Results 21 to 30 of about 29,839 (226)

ATP-citrate lyase is essential for macrophage inflammatory response

Biochemical and Biophysical Research Communications, 2013
Growing evidence suggests that energy metabolism and inflammation are closely linked and that cross-talk between these processes is fundamental to the pathogenesis of many human diseases. However, the molecular mechanisms underlying these observations are still poorly understood. Here we describe the key role of ATP-citrate lyase (ACLY) in inflammation.
Infantino V., Iacobazzi V., Palmieri F., Menga A.   +3 more
openaire   +6 more sources

Publisher Correction: ATP-citrate lyase promotes axonal transport across species [PDF]

Nature Communications, 2021
Aviel Even, Giovanni Morelli, Silvia Turchetto, Michal Shilian, Romain Le Bail, Sophie Laguesse, Nathalie Krusy, Ariel Brisker, Alexander Brandis, Shani Inbar, Alain Chariot, Frédéric Saudou, Paula Dietrich, Ioannis Dragatsis, Bert Brone, Loïc Broix, Jean-Michel Rigo, Miguel Weil, Laurent Nguyen   +18 more
doaj   +2 more sources

From meadows to milk to mucosa – adaptation of Streptococcus and Lactococcus species to their nutritional environments [PDF]

, 2012
Lactic acid bacteria (LAB) are indigenous to food-related habitats as well as associated with the mucosal surfaces of animals. The LAB family Streptococcaceae consists of the genera Lactococcus and Streptococcus.
Kok, Jan,, Kuipers, Oscar P.,, Price, Claire E.,, Zeyniyev, Araz,   +3 more
core   +13 more sources

Citrate-Mediated Acyl-CoA Synthesis Is Required for the Promotion of Growth and Triacylglycerol Production in Oleaginous Yeast Lipomyces starkeyi

Microorganisms, 2021
The oleaginous yeast Lipomyces starkeyi is an excellent producer of triacylglycerol (TAG) as a feedstock for biodiesel production. To understand the regulation of TAG synthesis, we attempted to isolate mutants with decreased lipid productivity and ...
Rikako Sato, Satoshi Ara, Harutake Yamazaki, Koji Ishiya, Sachiyo Aburatani, Hiroaki Takaku   +5 more
doaj   +1 more source

Corrigendum: Impact of ATP-citrate lyase catalytic activity and serine 455 phosphorylation on histone acetylation and inflammatory responses in human monocytic THP-1 cells [PDF]

Frontiers in Immunology
Monica Dominguez, Verena Truemper, Ana Carolina Mota, Bernhard Brüne, Bernhard Brüne, Bernhard Brüne, Bernhard Brüne, Dmitry Namgaladze   +7 more
doaj   +2 more sources

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism

Hepatology, EarlyView., 2022
Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Baugé, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloïse Woitrain, Niels J. Kloosterhuis, Eléonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberlé, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean‐Francois Goossens, Violeta Raverdy, Bruno Derudas, Jan Albert Kuivenhoven, Mikaël Croyal, Bart van de Sluis, Sven Francque, François Pattou, Patrick C. N. Rensen, Bart Staels, Joel T. Haas   +30 more
wiley   +1 more source

Selective autophagic degradation of ACLY (ATP citrate lyase) maintains citrate homeostasis and promotes oocyte maturation. [PDF]

Autophagy, 2023
He H, Wang J, Mou X, Liu X, Li Q, Zhong M, Luo B, Yu Z, Zhang J, Xu T, Dou C, Wu D, Qing W, Wu L, Zhou K, Fan Z, Wang T, Hu T, Zhang X, Zhou J, Miao YL.   +20 more
europepmc   +2 more sources

Regulation of ATP-citrate lyase gene transcription [PDF]

Yonsei Medical Journal, 1996
It has been suggested that glucose metabolites and insulin are the most important factors inducing ATP-citrate lyase (ACL) by a high carbohydrate diet. We have used a primary culture of rat hepatocytes to confirm the role of glucose and insulin in terms of ACL gene expression.
K S, Kim, J G, Kang, Y A, Moon, S W, Park, Y S, Kim   +4 more
openaire   +3 more sources

ATP-Citrate Lyase Deficiency in the Mouse [PDF]

Journal of Biological Chemistry, 2004
ATP-citrate lyase (Acly) is one of two cytosolic enzymes that synthesize acetyl-coenzyme A (CoA). Because acetyl-CoA is an essential building block for cholesterol and triglycerides, Acly has been considered a therapeutic target for hyperlipidemias and obesity.
Anne P, Beigneux, Cynthia, Kosinski, Bryant, Gavino, Jay D, Horton, William C, Skarnes, Stephen G, Young   +5 more
openaire   +2 more sources

The Drosophila Citrate Lyase Is Required for Cell Division during Spermatogenesis [PDF]

, 2020
The Drosophila melanogaster DmATPCL gene encodes for the human ATP Citrate Lyase (ACL) ortholog, a metabolic enzyme that from citrate generates glucose-derived Acetyl-CoA, which fuels central biochemical reactions such as the synthesis of fatty acids ...
Bucciarelli, Elisabetta, Cenci, Giovanni, Cipressa, Francesca, Di Giorgio, Maria Laura, Manzi, Diana, Morciano, Patrizia, Porrazzo, Antonella, Rong, Yikang S, Saraniero, Sara   +8 more
core   +1 more source