Results 31 to 40 of about 50,926 (288)

A single high-dose irradiation changes accumulation of methotrexate and gene expression levels of SLC and ABC transporters in cancer cells

Frontiers in Pharmacology, 2023
Chemoradiotherapy is frequently used to treat cancer. Stereotactic body radiotherapy (SBRT) is a single high-dose radiotherapy used to treat a variety of cancers.
Kakeru Sato, Tatsuya Seki, Asuka Mizutani, Yuka Muranaka, Shiho Hirota, Kodai Nishi, Kana Yamazaki, Ryuichi Nishii, Takeo Nakanishi, Ikumi Tamai, Keiichi Kawai, Keiichi Kawai, Masato Kobayashi   +12 more
doaj   +1 more source

De novo macrocyclic peptides dissect energy coupling of a heterodimeric ABC transporter by multimode allosteric inhibition

eLife, 2021
ATP-binding cassette (ABC) transporters constitute the largest family of primary active transporters involved in a multitude of physiological processes and human diseases.
Erich Stefan, Richard Obexer, Susanne Hofmann, Khanh Vu Huu, Yichao Huang, Nina Morgner, Hiroaki Suga, Robert Tampé   +7 more
doaj   +1 more source

Hsa_Circ_0007841 Enhances Multiple Myeloma Chemotherapy Resistance Through Upregulating ABCG2

Technology in Cancer Research & Treatment, 2020
The current researches have reported that circular RNA is an important regulatory factor in the progression of various human disease. However, the function and mechanism of most circular RNAs remain unknown in cancers including multiple myeloma.
Yan Song MD, Ning Hu MD, Xiaowei Song MD, Juhong Yang MD   +3 more
doaj   +1 more source

The Mechanisms of Yu Ping Feng San in Tracking the Cisplatin-Resistance by Regulating ATP-Binding Cassette Transporter and Glutathione S-Transferase in Lung Cancer Cells

Frontiers in Pharmacology, 2021
Cisplatin is one of the first line anti-cancer drugs prescribed for treatment of solid tumors; however, the chemotherapeutic drug resistance is still a major obstacle of cisplatin in treating cancers. Yu Ping Feng San (YPFS), a well-known ancient Chinese
Yingqing Du, Yuzhong Zheng, Ciel Xiaomei Yu, Lishan Zhong, Yafang Li, Baomeng Wu, Weihui Hu, Elsa Wanyi Zhu, Venus Wei Xie, Qitian Xu, Xingri Zhan, Yamiao Huang, Liyi Zeng, Zhenxia Zhang, Xi Liu, Jiachuan Yin, Guangcai Zha, Kelvin Chan, Kelvin Chan, Karl Wah Keung Tsim   +19 more
doaj   +1 more source

Thermodynamics of the ATPase Cycle of GlcV, the Nucleotide-Binding Domain of the Glucose ABC Transporter of Sulfolobus solfataricus [PDF]

, 2006
ATP-binding cassette transporters drive the transport of substrates across the membrane by the hydrolysis of ATP. They typically have a conserved domain structure with two membrane-spanning domains that form the transport channel and two cytosolic ...
Schuurman-Wolters, Gea,, Pretz, Monika G., Tampé, Robert,, van der Does, Chris, Driessen, Arnold J. M., Albers, Sonja-Verena,, Tampe, Robert, Does, Chris van der,, Albers, Sonja-Verena, Schuurman-Wolters, Gea; id_orcid, Pretz, Monika G.,, Albers, Sonja Verena, Does, Chris van der, Schuurman-Wolters, Gea, Driessen, Arnold J.M.,   +14 more
core   +1 more source

ATP Binding Cassette transporters associated with chemoresistance: transcriptional profiling in extreme cohorts and their prognostic impact in a cohort of 281 acute myeloid leukemia patients

Haematologica, 2011
Background A major issue in the treatment of acute myeloid leukemia is resistance to chemotherapeutic drugs. An increasing number of ATP-Binding-Cassette transporters have been demonstrated to cause resistance to cancer drugs.
Christophe Marzac, Edith Garrido, Ruoping Tang, Fanny Fava, Pierre Hirsch, Cinzia De Benedictis, Elise Corre, Simona Lapusan, Jean-Yves Lallemand, Jean-Pierre Marie, Eric Jacquet, Ollivier Legrand   +11 more
doaj   +1 more source

Nucleotide-Binding Sites of the Heterodimeric LmrCD ABC-Multidrug Transporter of Lactococcus lactis Are Asymmetric [PDF]

, 2006
LmrCD is a lactococcal, heterodimeric multidrug transporter, which belongs to the ABC superfamily. It consists of two half-transporters, LmrC and LmrD, that are necessary and sufficient for drug extrusion and ATP hydrolysis.
Konings, Wil N., Lubelski, Jacek, Konings, Wil N.,, Merkerk, Ronald van, Lubelski, Jacek,, Merkerk, Ronald van,, Driessen, Arnold J.M.,, Driessen, Arnold J.M.   +7 more
core   +1 more source

Cardiac PET Imaging of ATP Binding Cassette (ABC) Transporters: Opportunities and Challenges

Pharmaceuticals, 2023
Adenosine triphosphate binding cassette (ABC) transporters are a broad family of membrane protein complexes that use energy to transport molecules across cells and/or intracellular organelle lipid membranes. Many drugs used to treat cardiac diseases have
Wanling Liu, Pascalle Mossel, Verena Schwach, Riemer H. J. A. Slart, Gert Luurtsema   +4 more
doaj   +1 more source

Role of ABCG1 and other ABCG family members in lipid metabolism

Journal of Lipid Research, 2001
The molecular cloning and identification of mutations in ATP-binding cassette transporters in hereditary diseases have greatly expanded our knowledge of the normal physiology of intracellular lipid transport processes.
Gerd Schmitz, Thomas Langmann, Susanne Heimerl   +2 more
doaj   +1 more source

A single power stroke by ATP binding drives substrate translocation in a heterodimeric ABC transporter

eLife, 2020
ATP-binding cassette (ABC) transporters constitute the largest family of primary active transporters, responsible for many physiological processes and human maladies.
Erich Stefan, Susanne Hofmann, Robert Tampé   +2 more
doaj   +1 more source