Results 11 to 20 of about 58,467 (240)

ATP-Binding Cassette Transporter 1 Attenuates Ovalbumin-Induced Neutrophilic Airway Inflammation [PDF]

American Journal of Respiratory Cell and Molecular Biology, 2014
Abstract Apolipoprotein A-I (apoA-I) is an important component of high-density lipoprotein particles that mediates reverse cholesterol transport out of cells by interacting with the ATP-binding cassette transporter 1 (ABCA1). apoA-I has also been shown to attenuate neutrophilic airway inflammation in experimental ovalbumin (OVA ...
Cuilian, Dai, Xianglan, Yao, Boris, Vaisman, Todd, Brenner, Katharine S, Meyer, Meixia, Gao, Karen J, Keeran, Gayle Z, Nugent, Xuan, Qu, Zu-Xi, Yu, Pradeep K, Dagur, J Philip, McCoy, Alan T, Remaley, Stewart J, Levine   +13 more
europepmc   +5 more sources

The ATP-binding cassette transporter 1 mediates lipid efflux from Sertoli cells and influences male fertility [PDF]

Journal of Lipid Research, 2004
The liver X receptor/retinoid X receptor (LXR/RXR)-regulated gene ABCA1 effluxes cellular cholesterol and phospholipid to apolipoprotein A1 (apoA1), which is the rate-limiting step in high-density lipoprotein synthesis.
David M. Selva, Veronica Hirsch-Reinshagen, Braydon Burgess, Steven Zhou, Jeniffer Chan, Sean McIsaac, Michael R. Hayden, Geoffrey L. Hammond, A. Wayne Vogl, Cheryl L. Wellington   +9 more
doaj   +3 more sources

D-helix influences dimerization of the ATP-binding cassette (ABC) transporter associated with antigen processing 1 (TAP1) nucleotide-binding domain. [PDF]

PLoS ONE, 2017
ATP-binding cassette (ABC) transporters form a large family of transmembrane importers and exporters. Using two nucleotide-binding domains (NBDs), which form a canonical ATP-sandwich dimer at some point within the transport cycle, the transporters ...
Ahmet S Vakkasoglu, Sriram Srikant, Rachelle Gaudet   +2 more
doaj   +6 more sources

Role of ATP-binding cassette transporter A1 in suppressing lipid accumulation by glucagon-like peptide-1 agonist in hepatocytes

Molecular Metabolism, 2020
Objective: Adenosine triphosphate (ATP)-binding cassette transporter A1 (ABCA1) influences hepatic cholesterol transportation. Accumulation of hepatic cholesterol leads to fatty liver disease, which is improved by glucagon-like peptide 1 (GLP-1) in ...
Jingya Lyu, Hitomi Imachi, Kensaku Fukunaga, Seisuke Sato, Toshihiro Kobayashi, Tao Dong, Takanobu Saheki, Mari Matsumoto, Hisakazu Iwama, Huanxiang Zhang, Koji Murao   +10 more
doaj   +3 more sources

DeepRTCP: Predicting ATP-Binding Cassette Transporters Based on 1-Dimensional Convolutional Network [PDF]

Frontiers in Cell and Developmental Biology, 2021
ATP-binding cassette (ABC) transporters can promote cells to absorb nutrients and excrete harmful substances. It plays a vital role in the transmembrane transport of macromolecules. Therefore, the identification of ABC transporters is of great significance for the biological research. This paper will introduce a novel method called DeepRTCP.
Zhaoxi Zhang, Juan Wang, Juan Wang, Jiameng Liu   +3 more
openaire   +3 more sources

Asymmetric Conformational Flexibility in the ATP-Binding Cassette Transporter HI1470/1 [PDF]

Biophysical Journal, 2009
Putative metal-chelate-type ABC transporter HI1470/1 is homologous with vitamin B(12) importer BtuCD but exhibits a distinct inward-facing conformation in contrast to the outward-facing conformation of BtuCD. Normal-mode analysis of HI1470/1 reveals the intrinsic asymmetric conformational flexibility in this transporter and demonstrates that the ...
Weng, Jingwei, Ma, Jianpeng, Fan, Kangnian, Wang, Wenning   +3 more
openaire   +2 more sources

Localization of Human ATP-Binding Cassette Transporter 1 (ABC1) in Normal and Atherosclerotic Tissues [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2001
Abstract —The present study examines the expression of ATP-binding cassette transporter 1 (ABC1) mRNA in normal and atherosclerotic tissues by using in situ hybridization in an effort to better understand the function of this cholesterol transport protein.
R M, Lawn, D P, Wade, T L, Couse, J N, Wilcox   +3 more
openaire   +2 more sources

ATP-Binding Cassette Transporter 1 Participates in LDL Oxidation by Artery Wall Cells [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2002
Objective—We have previously reported that products of the lipoxygenase pathway, hydroperoxyoctadecadienoic acid and hydroperoxyeicosatetraenoic acid, as well as cholesterol linoleate hydroperoxides, collectively termed seeding molecules, are removed by apolipoprotein A-I (apoA-I) from the artery wall cells and render low density lipoprotein (LDL ...
Srinivasa T, Reddy, Susan, Hama, Carey, Ng, Victor, Grijalva, Mohamad, Navab, Alan M, Fogelman   +5 more
openaire   +2 more sources

Glycolysis inhibition inactivates ABC transporters to restore drug sensitivity in malignant cells. [PDF]

PLoS ONE, 2011
Cancer cells eventually acquire drug resistance largely via the aberrant expression of ATP-binding cassette (ABC) transporters, ATP-dependent efflux pumps.
Ayako Nakano, Daisuke Tsuji, Hirokazu Miki, Qu Cui, Salah Mohamed El Sayed, Akishige Ikegame, Asuka Oda, Hiroe Amou, Shingen Nakamura, Takeshi Harada, Shiro Fujii, Kumiko Kagawa, Kyoko Takeuchi, Akira Sakai, Shuji Ozaki, Kazuma Okano, Takahiro Nakamura, Kohji Itoh, Toshio Matsumoto, Masahiro Abe   +19 more
doaj   +1 more source

Midostaurin Reverses ABCB1-Mediated Multidrug Resistance, an in vitro Study

Frontiers in Oncology, 2019
Overexpression of ABC transporters in cancer cells is an underlying mechanism of multidrug resistance (MDR), leading to insensitive response to chemotherapeutic strategies. Thus, MDR is often results in treatment failure in the clinic.
Ning Ji, Ning Ji, Yuqi Yang, Chao-Yun Cai, Jing-Quan Wang, Zi-Ning Lei, Zhuo-Xun Wu, Qingbin Cui, Dong-Hua Yang, Zhe-Sheng Chen, Dexin Kong, Dexin Kong   +11 more
doaj   +1 more source