Results 81 to 90 of about 156,745 (364)

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

FEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli, Andrea Spinaci, Cui Chang, Rosaria Volpini, Catia Lambertucci, Matteo Landriscina, Vincenza Conteduca, Consuelo Amantini, Cristina Aguzzi, Laura Zeppa, Martina Giangrossi, Laura Soverchia, Matteo Santoni, Massimo Nabissi, Giorgio Santoni, Carlo Polidori   +15 more
wiley   +1 more source

Efflux in fungi: la pièce de résistance. [PDF]

PLoS Pathogens, 2009
Pathogens must be able to overcome both host defenses and antimicrobial treatment in order to successfully infect and maintain colonization of the host. One way fungi accomplish this feat and overcome intercellular toxin accumulation is efflux pumps, in ...
Jeffrey J Coleman, Eleftherios Mylonakis
doaj   +1 more source

RESPONSE OF MDR1 AND PDR1 ATP-BINDING CASSETTE-TYPE TRANSPORTER GENES TO BIOTIC SIGNALS IN WHEAT FLAG LEAF TIPS [PDF]

Journal of Plant Development, 2020
ATP-binding cassette-type (ABC) transporters are highly implicated in detoxification processes but not restricted to detoxification processes. Several ABC transporters including wheat Lr34 were shown to function in plant defense responses and secretion ...
Kipkios TUBEI, Lucas CHURCH, Tim XING
doaj   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Role of ATP binding and hydrolysis in the gating of the cystic fibrosis transmembrane conductance regulator

Annals of Thoracic Medicine, 2012
The CFTR gene is unique within the ATP-binding cassette (ABC) protein family, predominantly of transporters, by coding a chloride channel. The gating mechanism of ABC proteins has been characterized by the ATP Switch model in terms cycles of dimer ...
Taras Gout
doaj   +1 more source

Calculating complexity of large randomized libraries [PDF]

Journal of Theoretical Biology 259 (3), 641-645, 2009, 2014
Randomized libraries are increasingly popular in protein engineering and other biomedical research fields. Statistics of the libraries are useful to guide and evaluate randomized library construction. Previous works only give the mean of the number of unique sequences in the library, and they can only handle equal molar ratio of the four nucleotides at
arxiv   +1 more source

The Allosteric Regulatory Mechanism of the Escherichia coli MetNI Methionine ATP Binding Cassette (ABC) Transporter [PDF]

, 2015
The MetNI methionine importer of Escherichia coli, an ATP Binding Cassette (ABC) transporter, uses the energy of ATP binding and hydrolysis to catalyze the high affinity uptake of D- and L-methionine.
Rees, Douglas C., Yang, Janet G.
core   +2 more sources

RhoA and Rac1 as Mechanotransduction Mediators in Colorectal Cancer

Advanced Biology, EarlyView.
Analysing RhoA and Rac1 protein levels in Colorectal cancer (CRC) samples under mechanical strain highlights their potential as diagnostic markers. Monitoring their activity could offer valuable insights into how cancer spreads, paving the way for new approaches to better understand and diagnose colorectal cancer.
Sharda Yadav, Sanjaya KC, Mark A. T. Blaskovich, Cu‐tai Lu, Alfred K Lam, Nam‐Trung Nguyen   +5 more
wiley   +1 more source

ABC transporters as multidrug resistance mechanisms and the development of chemosensitizers for their reversal

Cancer Cell International, 2005
One of the major problems related with anticancer chemotherapy is resistance against anticancer drugs. The ATP-binding cassette (ABC) transporters are a family of transporter proteins that are responsible for drug resistance and a low bioavailability of ...
Choi Cheol-Hee
doaj   +1 more source

Site-specific recombinatorics: in situ cellular barcoding with the Cre Lox system [PDF]

BMC Systems Biology, 10:43, 2016, 2016
Cellular barcoding is a significant, recently developed, biotechnology tool that enables the familial identification of progeny of individual cells in vivo. Most existing approaches rely on ex vivo viral transduction of cells with barcodes, followed by adoptive transfer into an animal, which works well for some systems, but precludes barcoding cells in
arxiv   +1 more source