Results 21 to 30 of about 60,219 (305)

Stanol esters decrease plasma cholesterol independently of intestinal ABC sterol transporters and Niemann-Pick C1-like 1 protein gene expression

Journal of Lipid Research, 2004
Possible mechanisms for the cholesterol-lowering effects of plant stanol esters were addressed by feeding hamsters diets containing stanol esters, cholesterol, or cholestyramine/lovastatin.
F. Jeffrey Field, Ella Born, Satya N. Mathur   +2 more
doaj   +1 more source

Glycolysis inhibition inactivates ABC transporters to restore drug sensitivity in malignant cells. [PDF]

PLoS ONE, 2011
Cancer cells eventually acquire drug resistance largely via the aberrant expression of ATP-binding cassette (ABC) transporters, ATP-dependent efflux pumps.
Ayako Nakano, Daisuke Tsuji, Hirokazu Miki, Qu Cui, Salah Mohamed El Sayed, Akishige Ikegame, Asuka Oda, Hiroe Amou, Shingen Nakamura, Takeshi Harada, Shiro Fujii, Kumiko Kagawa, Kyoko Takeuchi, Akira Sakai, Shuji Ozaki, Kazuma Okano, Takahiro Nakamura, Kohji Itoh, Toshio Matsumoto, Masahiro Abe   +19 more
doaj   +1 more source

Native LDL Upregulation of ATP-Binding Cassette Transporter-1 in Human Vascular Endothelial Cells [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2002
ATP-binding cassette transporter-1 (ABCA1) mediates the lipid efflux from cells to apolipoproteins. In studying the gene expression and regulation of ABCA1 in human vascular endothelial cells (ECs), we found that native low density lipoprotein (LDL) elevates ABCA1 in both protein and mRNA levels in a time- and dose-dependent fashion.
Hailing, Liao, Thomas, Langmann, Gerd, Schmitz, Yi, Zhu   +3 more
openaire   +2 more sources

Overexpression of ABCC1 Confers Drug Resistance to Betulin

Frontiers in Oncology, 2021
Betulin is a lupane-type pentacyclic triterpene, which is isolated from birch bark. It has a broad spectrum of biological and pharmacological properties, such as anti-inflammatory, anti-tumor, anti-viral, and anti-bacterial activity.
Xuan-Yu Chen, Xuan-Yu Chen, Yuqi Yang, Jing-Quan Wang, Zhuo-Xun Wu, Jing Li, Zhe-Sheng Chen   +6 more
doaj   +1 more source

Midostaurin Reverses ABCB1-Mediated Multidrug Resistance, an in vitro Study

Frontiers in Oncology, 2019
Overexpression of ABC transporters in cancer cells is an underlying mechanism of multidrug resistance (MDR), leading to insensitive response to chemotherapeutic strategies. Thus, MDR is often results in treatment failure in the clinic.
Ning Ji, Ning Ji, Yuqi Yang, Chao-Yun Cai, Jing-Quan Wang, Zi-Ning Lei, Zhuo-Xun Wu, Qingbin Cui, Dong-Hua Yang, Zhe-Sheng Chen, Dexin Kong, Dexin Kong   +11 more
doaj   +1 more source

Chalcone Derivatives Enhance ATP-Binding Cassette Transporters A1 in Human THP-1 Macrophages [PDF]

Molecules, 2018
Atherosclerosis is a process of imbalanced lipid metabolism in the vascular walls. The underlying pathology mainly involves the deposition of oxidized lipids in the endothelium and the accumulation of cholesterol in macrophages. Macrophages export excessive cholesterol (cholesterol efflux) through ATP-binding cassette transporter A1 (ABCA1) to counter ...
I-Jou Teng, Min-Chien Tsai, Shao-Fu Shih, Bi-Feng Tsuei, Hsin Chang, Yi-Ping Chuang, Chin-Sheng Lin, Ching-Yuh Chern, Sy-Jou Chen   +8 more
openaire   +3 more sources

Proteomic strategy for the analysis of the polychlorobiphenyl-degrading cyanobacterium Anabaena PD-1 exposed to Aroclor 1254.

PLoS ONE, 2014
The cyanobacterium Anabaena PD-1, which was originally isolated from polychlorobiphenyl (PCB)-contaminated paddy soils, has capabilities for dechlorinatin and for degrading the commercial PCB mixture Aroclor 1254.
Hangjun Zhang, Xiaojun Jiang, Wenfeng Xiao, Liping Lu   +3 more
doaj   +1 more source

Intestinal cholesterol absorption is substantially reduced in mice deficient in both ABCA1 and ACAT2

Journal of Lipid Research, 2005
The process of cholesterol absorption has yet to be completely defined at the molecular level. Because of its ability to esterify cholesterol for packaging into nascent chylomicrons, ACAT2 plays an important role in cholesterol absorption.
Ryan E. Temel, Richard G. Lee, Kathryn L. Kelley, Matthew A. Davis, Ramesh Shah, Janet K. Sawyer, Martha D. Wilson, Lawrence L. Rudel   +7 more
doaj   +1 more source

Rustless translation [PDF]

, 2012
ATP binding cassette proteins are a large and diverse family of molecular machines and include transmembrane transporter, chromosome maintenance and DNA repair proteins, and translation factors.
Hopfner, Karl-Peter
core   +1 more source

Generation of an induced pluripotent stem cell (iPSC) line from a 42-year-old adult cerebral type X-linked adrenoleukodystrophy (X-ALD) patient

Stem Cell Research, 2019
X-linked Adrenoleukodystrophy (X-ALD) is a neuro-metabolic disorder that is caused by malfunction of a peroxisomal transporter protein, adenosine ATP-binding cassette transporter superfamily D member 1 (ABCD1).
Gyu-Bum Yeon, Daryeon Son, Phil Jun Kang, Seung-Min Oh, Hun Lim, Hoon-Chul Kang, Seungkwon You, Dae-Sung Kim   +7 more
doaj   +1 more source