Results 21 to 30 of about 58,467 (240)

Native LDL Upregulation of ATP-Binding Cassette Transporter-1 in Human Vascular Endothelial Cells [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2002
ATP-binding cassette transporter-1 (ABCA1) mediates the lipid efflux from cells to apolipoproteins. In studying the gene expression and regulation of ABCA1 in human vascular endothelial cells (ECs), we found that native low density lipoprotein (LDL) elevates ABCA1 in both protein and mRNA levels in a time- and dose-dependent fashion.
Hailing, Liao, Thomas, Langmann, Gerd, Schmitz, Yi, Zhu   +3 more
openaire   +2 more sources

Proteomic strategy for the analysis of the polychlorobiphenyl-degrading cyanobacterium Anabaena PD-1 exposed to Aroclor 1254.

PLoS ONE, 2014
The cyanobacterium Anabaena PD-1, which was originally isolated from polychlorobiphenyl (PCB)-contaminated paddy soils, has capabilities for dechlorinatin and for degrading the commercial PCB mixture Aroclor 1254.
Hangjun Zhang, Xiaojun Jiang, Wenfeng Xiao, Liping Lu   +3 more
doaj   +1 more source

Overexpression of ABCC1 Confers Drug Resistance to Betulin

Frontiers in Oncology, 2021
Betulin is a lupane-type pentacyclic triterpene, which is isolated from birch bark. It has a broad spectrum of biological and pharmacological properties, such as anti-inflammatory, anti-tumor, anti-viral, and anti-bacterial activity.
Xuan-Yu Chen, Xuan-Yu Chen, Yuqi Yang, Jing-Quan Wang, Zhuo-Xun Wu, Jing Li, Zhe-Sheng Chen   +6 more
doaj   +1 more source

ATP Binding Cassette Transporter A1 is Involved in Extracellular Secretion of Acetylated APE1/Ref-1 [PDF]

International Journal of Molecular Sciences, 2019
Acetylation of nuclear apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE1/Ref-1) is associated with its extracellular secretion, despite the lack of an N-terminal protein secretion signal. In this study, we investigated plasma membrane targeting and translocation of APE1/Ref-1 in HEK293T cells with enhanced acetylation.
Yu Lee, Hee Joo, Eun Lee, Hyun Cho, Sunga Choi, Cuk-Seong Kim, Byeong Jeon   +6 more
openaire   +2 more sources

Intestinal cholesterol absorption is substantially reduced in mice deficient in both ABCA1 and ACAT2

Journal of Lipid Research, 2005
The process of cholesterol absorption has yet to be completely defined at the molecular level. Because of its ability to esterify cholesterol for packaging into nascent chylomicrons, ACAT2 plays an important role in cholesterol absorption.
Ryan E. Temel, Richard G. Lee, Kathryn L. Kelley, Matthew A. Davis, Ramesh Shah, Janet K. Sawyer, Martha D. Wilson, Lawrence L. Rudel   +7 more
doaj   +1 more source

Chalcone Derivatives Enhance ATP-Binding Cassette Transporters A1 in Human THP-1 Macrophages [PDF]

Molecules, 2018
Atherosclerosis is a process of imbalanced lipid metabolism in the vascular walls. The underlying pathology mainly involves the deposition of oxidized lipids in the endothelium and the accumulation of cholesterol in macrophages. Macrophages export excessive cholesterol (cholesterol efflux) through ATP-binding cassette transporter A1 (ABCA1) to counter ...
Teng, I-Jou, Tsai, Min-Chien, Shih, Shao-Fu, Tsuei, Bi-Feng, Chang, Hsin, Chuang, Yi-Ping, Lin, Chin-Sheng, Chern, Ching-Yuh, Chen, Sy-Jou   +8 more
openaire   +3 more sources

Generation of an induced pluripotent stem cell (iPSC) line from a 42-year-old adult cerebral type X-linked adrenoleukodystrophy (X-ALD) patient

Stem Cell Research, 2019
X-linked Adrenoleukodystrophy (X-ALD) is a neuro-metabolic disorder that is caused by malfunction of a peroxisomal transporter protein, adenosine ATP-binding cassette transporter superfamily D member 1 (ABCD1).
Gyu-Bum Yeon, Daryeon Son, Phil Jun Kang, Seung-Min Oh, Hun Lim, Hoon-Chul Kang, Seungkwon You, Dae-Sung Kim   +7 more
doaj   +1 more source

Modulating the function of ABCB1: in vitro and in vivo characterization of sitravatinib, a tyrosine kinase inhibitor

Cancer Communications, 2020
Background Overexpression of ATP‐binding cassette (ABC) transporter is a major contributor to multidrug resistance (MDR), in which cancer cells acquire resistance to a wide spectrum of chemotherapeutic drugs.
Yuqi Yang, Ning Ji, Chao‐Yun Cai, Jing‐Quan Wang, Zi‐Ning Lei, Qiu‐Xu Teng, Zhuo‐Xun Wu, Qingbin Cui, Yihang Pan, Zhe‐Sheng Chen   +9 more
doaj   +1 more source

Novel Gene Mutation in a Korean Patient with X-Linked Adrenoleukodystrophy Presenting with Addison's Disease [PDF]

Endocrinology and Metabolism, 2020
X-linked adrenoleukodystrophy (X-ALD) occurs due to mutations in the ABCD1 gene that encodes the peroxisomal membrane protein peroxisomal transporter ATP-binding cassette sub-family D member 1 (ABCD1).
Yun Kyung Cho, Seo-Young Lee, Sang-Wook Kim   +2 more
doaj   +1 more source

Retinoid Binding Properties of Nucleotide Binding Domain 1 of the Stargardt Disease-associated ATP Binding Cassette (ABC) Transporter, ABCA4 [PDF]

Journal of Biological Chemistry, 2012
The retina-specific ATP binding cassette transporter, ABCA4 protein, is associated with a broad range of inherited macular degenerations, including Stargardt disease, autosomal recessive cone rod dystrophy, and fundus flavimaculatus. In order to understand its role in retinal transport in rod out segment discs, we have investigated the interactions of ...
Esther E, Biswas-Fiss, Stephanie, Affet, Malissa, Ha, Subhasis B, Biswas   +3 more
openaire   +2 more sources