence of stroke.
Justin A Zivin, Branko N Huisa, Andrew B Stemer   +2 more
core  

Cardiovascular Diseases: Exploring Epidemiology, Pathophysiology, Risk Factors, and Medicinal Plant‐Based Therapies: A Narrative Review

Health Science Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background and Aims Cardiovascular diseases (CVDs) remain the leading cause of global morbidity and mortality, encompassing coronary artery disease, hypertension, heart failure, and cerebrovascular disorders. The global burden of CVD continues to rise, driven by complex interactions among endothelial dysfunction, oxidative stress, inflammation,
Nawfal Hasan Siam, Umme Halima Mithila, Sadia Alam Tisha, Hridoy Saha, Ayesha Binte Mahbub, Farhan Nizam, Johirul Islam, Noushin Tabasumma, Md. Mazharul Islam Chowdhury   +8 more
wiley   +1 more source

Direct adipotropic actions of atorvastatin: differentiation state-dependent induction of apoptosis, modulation of endocrine function, and inhibition of glucose uptake

, 2007
Statins exert anti-inflammatory, anti-atherogenic actions. The mechanisms responsible for these effects remain only partially elucidated. Diabetes and obesity are characterized by low-grade inflammation.
Mäuser, Wanda, Perwitz, Nina, Meier, Britta, Fasshauer, Mathias, Klein, Johannes   +4 more
core   +1 more source

Metabolism in Tumor: Mechanisms and Therapeutic Perspectives

MedComm, Volume 7, Issue 9, September 2026.
Tumor metabolic reprogramming converges on three hubs—the SREBP1/2–FASN–SCD1 lipogenic axis, the HIF‐1α–GLUT1–LDHA glycolytic axis, and the LDLR–SCARB1–LXR cholesterol system—which integrate transcriptional, epigenetic (histone lactylation, m6A), and microenvironmental inputs to generate metabolic plasticity, immune evasion, and therapy resistance ...
Jia‐Chen Cheng, Yi‐Xuan Hu, Xiang‐Chun Huang, Shan Jiang, Jie‐Lin Wang, Yang Zhao, Shuo Chen   +6 more
wiley   +1 more source

Evaluation of changes in the global longitudinal strain for left ventricular function before and after eight weeks of taking high dose of atorvastatin in patients with coronary slow flow phenomenon

BMC Cardiovascular Disorders
Background Coronary Slow Flow Phenomenon (CSFP) is a well-recognized clinical entity characterized by delayed opacification of coronary arteries in the presence of a normal coronary angiogram.
Nakisa Khansari, Amir Mohammad Salehi, Niloofar Mohammadi, Amir Hossein Yazdi, Zahra Sanaei   +4 more
doaj   +1 more source

Efficacy and safety of atorvastatin in South Asian patients with dyslipidemia: an open label noncomparative pilot study

, 2005
Jeetesh V Patel1, Sandeep Gupta2, Frank Lie3, Elizabeth A Hughes11Sandwell and West Birmingham Hospitals NHS Trust, West Bromwich, UK; 2Whipps Cross and St Bartholomew’s Hospitals; and 3Whipps Cross University Hospital, London, UKBackground: Rates ...
Jeetesh V Patel, Sandeep Gupta, Elizabeth A Hughes, Frank Lie   +3 more
core  

Sensitivity analysis atorvastatin vs placebo.

Atorvastatin is widely recommended for long-term secondary prevention in STEMI patients with no contraindication. Although high-dose atorvastatin has been shown to reduce important patient outcomes such as MACE, there is still doubt that high-dose ...
Rene Rodríguez-Gutiérrez (17720167), Mariano García-Campa (17720149), Edgar Francisco Carrizales-Sepúlveda (17720158), Neri Álvarez-Villalobos (8441775), Raúl Reyes-Araiza (17720164), José Ramón Azpiri-López (17720170), Ramiro Flores-Ramírez (17720152), Diego Regalado-Ceballos (17720161), Sabrina Rojo-Garza (17720155)   +8 more
core   +1 more source

Oxysterols in Cancer: From Biosynthesis and Pathophysiology to Targeted Therapeutics

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Mechanisms by which oxysterol targeting may enhance immunotherapy efficacy. This figure illustrates potential metabolic interventions that may improve antitumor immunity by modulating oxysterol related pathways. CH25H modulation may reduce 25‐HC accumulation, promote the conversion of cold tumors into hot tumors, and increase T cell infiltration and PD‐
Haili Shang, Yongsheng Li
wiley   +1 more source