Results 131 to 140 of about 56,901 (159)

7-Ketocholesteryl-9-carboxynonanoate enhances ATP binding cassette transporter A1 expression mediated by PPARγ in THP-1 macrophages

Atherosclerosis, 2014
ATP binding cassette transporter A1 (ABCA1) is a member of the ATP-binding cassette transporter family. It plays an essential role in mediating the efflux of excess cholesterol. It is known that peroxisome proliferator-activated receptor gamma (PPARγ) promoted ABCA1 expression.
Yan, Chi, Le, Wang, Yuanyuan, Liu, Yanhua, Ma, Renjun, Wang, Xiaofei, Han, Hui, Qiao, Jiabin, Lin, Eiji, Matsuura, Shuqian, Liu, Qingping, Liu   +10 more
openaire   +2 more sources

Molecular Cloning of the Human ATP-Binding Cassette Transporter 1 (hABC1): Evidence for Sterol-Dependent Regulation in Macrophages

Biochemical and Biophysical Research Communications, 1999
We have cloned the full-length cDNA for the human ATP binding cassette transporter 1 (hABC1). The 6603-bp open reading frame encodes a polypeptide of 2201 amino acids resulting in a deduced molecular weight of 220 kDa. The hABC1 cDNA is highly homologous (62%) to the human rim ABC transporter (ABCR).
T, Langmann, J, Klucken, M, Reil, G, Liebisch, M F, Luciani, G, Chimini, W E, Kaminski, G, Schmitz   +7 more
openaire   +2 more sources

CEP-33779 antagonizes ATP-binding cassette subfamily B member 1 mediated multidrug resistance by inhibiting its transport function

Biochemical Pharmacology, 2014
The overexpression of ATP-binding cassette (ABC) transporters often leads to the development of multidrug resistance (MDR), which is the major factor contributing to the failure of chemotherapy. The objective of this study was to investigate the enhancement of CEP-33779, a small-molecule inhibitor of Janus kinase 2 (JAK2), on the efficacy of ...
Shang-jun, Tang, Li-kun, Chen, Fang, Wang, Yun-kai, Zhang, Zhen-cong, Huang, Kenneth Kin Wah, To, Xiao-kun, Wang, Tanaji T, Talele, Zhe-sheng, Chen, Wei-qiang, Chen, Li-wu, Fu   +10 more
openaire   +2 more sources

[Relationship between ATP-binding cassette transporter 1 R219K genetic variation and blood lipids].

Zhonghua yi xue za zhi, 2005
To investigate whether ATP-binding cassette transporter 1 (ABCA1) R219K genetic variation is correlated with blood lipids.Specimens of peripheral blood were collected from 692 patients with cerebral apoplexy, aged 62 +/- aged 12, and 352 sex- and age-matched persons without cardio-cerebro-vascular disease. Polymerase chain reaction-restricted fragments
Shui-Ping, Zhao, Zhi-Jie, Xiao, Quan-Zhong, Li, Sai, Nie, Li-Min, Tan, Bo, Jiang, Jun, Wu   +6 more
openaire   +1 more source

Insulin-like Growth Factor 1 Regulates the Expression of ATP-Binding Cassette Transporter A1 in Pancreatic Beta Cells

Hormone and Metabolic Research, 2016
ATP-binding cassette transporter A1 (ABCA1) in pancreatic beta cells influences insulin secretion and cholesterol homeostasis. The present study investigates whether insulin-like growth factor 1 (IGF-1), which mediates stimulation of ABCA1 gene expression, could also interfere with the phosphatidylinositol 3-kinase (PI3-K) cascade.ABCA1 expression was ...
J, Lyu, H, Imachi, H, Iwama, H, Zhang, K, Murao   +4 more
openaire   +2 more sources

Association of ATP binding cassette transporter 1 (ABCA 1) gene polymorphism with type 2 diabetes mellitus (T2DM) in Bangladeshi population

Gene, 2019
ATP-binding cassette transporter 1 (ABCA1) gene polymorphism has been reported as one of the genetic risk factors for T2DM in various populations with conflicting results. The aim of this study is to investigate the association of ABCA1 C69T polymorphism and lipid profile with T2DM in Bangladeshi population.A total of 102 T2DM subjects and 98 healthy ...
Md Mehedi, Hasan, Md Bayejid, Hosen, Md Mostafijur, Rahman, M Zakir Hossain, Howlader, Yearul, Kabir   +4 more
openaire   +2 more sources

Midkine Promote Atherosclerosis by Regulating the Expression of ATP-Binding Cassette Transporter A1 via Activator Protein-1

Cardiovascular Drugs and Therapy
Midkine (MK) has been shown to facilitate atherosclerotic plaque formation by downregulating the expression of ATP-binding cassette transporter A1 (ABCA1). However, the mechanism by which MK regulates ABCA1 to promote atherosclerosis remains incompletely understood.
Yixin Tang, Yaqin Cai, Fengling Peng, Ming Li, Zhongcheng Mo   +4 more
openaire   +2 more sources

[Relationship between the R219K polymorphism of ATP-binding cassette transporter 1 gene and coronary heart disease].

Yi chuan = Hereditas, 2008
To study the distribution of R219K polymorphism in ATP-Binding Cassette Transporter 1 (ABCA1) gene in Chinese Han population and the association of this polymorphism with coronary heart disease (CHD) . Genotypes were determined by PCR-RFLP approach in 417 unrelated healthy controls and 396 CHD patients.
Ya, Li, Si-Zhong, Zhang, Yong-Xin, Ma, Yong, He, Jing-Tao, Dong, Yan, Sun, Guo-Ping, He, Wei, Zhang   +7 more
openaire   +1 more source

Antisense Oligonucleotides Selectively Enter Human‐Derived Antibiotic‐Resistant Bacteria through Bacterial‐Specific ATP‐Binding Cassette Sugar Transporter

Advanced Materials, 2023
Binbin Chu, Jiaxu Hong, Houyu Wang
exaly  

Structure and Function of Hepatobiliary ATP Binding Cassette Transporters

Chemical Reviews, 2021
Sander H J Smits, Lutz Schmitt
exaly