Results 21 to 30 of about 3,294 (160)

Atp1a2 ASOs specifically target Atp1a2.

, 2023
(A) Relative levels of Atp1a1 mRNA in primary mouse astrocytes (WT), 48h after nucleofection with Atp1a2 ASO1, ASO3 or ctrl ASO. Shown here are pooled fold change values from 3 independent experiments, ns = not significant by one-way ANOVA.
Azad Bonni (221908), Kathleen M. Schoch (17468095), Anthony Verbeck (17468098), Timothy M. Miller (2480425), Hao Chen (5190), Celeste M. Karch (13110199), Abhirami K. Iyer (17468092), Grant Galasso (17468101), Sarah Smith (63540), Anna Oldenborg (17468104)   +9 more
core   +1 more source

Overexpression of α2 subunit of Na-K-ATPase suppresses invasion and migration of human breast cancer cells in vitro by inhibiting the Src/PI3K/Akt signaling pathway

Di-san junyi daxue xuebao, 2019
Objective To investigate the expression of α2 subunit of Na-K-ATPase (ATP1A2) in human breast cancer and the effects of ATP1A2 overexpression on the invasion and migration of breast cancer cells in vitro.
QIN Yi, QIN Yi, YUAN Hongfan, YUAN Hongfan, ZENG Beilei, ZENG Beilei   +5 more
doaj   +1 more source

Migraine‐Associated Mutation in the Na,K‐ATPase Leads to Disturbances in Cardiac Metabolism and Reduced Cardiac Function

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Mutations in ATP1A2 gene encoding the Na,K‐ATPase α2 isoform are associated with familial hemiplegic migraine type 2. Migraine with aura is a known risk factor for heart disease.
Christian Staehr, Palle Duun Rohde, Nikolaj Thure Krarup, Steffen Ringgaard, Christoffer Laustsen, Jacob Johnsen, Rikke Nielsen, Hans Christian Beck, Jens Preben Morth, Karin Lykke‐Hartmann, Nichlas Riise Jespersen, Denis Abramochkin, Mette Nyegaard, Hans Erik Bøtker, Christian Aalkjaer, Vladimir Matchkov   +15 more
doaj   +1 more source

Two pediatric patients with hemiplegic migraine presenting as acute encephalopathy: case reports and a literature review

Frontiers in Pediatrics, 2023
IntroductionHemiplegic migraine (HM) is a rare subtype of migraine. HM in children may be atypical in the initial stage of the disease, which could easily lead to misdiagnosis.MethodsWe report two cases of atypical hemiplegic migraine that onset as an ...
Yu Xiang, Fei Li, Zhenfeng Song, Zhi Yi, Chengqing Yang, Jiao Xue, Ying Zhang   +6 more
doaj   +1 more source

Peculiarities of Hemiplegic Migraine in Children

Вопросы современной педиатрии, 2016
The article describes the individual peculiarities of a rare disease — hemiplegic migraine — in 3 patients (two girls aged 2 and 14 years old and a boy of 16 years).
S. L. Moiseeva, C. Betzler, T. Herberholdt, G. Kluger, M. Staudt   +4 more
doaj   +1 more source

Functional correlation of ATP1A2 mutations with phenotypic spectrum: from pure hemiplegic migraine to its variant forms

The Journal of Headache and Pain, 2021
Background Mutations in ATP1A2, the gene encoding the α2 subunit of Na+/K+-ATPase, are the main cause of familial hemiplegic migraine type 2 (FHM2). The clinical presentation of FHM2 with mutations in the same gene varies from pure FHM to severe forms ...
Yingji Li, Wenjing Tang, Li Kang, Shanshan Kong, Zhao Dong, Dengfa Zhao, Ruozhuo Liu, Shengyuan Yu   +7 more
doaj   +1 more source

Heterozygous de novo mutation in the ATP1A2 gene in a patient with alternating hemiplegia of childhood

Pediatria Polska, 2023
Alternating hemiplegia of childhood (AHC) is characterized by recurrent hemiplegic episodes and paroxysmal disorders, dystonia, nystagmus, epileptic seizure, mental retardation, and intellectual impairment.
Katarzyna Wojciechowska, Agata Pikulicka, Olga Drgas, Żaneta Brudkowska, Iwona Żarnowska   +4 more
doaj   +1 more source

CNS administered Atp1a2-specific ASOs do not affect Atp1a2 expression in skeletal muscle.

, 2023
Relative Atp1a2 transcript levels in skeletal muscle (n = 5 mice/group from a subset of SOD1*G93A mice shown in Fig 4, molecular expression not significant by unpaired t-test with Welch’s correction. (TIF)
Azad Bonni (221908), Kathleen M. Schoch (17468095), Anthony Verbeck (17468098), Timothy M. Miller (2480425), Hao Chen (5190), Celeste M. Karch (13110199), Abhirami K. Iyer (17468092), Grant Galasso (17468101), Sarah Smith (63540), Anna Oldenborg (17468104)   +9 more
core   +1 more source

Decreased content of ascorbic acid (vitamin C) in the brain of knockout mouse models of Na+,K+-ATPase-related neurologic disorders.

PLoS ONE, 2021
Na+,K+-ATPase is a crucial protein responsible for maintaining the electrochemical gradients across the cell membrane. The Na+,K+-ATPase is comprised of catalytic α, β, and γ subunits.
Keiko Ikeda, Adriana A Tienda, Fiona E Harrison, Kiyoshi Kawakami   +3 more
doaj   +1 more source

De novo exonic duplication of ATP1A2 in Italian patient with hemiplegic migraine: a case report

The Journal of Headache and Pain, 2017
Background Sporadic Hemiplegic Migraine is a rare form of migraine headache. Mutations in three different genes, two ion-channel genes and one encoding an ATP exchanger, CACNA1A, ATP1A2 and SCN1A are all responsible for the FHM phenotype, thus indicating
Stella Gagliardi, Gaetano Salvatore Grieco, Francesca Gualandi, Luisa Maria Caniatti, Elisabetta Groppo, Marialuisa Valente, Giuseppe Nappi, Marcella Neri, Cristina Cereda   +8 more
doaj   +1 more source