Results 91 to 100 of about 60,219 (305)

Transport and catabolism of murein tripeptide in Escherichia coli K-12 [PDF]

, 2011
In bacteria, extracellular peptides are not only a source of nutrients but also play important roles in cell-cell communication. The primary mode of uptake of these peptides in bacteria is via ATP Binding Cassette (ABC) transporters.
Maqbool, Abbas
core  

Fine‐Tuned Regulation of mRNA Translation and Transport by STAU2 Condensate Facilitates Neuronal Development and Plasticity

Advanced Science, EarlyView.
STAU2 undergoes phase separation to form dynamic condensates that package target mRNAs and deliver them to the distal ends of growing neuronal dendrites. STAU2 condensates stabilize embedded mRNAs and repress their translation. Synaptic activity bidirectionally remodels STAU2 condensates, coordinating local translation of STAU2‐associated mRNAs ...
Shijing Huang, Yuanyuan Chu, Ruiqian Zhao, Siyu Li, Yu Feng, Hongdan Zheng, Yunli Xie, Tong Wang, Wenyu Wen   +8 more
wiley   +1 more source

Corticotropin-Releasing Hormone (CRH) Promotes Macrophage Foam Cell Formation via Reduced Expression of ATP Binding Cassette Transporter-1 (ABCA1). [PDF]

PLoS ONE, 2015
Atherosclerosis, the major pathology of cardiovascular disease, is caused by multiple factors involving psychological stress. Corticotropin-releasing hormone (CRH), which is released by neurosecretory cells in the hypothalamus, peripheral nerve terminals
Wonkyoung Cho, Jihee Lee Kang, Young Mi Park   +2 more
doaj   +1 more source

Transcriptional regulation of the ABCC6 gene and the background of impaired function of missense disease-causing mutations.

, 2013
The human ATP-binding cassette family C member 6 (ABCC6) gene encodes an ABC transporter protein expressed primarily in the liver and to a lesser extent in the kidneys and the intestines.
Boussac, Hugues de, Váradi, András, Bacquet, Caroline, Fülöp, Krisztina, Arányi, Tamás, Pomozi, Viola   +5 more
core   +1 more source

Photodynamic Priming and Minocycline Overcome Chemoresistance by Reprogramming the Pancreatic Tumor Immune Microenvironment In Vivo

Advanced Science, EarlyView.
Dual priming with minocycline and photodynamic priming reprograms the pancreatic tumor microenvironment to overcome chemoresistance. By suppressing DNA repair enzyme Tdp1, inducing photooxidative damage, and enhancing irinotecan delivery via light‐activated nanoencapsulation, this strategy remodels the tumor microenvironment and drives immune ...
Fernanda V. Cabral, Jose Quilez‐Alburquerque, Olivia Mooradian, Shivendran Vytheswarran, Badri Parshad, Girgis Obaid, Huang‐Chiao Huang, Tayyaba Hasan   +7 more
wiley   +1 more source

Intestinal Source Control of Lipid Metabolism by Enzyme‐Probiotic Encapsulated, Spatiotemporal Crosslinked, and Small Intestine‐Adhesive Hydrogel Microspheres

Advanced Science, EarlyView.
A thiol‐modified alginate hydrogel microsphere‐encapsulated enzyme‐probiotic biohybrid (AKK‐COD) system has been developed to address the spatiotemporal delivery and colonization challenges of small intestine‐targeted probiotic for lipid metabolism regulation. The system exerts sequential functions of intragastric protection, small intestinal adhesion,
Xiaolin Wu, Weiwen Liang, Siqi He, Guangyuan Chen, Hui Zhou, Xinglong Wang, Yifei Li, Dingcai Wu, Bingna Zheng, Ruoxu Dou, Rongkang Huang   +10 more
wiley   +1 more source

SERRATE Regulates Floral Meristem Activity by Antagonizing SHOOT MERISTEMLESS and Repressing Cytokinin Signaling

Advanced Science, EarlyView.
Floral meristem (FM) activity is crucial for the initiation of floral organs. In this study, SE represses IPT7 expression and cytokinin signaling via both the miR171c‐5p–KNAT2 and miR164c–CUC1/2–KNAT2 regulatory modules, thereby repressing FM activity. In contrast, STM induces both KNAT2 and IPT7 expression.
Wen Yang, Yiting Wang, Yuxin You, Zhiyue Wu, Dongbao Li, Xin Wang, Yongsheng Chang, Hang Zhao, Tao Zhu, Dijun Chen, Wei Chen, Bo Sun   +11 more
wiley   +1 more source

Characterisation of the vibrio cholerae antibiotic resistance var operon [PDF]

, 2007
The discovery and use of antibiotics in the chemotherapy of bacterial infections has revolutionised medicine as it is today. Unfortunately, the progressive use of antibiotics has promoted the evolution of bacterial defences against these mediators and ...
Massam-Wu, Teresa
core  

Direct evidence that the N-terminal extensions of the TAP complex act as autonomous interaction scaffolds for the assembly of the MHC I peptide-loading complex

, 2012
The loading of antigenic peptides onto major histocompatibility complex class I (MHC I) molecules is an essential step in the adaptive immune response against virally or malignantly transformed cells.
Abele, Rupert, Sabine Hulpke, Tampé, Robert, Ueda, Kazumitsu, Ueda, K., Kazumitsu Ueda, Tomioka, Maiko, Rupert Abele, Tomioka, M., Robert Tampé, Maiko Tomioka, Kremmer, E., Abele, R., Hulpke, S., Hulpke, Sabine, Kremmer, Elisabeth, Tampé, R., Elisabeth Kremmer   +17 more
core   +1 more source

Targeting ANGPTL3 and IL‐33/ST2 Ameliorates Diabetic Kidney Disease by Reducing Lipotoxicity, Alleviating Inflammation and Inhibiting Fibrosis

Advanced Science, EarlyView.
Dual targeting of ANGPTL3 and IL‐33/ST2 attenuates diabetic kidney disease by reprogramming lipid–inflammatory crosstalk. This strategy reduces renal lipotoxicity, suppresses inflammatory activation, and limits fibrotic remodeling, thereby preserving kidney structure and function and highlighting a mechanism‐guided therapeutic approach for metabolic ...
Zhuojin Li, Zhonglian Cao, Rongrui Zhou, Xu Cheng, Xiaozhi Hu, Shuwen Xu, Zihan Dou, Ling Du, Dianwen Ju   +8 more
wiley   +1 more source