The impact of ATP-binding cassette transporters on metabolic diseases [PDF]
Nutrition & Metabolism, 2020 Currently, many people worldwide suffer from metabolic diseases caused by heredity and external factors, such as diet. One of the symptoms of metabolic diseases is abnormal lipid metabolism.
Zixiang Ye, Yifei Lu, Tao Wu
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ECF-Type ATP-Binding Cassette Transporters [PDF]
Annual Review of Biochemistry, 2019 Energy-coupling factor (ECF)–type ATP-binding cassette (ABC) transporters catalyze membrane transport of micronutrients in prokaryotes. Crystal structures and biochemical characterization have revealed that ECF transporters are mechanistically distinct from other ABC transport systems.
S Rempel, Dirk J Slotboom
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ATP-binding cassette transporters mediate differential biosynthesis of glycosphingolipid species [PDF]
Journal of Lipid Research, 2021 The cytosolic-oriented glucosylceramide (GlcCer) synthase is enigmatic, requiring nascent GlcCer translocation to the luminal Golgi membrane to access glycosphingolipid (GSL) anabolic glycosyltransferases. The mechanism by which GlcCer is flipped remains
Monique Budani +2 more
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Predicting ATP-Binding Cassette Transporters Using the Random Forest Method [PDF]
Frontiers in Genetics, 2020 ATP-binding cassette (ABC) proteins play important roles in a wide variety of species. These proteins are involved in absorbing nutrients, exporting toxic substances, and regulating potassium channels, and they contribute to drug resistance in cancer ...
Ruiyan Hou +3 more
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Cadmium transport by mammalian ATP-binding cassette transporters. [PDF]
BiometalsAbstractCellular responses to toxic metals depend on metal accessibility to intracellular targets, reaching interaction sites, and the intracellular metal concentration, which is mainly determined by uptake pathways, binding/sequestration and efflux pathways.
Thévenod F, Lee WK.
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DeepRTCP: Predicting ATP-Binding Cassette Transporters Based on 1-Dimensional Convolutional Network [PDF]
Frontiers in Cell and Developmental Biology, 2021 ATP-binding cassette (ABC) transporters can promote cells to absorb nutrients and excrete harmful substances. It plays a vital role in the transmembrane transport of macromolecules.
Zhaoxi Zhang +3 more
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ATP-Binding Cassette Transporters in the Clinical Implementation of Pharmacogenetics [PDF]
Journal of Personalized Medicine, 2018 ATP-binding cassette (ABC) transporters are involved in a large number of processes and contribute to various human genetic diseases. Among other functions, ABC proteins are involved in the transport of multiple drugs through cells.
Luis A López-Fernández
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Peptides and ATP binding cassette peptide transporters [PDF]
Research in Microbiology, 2001 In this review our knowledge of ATP binding cassette (ABC) transporters specific for peptides is discussed. Besides serving a role in nutrition of the cell, the systems participate in various signaling processes that allow (micro)organisms to monitor the local environment. In bacteria, these include regulation of gene expression, competence development,
Detmers, F.J.M. +2 more
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Identification and Characterization of ATP-Binding Cassette Transporters in Chlamydomonas reinhardtii [PDF]
Marine Drugs, 2022 Microalgae are promising microorganisms used to produce value-added products or to develop sustainable approaches for environmental remediation.
Xiangyu Li +5 more
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Expression of some ATP-binding cassette transporters in acute myeloid leukemia [PDF]
Hematology Reports, 2017 Hematopoietic cells express ATP binding cassette (ABC) transporters in relation to different degrees of differentiation. One of the known multidrug resistance mechanisms in acute myeloid leukemia (AML) is the overexpression of efflux pumps belonging to ...
Antonella Maria Salvia +8 more
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