Results 11 to 20 of about 60,219 (305)

ATP Binding Cassette Transporter A1 is Involved in Extracellular Secretion of Acetylated APE1/Ref-1 [PDF]

International Journal of Molecular Sciences, 2019
Acetylation of nuclear apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE1/Ref-1) is associated with its extracellular secretion, despite the lack of an N-terminal protein secretion signal. In this study, we investigated plasma membrane targeting and translocation of APE1/Ref-1 in HEK293T cells with enhanced acetylation.
Yu Lee, Hee Joo, Eun Lee, Hyun Cho, Sunga Choi, Cuk-Seong Kim, Byeong Jeon   +6 more
openaire   +3 more sources

Increased protein expression of ABCA1, HMG-CoA reductase, and CYP46A1 induced by garlic and allicin in the brain mouse and astrocytes-isolated from C57BL/6J [PDF]

Avicenna Journal of Phytomedicine, 2021
Objective: Regulation of cholesterol level is essential for the brain optimal function. The beneficial effect of garlic consumption on cholesterol homeostasis is well known; however, the molecular mechanism to support its properties is unclear.
Zahra Nazeri, Shirin Azizidoost, Maryam Cheraghzadeh, Asma Mohammadi, Alireza Kheirollah   +4 more
doaj   +1 more source

New Strategies to Promote Macrophage Cholesterol Efflux

Frontiers in Cardiovascular Medicine, 2021
The capacity of macrophages to dispose of cholesterol deposited in the atherosclerotic plaque depends on their ability to activate cholesterol efflux pathways.
Hong Y. Choi, Isabelle Ruel, Shiwon Choi, Jacques Genest   +3 more
doaj   +1 more source

Molecular interaction of nitrate transporter proteins with recombinant glycinebetaine results in efficient nitrate uptake in the cyanobacterium Anabaena PCC 7120.

PLoS ONE, 2021
Nitrate transport in cyanobacteria is mediated by ABC-transporter, which consists of a highly conserved ATP binding cassette (ABC) and a less conserved transmembrane domain (TMD).
Prashant Swapnil, Mukesh Meena, Ashwani K Rai   +2 more
doaj   +2 more sources

CLONING OF A GENE ENCODING PROTEIN BELONGING TO ABC TRANSPORTER INVOLVED IN BACTERIAL MAGNETIC PARTICLE SYNTHESIS IN MAGNETOSPIRILLUM MAGNETICUM AMB-1

Biotropia: The Southeast Asian Journal of Tropical Biology, 2009
Magnetospirillum magneticum AMB-1 synthesizes intracellular magnetic particles, magnetite (Fe3 O4 ), enveloped by membrane called magnetosome under micro-aerobic conditions.
ARIS TRI WAHYUDI
doaj   +3 more sources

Localization of Human ATP-Binding Cassette Transporter 1 (ABC1) in Normal and Atherosclerotic Tissues [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2001
Abstract —The present study examines the expression of ATP-binding cassette transporter 1 (ABC1) mRNA in normal and atherosclerotic tissues by using in situ hybridization in an effort to better understand the function of this cholesterol transport protein.
R M, Lawn, D P, Wade, T L, Couse, J N, Wilcox   +3 more
openaire   +2 more sources

ATP-Binding Cassette Transporter 1 Participates in LDL Oxidation by Artery Wall Cells [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2002
Objective—We have previously reported that products of the lipoxygenase pathway, hydroperoxyoctadecadienoic acid and hydroperoxyeicosatetraenoic acid, as well as cholesterol linoleate hydroperoxides, collectively termed seeding molecules, are removed by apolipoprotein A-I (apoA-I) from the artery wall cells and render low density lipoprotein (LDL ...
Srinivasa T, Reddy, Susan, Hama, Carey, Ng, Victor, Grijalva, Mohamad, Navab, Alan M, Fogelman   +5 more
openaire   +2 more sources

Inhibitors of ABCB1 and ABCG2 overcame resistance to topoisomerase inhibitors in small cell lung cancer

Thoracic Cancer, 2022
Background Small cell lung cancer (SCLC) is a highly aggressive disease with a poor prognosis. Although most patients initially respond to topoisomerase inhibitors, resistance rapidly emerges.
Miwako Omori, Rintaro Noro, Masahiro Seike, Kuniko Matsuda, Mariko Hirao, Aya Fukuizumi, Natsuki Takano, Akihiko Miyanaga, Akihiko Gemma   +8 more
doaj   +1 more source

Activation of NLRP3 Inflammasome Promotes Foam Cell Formation in Vascular Smooth Muscle Cells and Atherogenesis Via HMGB1

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background This study aimed at investigating whether NLRP3 (the Nod like receptor family, pyrin domain‐containing 3 protein) inflammasome activation induced HMGB1 (high mobility group box‐1 protein) secretion and foam cell formation in human vascular ...
Rui Wang, Weibin Wu, Wen Li, Shuichuan Huang, Zilun Li, Ruiming Liu, Zhen Shan, Chunxiang Zhang, Wen Li, Shenming Wang   +9 more
doaj   +1 more source

Nucleotide-Binding Sites of the Heterodimeric LmrCD ABC-Multidrug Transporter of Lactococcus lactis Are Asymmetric [PDF]

, 2006
LmrCD is a lactococcal, heterodimeric multidrug transporter, which belongs to the ABC superfamily. It consists of two half-transporters, LmrC and LmrD, that are necessary and sufficient for drug extrusion and ATP hydrolysis.
Konings, Wil N., Lubelski, Jacek, Konings, Wil N.,, Merkerk, Ronald van, Lubelski, Jacek,, Merkerk, Ronald van,, Driessen, Arnold J.M.,, Driessen, Arnold J.M.   +7 more
core   +1 more source