Results 61 to 70 of about 56,901 (159)

The orphan nuclear receptor LRH-1 activates the ABCG5/ABCG8 intergenic promoter

Journal of Lipid Research, 2004
The ATP binding cassette (ABC) half-transporters ABCG5 and ABCG8 facilitate biliary and intestinal removal of neutral sterols. Here, we identify a binding site for the orphan nuclear receptor liver receptor homolog-1 (LRH-1) at nt 134–142 of the ABCG5 ...
Lita A. Freeman, Arion Kennedy, Justina Wu, Samantha Bark, Alan T. Remaley, Silvia Santamarina-Fojo, H. Bryan Brewer, Jr.   +6 more
doaj   +1 more source

Bruton’s Tyrosine Kinase (BTK) Inhibitor RN486 Overcomes ABCB1-Mediated Multidrug Resistance in Cancer Cells

Frontiers in Cell and Developmental Biology, 2020
Overexpression of ATP-binding cassette subfamily B member 1 (ABCB1) remains one of the most vital factors leading to multidrug resistance (MDR). It is important to enhance the effect and bioavailability of chemotherapeutic drugs that are substrates of ...
Xing-Duo Dong, Meng Zhang, Meng Zhang, Xiubin Ma, Jing-Quan Wang, Zi-Ning Lei, Qiu-Xu Teng, Yi-Dong Li, Lusheng Lin, Weiguo Feng, Weiguo Feng, Zhe-Sheng Chen   +11 more
doaj   +1 more source

Evaluation of Genome in Early Familial Coronary Artery Disease: A Case Report

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2019
Background and Objectives: Coronary artery diseases (CAD) are the most common cause of death in Iran and worldwide. Myocardial infarction (MI) is a complex multifactorial and the most severe type of CAD.
Mohammad Javad Ghorbani, Nematollah Razmi, Seyed Mohammad Bagher Tabei, Mohammad Javad Zibaeenezhad, Hamid Reza Goodarzi   +4 more
doaj  

ABCA7 rs3764650 Polymorphism is Associated with Delayed Neurocognitive Recovery

Pharmacogenomics and Personalized Medicine, 2022
Lu Yu,1 Haiyan Ji,2 Minmin Zhou,1 Yaxin Guo,2 Junfeng Liu,2 Daoyun Lei,3 Chao Han,1 Tieliang Ma1 1Department of Anesthesiology, Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, 214200, People’s Republic of China; 2Medical College of ...
Yu L, Ji H, Zhou M, Guo Y, Liu J, Lei D, Han C, Ma T   +7 more
doaj  

Pharmacokinetic Interaction of Green Rooibos Extract With Atorvastatin and Metformin in Rats

Frontiers in Pharmacology, 2019
An aspalathin-rich green rooibos extract (Afriplex GRT™) has demonstrated anti-diabetic and hypolipidemic properties, while also moderately inhibiting CYP3A4 activity, suggesting a potential for herb–drug interaction.
Oelfah Patel, Oelfah Patel, Christo J.F. Muller, Christo J.F. Muller, Christo J.F. Muller, Elizabeth Joubert, Elizabeth Joubert, Bernd Rosenkranz, Bernd Rosenkranz, Malcolm J.C. Taylor, Johan Louw, Johan Louw, Charles Awortwe, Charles Awortwe   +13 more
doaj   +1 more source

Crosslink among cyclin-dependent kinase 9, ATP binding cassette transporter G2 and Beclin 1 in colorectal cancer

World Journal of Gastrointestinal Oncology
Colorectal cancer (CRC) ranks third in the number of cancers mainly because of the inability to diagnose it at an early stage. The pathogenesis of CRC is complicated, which is the result of the complex interaction of multiple genetic and environmental factors. Currently, one of the main treatments for CRC is chemotherapy.
Shao, Zhong-Bao, He, Ke, Su, Yu-Bin, Shi, Zhi   +3 more
openaire   +2 more sources

ABCC8-associated with maturity-onset diabetes in a young woman: clinical features and genetic analysis

Сибирский научный медицинский журнал
ABCC8-MODY is caused by variants in the ATP-binding cassette transporter subfamily C member 8 (ABCC8) gene, which encodes sulfonylurea receptor 1 (SUR1), a subunit of the ATP-sensitive potassium channel (K-ATP) found in β-cell membranes.
O. D. Rymar, S. V. Mustafina, A. K. Ovsyannikova, E. V. Shakhtshneider, D. E. Ivanoshchuk, E. D. Ruzaeva, Yu. A. Dolinskaya, V. A. Stoyakina, A. A. Radionova   +8 more
doaj   +1 more source

DPP-4 Inhibitor Linagliptin Ameliorates Oxidized LDL-Induced THP-1 Macrophage Foam Cell Formation and Inflammation

Drug Design, Development and Therapy, 2020
Haoran Wang,1 Yue Li,2 Xiaoliang Zhang,2 Zhonglin Xu,2 Jianzhong Zhou,3 Wei Shang2 1Department of Endocrinology, The Ninth People’s Hospital of Chongqing, Chongqing 400700, People’s Republic of China; 2Department of Cardiology, The Ninth ...
Wang H, Li Y, Zhang X, Xu Z, Zhou J, Shang W   +5 more
doaj  

Generation and characterization of a Stargardt’s disease-specific induced pluripotent stem cell line (LVPEIi008-A) with a homozygous nonsense mutation in exon 44 of ABCA4

Stem Cell Research
The Stargardt’s Disease, Type 1 (STGD1) is associated with the loss of function mutations in ABCA4. This gene codes for a retina-specific, ATP-binding cassette (ABC) family transporter, involved in the transport of the key visual cycle intermediate, all ...
Divya Pidishetty, Savitri Maddileti, Sudipta Mahato, Trupti Agrawal, Milind Naik, Chitra Kannabiran, Subhadra Jalali, Indumathi Mariappan   +7 more
doaj   +1 more source