Results 21 to 30 of about 16,939 (115)

Combined Beneficial Effect of Genistein and Atorvastatin on Adipogenesis in 3T3-L1 Adipocytes

open access: yesBiomolecules, 2021
Genistein (4,5,7-trihydroxyisoflavone) is abundant in various dietary vegetables, especially soybeans, and is known to have not only an estrogenic effect but also an antiadipogenic effect.
Dahae Lee   +4 more
doaj   +1 more source

Sphingosine Kinase 1 Plays an Important Role in Atorvastatin-Mediated Anti-Inflammatory Effect against Acute Lung Injury

open access: yesMediators of Inflammation, 2021
Atorvastatin is a 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) inhibitor and inhibits cholesterol synthesis. Recently, atorvastatin also showed anti-inflammatory effect in acute lung injury, ameliorating pulmonary gas-blood ...
Lan Wu   +4 more
doaj   +1 more source

Atorvastatin-loaded peptide amphiphiles against corneal neovascularization - supplementary material

open access: yes, 2023
Background: Corneal neovascularization is a sight-threatening disease. It can be treated using antiangiogenic and anti-inflammatory compounds. Therefore, atorvastatin (ATV) constitutes a suitable candidate to be administered topically. To attain suitable
Elena Sanchez-Lopez (16870506)   +2 more
core   +1 more source

Add-on effect of probucol in atherosclerotic, cholesterol-fed rabbits treated with atorvastatin. [PDF]

open access: yesPLoS ONE, 2014
OBJECTIVE: Lowering the blood concentration of low-density lipoprotein (LDL) cholesterol is the primary strategy employed in treating atherosclerotic disorders; however, most commonly prescribed statins prevent cardiovascular events in just 30% to 40% of
Yuka Keyamura   +9 more
doaj   +1 more source

Thermodynamic and Thermomicroscopy Study of Atorvastatin Calcium-Succinic Acid Binary Mixtures

open access: yesIndonesian Journal of Chemistry, 2017
Binary mixtures of pharmaceuticals significantly affect the physical and chemical properties of each component. The aim of this work was to explore the thermal behavior and solid state transformation of binary mixture of atorvastatin calcium and succinic
Yudi Wicaksono   +3 more
doaj   +1 more source

Pharmacokinetic Interaction between Atorvastatin and Omega-3 Fatty Acid in Healthy Volunteers

open access: yesPharmaceuticals, 2022
The interaction between statins and omega-3 fatty acids remains controversial. The aim of this phase 1 trial was to evaluate the pharmacokinetics of drug-drug interaction between atorvastatin and omega-3 fatty acids.
Jae Hoon Kim   +10 more
doaj   +1 more source

Effect of atorvastatin therapy on oxidant-antioxidant status and atherosclerotic plaque formation [PDF]

open access: yes, 2011
Ebru Demirel Sezer1, Eser Yildirim Sozmen1, Deniz Nart2, Taner Onat11Medical Biochemistry, 2Pathology Department, Ege University School of Medicine, Izmir, TurkeyBackground: The aim of this study was to determine the oxidant–antioxidant status and ...
Nart   +11 more
core   +1 more source

Physiologically‐Based Pharmacokinetic Modeling of Atorvastatin Incorporating Delayed Gastric Emptying and Acid‐to‐Lactone Conversion

open access: yesCPT: Pharmacometrics & Systems Pharmacology, 2019
The drug–drug interaction profile of atorvastatin confirms that disposition is determined by cytochrome P450 (CYP) 3A4 and organic anion transporting polypeptides (OATPs).
Bridget L. Morse   +9 more
doaj   +1 more source

Switching Therapy to the Second Brand of Generic Atorvastatin: A 6-Month Retrospective Cohort, Real-World Study

open access: yesDrugs - Real World Outcomes
Introduction High levels of low-density lipoprotein-cholesterol (LDL) is a major risk factor for cardiovascular diseases. While treatment with atorvastatin is beneficial, the original atorvastatin may be cost prohibitive to some patients.
Panisa Manasirisuk   +4 more
doaj   +1 more source

Plant sterol or stanol esters retard lesion formation in LDL receptor-deficient mice independent of changes in serum plant sterols

open access: yesJournal of Lipid Research, 2006
Statins do not always decrease coronary heart disease mortality, which was speculated based on increased serum plant sterols observed during statin treatment.
Jogchum Plat   +4 more
doaj   +1 more source

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