Results 111 to 120 of about 60,219 (305)

Funktionelle Rekonstitution des menschlichen lysosomale Peptid-Transporter TAPL zeigt die Substratspezifität

, 2009
The transporter associated with antigen processing-like (TAPL) acts as a lysosomal ATP-dependent polypeptide transporter with broad length selectivity. To characterize in detail its substrate specificity, a procedure for solubilization, purification and ...
Zhao, Chenguang
core  

Decreased expression of breast cancer resistance protein in the duodenum in patients with obstructive cholestasis [PDF]

, 2006
Background/Aims: The expression of transporters involved in bile acid homeostasis is differentially regulated during obstructive cholestasis. Since the drug efflux transporter breast cancer resistance protein (BCRP) is known to transport bile acids, we ...
Beuers, Ulrich, Lehmann, Frank, Terracciano, Luigi, Hruz, Petr, Zimmermann, Christian, Gutmann, Heike, Drewe, Juergen, Beglinger, Christoph   +7 more
core   +1 more source

Inosine‐Triphosphate‐Pyrophosphatase Activity as a Potential Predictor of Methotrexate Remission in Juvenile Idiopathic Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Methotrexate (MTX) is the first‐line therapy for juvenile idiopathic arthritis (JIA), but up to 40% of patients do not respond to it. Low inosine triphosphate pyrophosphatase (ITPA) activity has been associated with reduced clinical remission. We investigated the role and underlying mechanisms of ITPA in vitro. Methods ITPA enzymatic activity
Sofia Sindici Forgiarini, Marianna Lucafò, Debora Curci, Davide Selvestrel, Valentina Moressa, Sofia Pagarin, Barbara Bellich, Martina Franzin, Alberto Tommasini, Mara L. Becker, Laura B. Ramsey, Susan D. Thompson, Carl D. Langefeld, Federica Corba, Edoardo Marrani, Gabriele Simonini, Gabriele Stocco, Giuliana Decorti, Andrea Taddio, Serena Pastore   +19 more
wiley   +1 more source

Der katalytische Zyklus der Nukleotid-bindenden Domäne des ABC-Transporters HlyB

, 2005
Nucleotide-binding domains (NBDs), roughly 27 kDa in size, are conservative components of the large family of ABC (ATP-binding cassette) transporters, which includes importers, exporters, and receptors.
Zaitseva, Jelena
core  

ABCB5 and the regulation of p16INK4a by non-coding RNA [PDF]

, 2014
p16INK4a (p16) traps the cell at the restriction point of the cell cycle by binding to cyclin-dependent kinase 4/6 thus preventing the phosphorylation of the retinoblastoma protein (pRB).
Braker, Paul
core  

Fungicide-driven evolution and molecular basis of multidrug resistance in field populations of the grey mould fungus Botrytis cinerea

, 2009
The grey mould fungus Botrytis cinerea causes losses of commercially important fruits, vegetables and ornamentals worldwide. Fungicide treatments are effective for disease control, but bear the risk of resistance development.
Pradier Jean-Marc, Pradier, J.M., Walker, Anne-Sophie, Mernke, Dennis, Pradier, Jean Marc, J. M., Leroux, Pierre, Matthias Hahn, Matthias Kretschmer, Sabine Fillinger, Walker, Anne Sophie, Kretschmer, M., Hahn, Matthias, Fillinger Sabine, Jean-Marc Pradier, Mosbach, Andreas, Walker, A.S., Mernke, Denis, Kretschmer Matthias, Mernke, D., Fillinger, S., de Waard, Maarten A, Maarten A De Waard, Walker, Anne Sophie, A. S., Leroux, P., de Waard, M.A., De Waard Maarten A., Leroux Pierre, Fillinger-David, Sabine, Helma, S. H., Anne-Sophie Walker, Pierre Leroux, Waard, Maarten A. De, Schoonbeek, Henk-jan, Leroch, Michaela, Leroch, M., Pradier, Jean Marc, Leroux, Pierre, P., Mosbach, A., Waard, M.A., de, Dennis Mernke, Pradier, Jean-Marc, Hahn Matthias, Leroch Michaela, Walker Anne-Sophie, Schoonbeek Henk-Jan, Fillinger-David, Sabine, Helma, Henk-Jan Schoonbeek, Mernke Dennis, Fillinger, Sabine, Mosbach Andreas, Andreas Mosbach, Michaela Leroch, Kretschmer, Matthias, Schoonbeek, H.J., Hahn, M.   +53 more
core   +1 more source

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Evaluation of Genome in Early Familial Coronary Artery Disease: A Case Report

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2019
Background and Objectives: Coronary artery diseases (CAD) are the most common cause of death in Iran and worldwide. Myocardial infarction (MI) is a complex multifactorial and the most severe type of CAD.
Mohammad Javad Ghorbani, Nematollah Razmi, Seyed Mohammad Bagher Tabei, Mohammad Javad Zibaeenezhad, Hamid Reza Goodarzi   +4 more
doaj  

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source