Results 41 to 50 of about 58,467 (240)

Therapeutic drugs modulate ATP-Binding cassette transporter-mediated transport of amyloid beta(1–42) in brain microvascular endothelial cells [PDF]

European Journal of Pharmacology, 2020
Deposition of amyloid-β peptide (Aβ(1-42)) is a hallmark of Alzheimer's disease. Clearance of Aβ(1-42), across the blood-brain barrier (BBB), is mediated by ATP-binding Cassette (ABC) efflux transporters. Many therapeutic drugs inhibit ABC transporters, but little is known of the effect of therapeutic drugs on Aβ(1-42) transport across BBB endothelial ...
Shubbar, Maryam, Penny, Jeffrey
openaire   +3 more sources

In vivo modulation of HDL phospholipid has opposing effects on SR-BI- and ABCA1-mediated cholesterol efflux

Journal of Lipid Research, 2004
The effects of in vivo modulation of HDL phospholipid (PL) on scavenger receptor class BI (SR-BI)- and ATP binding cassette transporter 1 (ABCA1)-mediated efflux were examined by overexpressing either endothelial lipase (EL) or phosphatidylserine ...
Patricia G. Yancey, Masa-aki Kawashiri, Ryan Moore, Jane M. Glick, David L. Williams, Margery A. Connelly, Daniel J. Rader, George H. Rothblat   +7 more
doaj   +1 more source

Up-regulation of ATP-binding cassette transporters in the THP-1 human macrophage cell line by the antichagasic benznidazole [PDF]

Memórias do Instituto Oswaldo Cruz, 2016
تم تقييم تأثير البنزنيدازول (BZL) على تعبير ونشاط البروتين السكري P (P - gp، ABCB1) والبروتين المرتبط بمقاومة الأدوية المتعددة 2 (MRP2، ABCC2)، وهما الناقلان الرئيسيان للمركبات الداخلية والخارجية، في خلايا THP -1 المتمايزة. قام Bzl بتحفيز بروتينات P - gp و MRP2 بطريقة تعتمد على التركيز.
Virginia Perdomo, Juan Pablo Rigalli, Marcelo G. Luquita, José M Pellegrino, María Laura Ruiz, Viviana A. Catania   +5 more
openaire   +4 more sources

Generation of an urine-derived induced pluripotent stem cell line from a 6-year old X-linked adrenoleukodystrophy (X-ALD) patient

Stem Cell Research, 2021
The gene mutations of the ATP-binding-cassette transporter subfamily D member 1 (ABCD1) can lead to the inherited neuro-metabolic malfunction disease X-linked adrenoleukodystrophy (X-ALD).
Long Wang, Beibei Gao, Xuming Mo, Xiaoling Guo, Jinyu Huang   +4 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Multidrug Resistance Protein 1 (MRP1, ABCC1), a “Multitasking” ATP-binding Cassette (ABC) Transporter [PDF]

Journal of Biological Chemistry, 2014
The multidrug resistance protein 1 (MRP1) encoded by ABCC1 was originally discovered as a cause of multidrug resistance in tumor cells. However, it is now clear that MRP1 serves a broader role than simply mediating the ATP-dependent efflux of drugs from cells. The antioxidant GSH and the pro-inflammatory cysteinyl leukotriene C4 have been identified as
openaire   +2 more sources

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

Advanced Healthcare Materials, EarlyView.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith, Anderson Scott, Cynthia Hajal, Paula T. Hammond, Joelle P. Straehla   +7 more
wiley   +1 more source

Wearable OLED‐Assisted Photodynamic Cancer Therapy Using Chlorin e6‐Loaded Pluronic Nanocapsules as Photosensitizers

Advanced Healthcare Materials, EarlyView.
A novel photodynamic therapeutic approach has been employed for anticancer therapy, utilizing chlorin e6‐loaded Pluronic nanocapsules and a wearable organic light‐emitting diode light source. This has shown significant in vivo antitumor efficacy with minimal off‐target toxicity. The innovative combination of a wearable light source and photosensitizers
Hyeryeon Oh, Seung Min Jeong, Cheol Hui Park, Panmo Son, Yeseo Lee, Heebeom Koo, Won Il Choi, Kyung Cheol Choi   +7 more
wiley   +1 more source