Results 131 to 140 of about 60,219 (305)

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, EarlyView.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

Living Microbial Drugs

Chemistry – A European Journal, EarlyView.
The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik, Nazlıcan Tunç, Senem Şen, Urartu Özgür Şafak Şeker   +3 more
wiley   +1 more source

Spotlight on the Nucleotide: Solid‐State NMR for the Investigation of ATP Hydrolysis in the ATPase SmsC

Chemistry – A European Journal, EarlyView.
Nucleotide‐detected solid‐state NMR has been applied to probe nucleotide conformations and dynamics during ATP hydrolysis using the dimeric P‐loop ATPase SmsC as a model protein. The different stages of ATP hydrolysis have been mimicked by ATP analogues for which different degrees of conformational heterogeneity have been observed. ABSTRACT Solid‐state
Nina Wehr, Laure Decamps, Julius Schlüter, Koen Linssen, Georg Künze, Kushal Sengupta, Serena DeBeer, Thomas Wiegand   +7 more
wiley   +1 more source

Genomic Insights Into Risperidone Treatment Outcomes in Children and Adolescents: Experience From a Psychiatric Hospital Serving Rural Youth

Clinical Pharmacology &Therapeutics, EarlyView.
Risperidone is a commonly used antipsychotic for treating psychiatric illness in children and adolescents. There is a large variability in risperidone response and discontinuation rates remain high. Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited.
Jack W. Staples, Shayna R. Killam, Karen E. Brown, Rachel Dalton, Elizabeth Sather, Qiang Chen, Joshua Loveland, Corbin Schwanke, Abdallah F. Elias, Kristin L. Bigos, Erica L. Woodahl   +10 more
wiley   +1 more source

ABCC8-associated with maturity-onset diabetes in a young woman: clinical features and genetic analysis

Сибирский научный медицинский журнал
ABCC8-MODY is caused by variants in the ATP-binding cassette transporter subfamily C member 8 (ABCC8) gene, which encodes sulfonylurea receptor 1 (SUR1), a subunit of the ATP-sensitive potassium channel (K-ATP) found in β-cell membranes.
O. D. Rymar, S. V. Mustafina, A. K. Ovsyannikova, E. V. Shakhtshneider, D. E. Ivanoshchuk, E. D. Ruzaeva, Yu. A. Dolinskaya, V. A. Stoyakina, A. A. Radionova   +8 more
doaj   +1 more source

Characterization of Lysosomal Hydrolases and Transporters and Their Age‐Dependent Variability: Relevance to Drug Metabolism and Transport of Small Molecule and Biologic Drugs

Clinical Pharmacology &Therapeutics, EarlyView.
Lysosomes play a key role in the accumulation, catabolism, and transport of endogenous and exogenous metabolites and proteins and are involved in drug metabolism and prodrug activation. However, the protein abundance and interindividual variability of lysosomal drug‐metabolizing enzymes and transporters (DMETs) remain underexplored.
Darshak Gadara, Dilip Kumar Singh, Sandhya Subash, Guihua Yue, Deepak Ahire, Chris Bohl, Maciej Czerwinski, Stephanie Helmstetter, Scott Heyward, Robert S. Jones, Cyrus Khojasteh, Ryota Kikuchi, Priyanka Kulkarni, Bin Ma, Bernard Murray, Chris Seib, Bill Smith, David M. Stresser, Mitchell E. Taub, Ting Wang, Bhagwat Prasad   +20 more
wiley   +1 more source

ATP-binding cassette transporter A1 (ABCA1) expression in adipose tissue and its modulation with insulin resistance in obesity

, 2019
Vinnyfred Vincent,1 Himani Thakkar,1 Sandeep Aggarwal,2 Asit Ranjan Mridha,3 Lakshmy Ramakrishnan,4 Archna Singh1 1Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India; 2Department of Surgical Disciplines, All India ...
Vincent V, Ramakrishnan L, Thakkar H, Aggarwal S, Singh A, Mridha AR   +5 more
core  

Elucidation of the structure and molecular mechanism of the tripartite multidrug efflux pumps in the Gram-negative pathogens: Vibrio cholerae and Neisseria gonorrhoeae [PDF]

, 2006
In bacteria, multidrug efflux systems have been identified as significant determinants of resistance recently. These resistance pumps are widely distributed in bacterial species and many pathogenic bacteria posses them, which play an important role in ...
Du, Dijun
core  

Mosaic activation of the zebrafish hsp70l heat shock promoter: Implications for interpreting transgenes

Developmental Dynamics, EarlyView.
Abstract Background The promoters and enhancers of heat shock genes, such as the 1.5‐kb promoter of the zebrafish hsp70l gene, are valuable tools for temporal activation of transgenes. It has been widely purported that heat shock treatments result in ubiquitous expression of hsp70l‐driven transgenes.
Jong‐Su Park, Xiangyun Wei
wiley   +1 more source

Reduced plasma high-density lipoprotein cholesterol in hyperthyroid mice coincides with decreased hepatic adenosine 5 '-triphosphate-binding cassette transporter 1 expression

, 2008
The aim of the study was to investigate the influence of severe hyperthyroidism on plasma high-density lipoprotein cholesterol (HDL-C). Recently, it was shown in mice that increasing doses of T(3) up-regulate hepatic expression of scavenger receptor ...
Fievet, Catherine, Hochegger, Kathrin, Stellaard, Frans, Tancevski, Ivan, Duwensee, Kristina, Ritsch, Andreas, Wehinger, Andreas, Eller, Philipp, Patsch, Josef R., Huber, Julia, Rudling, Mats, Schgoer, Wilfried, Demetz, Egon   +12 more
core   +1 more source