Results 31 to 40 of about 46,561 (242)
Biological Functions and Clinical Significance of the ABCG1 Transporter
BiologyATP-binding cassette (ABC) transporters are a large family of proteins that transport various substances across cell membranes using energy from ATP hydrolysis.
Stanislav Kotlyarov, Anna Kotlyarova
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Microorganisms, 2021 ATP-binding cassette (ABC) transporters are usually involved in the translocation of their cognate substrates, which is driven by ATP hydrolysis. Typically, these transporters are required for the import or export of a wide range of substrates such as ...
Jeanine Rismondo, Lisa Maria Schulz
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The Human ATP-Binding Cassette (ABC) Transporter Superfamily [PDF]
Genome Research, 2001 The ATP-binding cassette (ABC) transporter superfamily comprises membrane proteins that efflux various substrates across extra- and intra-cellular membranes. Mutations in ABC genes cause 21 human disorders or phenotypes with Mendelian inheritance, including cystic fibrosis, adrenoleukodystrophy, retinal degeneration, cholesterol, and
Michael Dean +2 more
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eLife, 2014 Multidrug ATP binding cassette (ABC) exporters are ubiquitous ABC transporters that extrude cytotoxic molecules across cell membranes. Despite recent progress in structure determination of these transporters, the conformational motion that transduces the
Smriti Mishra +5 more
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FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
D-helix influences dimerization of the ATP-binding cassette (ABC) transporter associated with antigen processing 1 (TAP1) nucleotide-binding domain. [PDF]
PLoS ONE, 2017 ATP-binding cassette (ABC) transporters form a large family of transmembrane importers and exporters. Using two nucleotide-binding domains (NBDs), which form a canonical ATP-sandwich dimer at some point within the transport cycle, the transporters ...
Ahmet S Vakkasoglu +2 more
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Frontiers in Marine Science, 2022 Cold surges result in a rapid drop in air temperature and freezing of seawater, which was likely to impact bacterial communities. We examined the differences in bacteria abundance and bacterial community composition in the sea ice and seawater during a ...
Hongwei Ren +7 more
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ATP-binding cassette transporters in Escherichia coli
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2008 ATP-binding cassette (ABC) transporters are integral membrane proteins that actively transport molecules across cell membranes. In Escherichia coli they consist primarily of import systems that involve in addition to the ABC transporter itself a substrate binding protein and outer membrane receptors or porins, and a number of transporters with varied ...
Moussatova, Anastassiia +3 more
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A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline
FEBS Open Bio, EarlyView.Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey +4 more
wiley +1 more source
Role of lipid transporters in fungal physiology and pathogenicity
Computational and Structural Biotechnology Journal, 2019 The fungal cell wall and membrane are the most common targets of antifungal agents, but the potential of membrane lipid organization in regulating drug-target interactions has yet to be investigated. Energy-dependent lipid transporters have been recently
Juliana Rizzo +5 more
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