Potential application of network descriptions for understanding conformational changes and protonation states of ABC transporters [PDF]
Current Pharmaceutical Design, 2013, 19, 4155-4172, 2012 The ABC (ATP Binding Cassette) transporter protein superfamily comprises a large number of ubiquitous and functionally versatile proteins conserved from archaea to humans. ABC transporters have a key role in many human diseases and also in the development of multidrug resistance in cancer and in parasites. Although a dramatic progress has been achieved
arxiv +1 more source
Mutations in the Arabidopsis Peroxisomal ABC Transporter COMATOSE Allow Differentiation between Multiple Functions In Planta: Insights from an Allelic Series [PDF]
, 2008 COMATOSE (CTS), the Arabidopsis homologue of human Adrenoleukodystrophy protein (ALDP), is required for import of substrates for peroxisomal β-oxidation.
Baker, A. +7 more
core +4 more sources
Towards identification of the substrates of ATP-binding cassette transporters [PDF]
Plant Physiology, 2018 Most ATP-binding cassette (ABC) proteins function in transmembrane transport, and plant genomes encode a large number of ABC transporters compared with animal or fungal genomes. These transporters have been classified into eight subfamilies according to their topology and phylogenetic relationships.
Lefèvre, François, Boutry, Marc
openaire +4 more sources
Coupled ATPase-adenylate kinase activity in ABC transporters
Nature Communications, 2016 ATP-binding cassette (ABC) transporters hydrolyse ATP to transport molecules across the cell membrane. Here Vogelet al. show that the ABC exporter MsBA can couple ATP hydrolyse to an adenylate kinase activity that seems to be predominant at low ATP ...
Hundeep Kaur +5 more
doaj +1 more source
Genome-wide analysis of ATP binding cassette (ABC) transporters in tomato.
PLoS ONE, 2018 ATP binding cassette (ABC) transporters are proteins that actively mediate the transport of a wide range of molecules, such as organic acids, metal ions, phytohormones and secondary metabolites.
Peter Amoako Ofori +9 more
doaj +1 more source
Cryo-EM structure of ABCG5/G8 in complex with modulating antibodies
Communications Biology, 2021 Zhang et al. present the cryo-EM structure of ATP-binding cassette transporters ABCG5/G8 in complex with the Fab fragments from two monoclonal antibodies at 3.3 Å resolution.
Hanzhi Zhang +8 more
doaj +1 more source
Effect of oxidative stress on ABC transporters: contribution to epilepsy pharmacoresistance [PDF]
, 2017 Epilepsy is a neurological disorder affecting around 1%-2% of population worldwide and its treatment includes use of antiepileptic drugs to control seizures. Failure to respond to antiepileptic drug therapy is a major clinical problem and over expression
Grewal, G. K. +5 more
core +2 more sources
Inferring interaction partners from protein sequences [PDF]
Proc. Natl. Acad. Sci. U.S.A., 113(43): 12180-12185 (2016), 2016 Specific protein-protein interactions are crucial in the cell, both to ensure the formation and stability of multi-protein complexes, and to enable signal transduction in various pathways. Functional interactions between proteins result in coevolution between the interaction partners, causing their sequences to be correlated.
arxiv +1 more source
Proton Motive Force-Dependent Hoechst 33342 Transport by the ABC Transporter LmrA of Lactococcus lactis [PDF]
, 2005 The fluorescent compound Hoechst 33342 is a substrate for many multidrug resistance (MDR) transporters and is widely used to characterize their transport activity.
Abbreviations ABC +35 more
core +2 more sources
ATP-Binding Cassette Cholesterol Transporters and Cardiovascular Disease [PDF]
Circulation Research, 2006 A hallmark of atherosclerotic cardiovascular disease (CVD) is the accumulation of cholesterol in arterial macrophages. Factors that modulate circulating and tissue cholesterol levels have major impacts on initiation, progression, and regression of CVD.
John F. Oram, Andrew T. M. Vaughan
openaire +3 more sources