Results 121 to 130 of about 29,839 (226)
Perspectives for Advancing Biotechnological Succinic Acid Production
Microbial Biotechnology, Volume 19, Issue 5, May 2026.Succinic acid is an important molecule for sustainable chemical manufacturing, but its industrial production faces high costs and sustainability challenges, which are linked to feedstocks and excessive acid/base consumption. This opinion explores production routes based on next‐generation feedstocks and low‐pH fermentations to inspire novel cost ...
Christoph Gunkel, Bastian Blombach
wiley +1 more source
Genetics Selection Evolution, 2008 ATP-citrate lyase (ACL), one of the lipogenic enzymes, catalyses the formation of acetyl-coenzyme A (CoA) involved in the synthesis of fatty acid and cholesterol. In pig, very little is known about the ACL gene.
Xiong Yuan-Zhua +11 more
doaj +1 more source
Label-free shotgun proteomics and metabolite analysis reveal a significant metabolic shift during citrus fruit development. [PDF]
, 2011 Label-free LC-MS/MS-based shot-gun proteomics was used to quantify the differential protein synthesis and metabolite profiling in order to assess metabolic changes during the development of citrus fruits.
Blumwald, Eduardo +8 more
core +3 more sources
Journal of Diabetes, Volume 18, Issue 5, May 2026.This review highlights mitochondrial dysfunction as a central driver of pancreatic β cell failure in diabetes, caused by disrupted mitochondrial quality control (MQC), oxidative stress, and impaired organelle communication. Emerging therapies, such as DRAK2 inhibitors and metabolic reprogramming agents, show promise in restoring β cell function by ...
Ruihan Li +5 more
wiley +1 more source
New Insights into Behçet’s Syndrome Metabolic Reprogramming: Citrate Pathway Dysregulation
Mediators of Inflammation, 2018 To date, a major research effort on Behçet’s syndrome (BS) has been concentrated on immunological aspects. Little is known about the metabolic reprogramming in BS.
Anna Santarsiero +7 more
doaj +1 more source
Comparative biochemistry of CO2 fixation and the evolution of autotrophy [PDF]
, 2010 Carbon dioxide fixation is a polyphyletic trait that has evolved in widely separated prokaryotic branches. The three principal CO2-assimilation pathways are (i) the reductive pentose-phosphate cycle, i. e.
Ana María Velasco +3 more
core +2 more sources
Acta Physiologica, Volume 242, Issue 5, May 2026.ABSTRACT Background Abnormal accumulation of lipids within the kidney contributes to the progression of chronic kidney disease, but the underlying metabolic mechanisms remain unclear. Citrate is a central metabolite in cellular energy regulation and is frequently elevated in advanced kidney disease, yet its impact on renal lipid metabolism has not been
Marta Sanz‐Gómez +8 more
wiley +1 more source
Molecular OncologyIn pancreatic ductal adenocarcinoma (PDAC), metabolic rewiring and resistance to standard therapy are closely associated. PDAC cells show enormous requirements for glucose‐derived citrate, the first rate‐limiting metabolite in the synthesis of new lipids.
Aiora Cenigaonandia‐Campillo +16 more
doaj +1 more source
Plant Biotechnology Journal, Volume 24, Issue 5, Page 2956-2969, May 2026.ABSTRACT Base excision repair (BER) is a critical pathway for repairing damaged DNA bases in cells; however, the mechanisms of protein recruitment and interaction in this pathway remain largely unexplored in higher plants. In this study, we used ‘84K’ poplar (Populus alba × P.
Aoyu Ling +8 more
wiley +1 more source
European Journal of Organic Chemistry, Volume 29, Issue 16, 25 April 2026.A chemoenzymatic synthesis of (1R,2S)‐metaraminol was developed by combining gold(I)‐catalysed alkyne hydration and stereoselective biotransamination in a sequential one‐pot process. Various phenol protection strategies were considered in oxidation‐reduction sequences, providing access to enantiopure propargylic alcohols as starting materials for ...
Lorena Escot +2 more
wiley +1 more source