ATP-citrate lyase promotes axonal transport across species [PDF]
Nature Communications, 2021 Microtubule tracks are important for the transport of molecules within axons. Here, the authors show that ATAT1, the enzyme responsible for acetylating a-tubulin, receives acetyl groups from ATP citrate lyase whose stability is regulated by Elongator, a ...
Aviel Even +18 more
doaj +7 more sources
Allosteric role of the citrate synthase homology domain of ATP citrate lyase [PDF]
Nature Communications, 2023 ATP citrate lyase (ACLY) is the predominant nucleocytosolic source of acetyl-CoA and is aberrantly regulated in many diseases making it an attractive therapeutic target.
Xuepeng Wei +6 more
doaj +4 more sources
ATP Citrate Lyase ClACLB-1 Facilitates Citrate Cleavage in Lemon [PDF]
PlantsCitric acid is an important organic acid with wide applications and diverse biological functionality. As the predominant organic acid in lemons, citric acid plays a crucial role in determining the flavor of citrus, especially in lemons. ATP citrate lyase
Chuang Lu +8 more
doaj +3 more sources
Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques [PDF]
Nature Communications, 2020 Inhibition of the metabolic enzyme ATP-citrate lyase can attenuate atherosclerosis by preventing dyslipidemia and potentially also by reducing macrophage-mediated inflammation. Here, the authors show that specific targeting of ACLY in macrophages results
Jeroen Baardman +19 more
doaj +7 more sources
ATP-Citrate Lyase in Heart Failure [PDF]
JACC: Basic to Translational ScienceDavid Weissman, MSc, Christoph Maack, MD
doaj +4 more sources
Expanded Interactome of the Intrinsically Disordered Protein Dss1 [PDF]
Cell Reports, 2018 Summary: Dss1 (also known as Sem1) is a conserved, intrinsically disordered protein with a remarkably broad functional diversity. It is a proteasome subunit but also associates with the BRCA2, RPA, Csn12-Thp1, and TREX-2 complexes.
Signe M. Schenstrøm +7 more
doaj +5 more sources
ATP Citrate Lyase is a General Tumour Biomarker and Contributes to the Development of Cutaneous Squamous Cell Carcinoma [PDF]
Acta Dermato-VenereologicaATP citrate lyase, the first rate-limiting enzyme in de novo lipogenesis, plays a crucial role in tumour progression. This study explores ATP citrate lyase’s potential as a tumour biomarker and its role in cutaneous squamous cell carcinoma.
Ruiting Luo +6 more
doaj +2 more sources
Exploring the Role of ATP-Citrate Lyase in the Immune System [PDF]
Frontiers in Immunology, 2021 Studies over the past decade have revealed that metabolism profoundly influences immune responses. In particular, metabolism causes epigenetic regulation of gene expression, as a growing number of metabolic intermediates are substrates for histone post ...
Monica Dominguez +5 more
doaj +2 more sources
A novel direct homogeneous assay for ATP citrate lyase[S] [PDF]
Journal of Lipid Research, 2009 ATP citrate lyase (ACL) is a cytosolic enzyme that catalyzes the synthesis of acetyl-CoA and oxaloacetate using citrate, CoA, and ATP as substrates and Mg2+ as a necessary cofactor.
Zhengping Ma +2 more
doaj +3 more sources
Impact of ATP-citrate lyase catalytic activity and serine 455 phosphorylation on histone acetylation and inflammatory responses in human monocytic THP-1 cells [PDF]
Frontiers in Immunology, 2022 ATP-citrate lyase (ACLY) is a key enzyme provoking metabolic and epigenetic gene regulation. Molecularly, these functions are exerted by the provision of acetyl-coenzyme A, which is then used as a substrate for de novo lipogenesis or as an acetyl-group ...
Monica Dominguez +7 more
doaj +2 more sources