Results 31 to 40 of about 58,467 (240)

Scavenger Receptor-BI Inhibits ATP-binding Cassette Transporter 1- mediated Cholesterol Efflux in Macrophages [PDF]

Journal of Biological Chemistry, 2000
Scavenger receptor BI (SR-BI) facilitates the efflux of cellular cholesterol to plasma high density lipoprotein (HDL). Recently, the ATP-binding cassette transporter 1 (ABC1) was identified as a key mediator of cholesterol efflux to apolipoproteins and HDL. The goal of the present study was to determine a possible interaction between the SR-BI and ABC1
W, Chen, D L, Silver, J D, Smith, A R, Tall   +3 more
openaire   +2 more sources

The Mechanism Underlying the Synergetic Hypocholesterolemic Effect of Sesamin and α-Tocopherol in Rats Fed a High-Cholesterol Diet

Journal of Pharmacological Sciences, 2011
Sesamin is a major lignan in sesame seed. We confirmed that ingestion of sesamin and α-tocopherol synergistically reduced the concentration of blood cholesterol in rats given a high-cholesterol diet.
Tomohiro Rogi, Namino Tomimori, Yoshiko Ono, Yoshinobu Kiso   +3 more
doaj   +1 more source

Reversal of ABCB1-related multidrug resistance by ERK5-IN-1

Journal of Experimental & Clinical Cancer Research, 2020
Background Inhibition of ABC transporters is considered the most effective way to circumvent multidrug resistance (MDR). In the present study, we evaluated the MDR modulatory potential of ERK5-IN-1, a potent extracelluar signal regulated kinase 5 (ERK5 ...
Fang Wang, Delan Li, ZongHeng Zheng, Kenneth Kin Wah To, Zhen Chen, Mengjun Zhong, Xiaodong Su, Likun Chen, Liwu Fu   +8 more
doaj   +1 more source

Generation of two induced pluripotent stem cell (iPSC) lines from X-linked adrenoleukodystrophy (X-ALD) patients with adrenomyeloneuropathy (AMN)

Stem Cell Research, 2017
X-linked adrenoleukodystrophy (X-ALD) is an inherited disorder caused by a mutation in the ATP-binding cassette transporter subfamily D member 1 (ABCD1) gene.
Daryeon Son, Zhejiu Quan, Phil Jun Kang, Gyuman Park, Hoon-Chul Kang, Seungkwon You   +5 more
doaj   +1 more source

Apolipoprotein A1-Related Proteins and Reverse Cholesterol Transport in Antiatherosclerosis Therapy: Recent Progress and Future Perspectives

Cardiovascular Therapeutics, 2022
Hyperlipidemia characterized by abnormal deposition of cholesterol in arteries can cause atherosclerosis and coronary artery occlusion, leading to atherosclerotic coronary heart disease.
Xiuting Xu, Zikai Song, Bao Mao, Guoliang Xu   +3 more
doaj   +1 more source

Comparative transcriptomics provides novel insights into the mechanisms of selenium accumulation and transportation in tea cultivars (Camellia sinensis (L.) O. Kuntze)

Frontiers in Plant Science, 2023
Tea plants (Camellia sinensis) show discrepancies in selenium accumulation and transportation, the molecular mechanisms of which are not well understood.
Qinghua Zheng, Lina Guo, Jianyan Huang, Xinyuan Hao, Xiaoman Li, Nana Li, Yueqi Wang, Kexin Zhang, Xinchao Wang, Lu Wang, Jianming Zeng   +10 more
doaj   +1 more source

A single high-dose irradiation changes accumulation of methotrexate and gene expression levels of SLC and ABC transporters in cancer cells

Frontiers in Pharmacology, 2023
Chemoradiotherapy is frequently used to treat cancer. Stereotactic body radiotherapy (SBRT) is a single high-dose radiotherapy used to treat a variety of cancers.
Kakeru Sato, Tatsuya Seki, Asuka Mizutani, Yuka Muranaka, Shiho Hirota, Kodai Nishi, Kana Yamazaki, Ryuichi Nishii, Takeo Nakanishi, Ikumi Tamai, Keiichi Kawai, Keiichi Kawai, Masato Kobayashi   +12 more
doaj   +1 more source

Amentoflavone-Enriched Selaginella rossii Warb. Suppresses Body Weight and Hyperglycemia by Inhibiting Intestinal Lipid Absorption in Mice Fed a High-Fat Diet

Life, 2022
Many Selaginellaceae species are used as traditional medicines in Asia. This study is the first to investigate the anti-obesity and anti-diabetic effects of Selaginella rossii (SR) in high-fat diet (HFD)–fed C57BL/6J mice.
Hwa Lee, Seona Cho, Soo-Yong Kim, Jeongha Ju, Sang Woo Lee, Sangho Choi, Hulin Li, Renzhe Piao, Ho-Yong Park, Tae-Sook Jeong   +9 more
doaj   +1 more source

ATP-binding cassette transporter 1 and Transglutaminase 2 act on the same genetic pathway in the apoptotic cell clearance [PDF]

Cell Death & Differentiation, 2006
ATP-binding cassette transporter 1 and Transglutaminase 2 act on the same genetic pathway in the apoptotic cell ...
Iadevaia, V., Rinaldi, A., Falasca, L., Pucillo, L. P., Alonzi, T., Chimini, G., Piacentini, M.   +6 more
openaire   +3 more sources

Influence of (ATP)-Binding Cassette Transporter Subfamily B Member 1 (ABCB1) Gene Polymorphism on the Efficacy of Remifentanil [PDF]

Medical Science Monitor, 2019
BACKGROUND The aim of this study was to investigate the influence of adenosine triphosphate (ATP)-binding cassette transporter subfamily B member 1 (ABCB1) gene polymorphism on the efficacy of Remifentanil. MATERIAL AND METHODS A total of 276 patients undergoing elective surgeries were included to collect general clinical information and detect the ...
Wang, Wenzhu, Zhou, Qinghua, Yuan, Changxiu   +2 more
openaire   +2 more sources