Results 41 to 50 of about 30,215 (258)
Radicicol Binds and Inhibits Mammalian ATP Citrate Lyase [PDF]
Journal of Biological Chemistry, 2000 Six different biotinylated radicicol derivatives were synthesized as affinity probes for identification of cellular radicicol-binding proteins. Derivatives biotinylated at the C-17 (BR-1) and C-11 (BR-6) positions retained the activity of morphological reversion in v-src-transformed 3Y1 fibroblasts.
S W, Ki +5 more
openaire +2 more sources
ATP citrate lyase is increased in human breast cancer, depletion of which promotes apoptosis
Tumor Biology, 2017 Breast cancer is a malignant tumor that is harmful to women’s health around the world. Investigating the biological mechanism is, therefore, of pivotal importance to improve patients’ prognoses.
Diyu Wang +4 more
doaj +1 more source
PLoS ONE, 2020 Mycobacterium tuberculosis is the causative agent of tuberculosis and has evolved an ability to survive in hostile host environments. M. tuberculosis is thought to utilize the rTCA cycle to sustain its latent growth during infection, but the enzymatic ...
Jialing Hu +3 more
doaj +1 more source
Whole-genome sequence analysis of Bombella intestini LMG 28161T, a novel acetic acid bacterium isolated from the crop of a red-tailed bumble bee, Bombus lapidarius [PDF]
, 2016 The whole-genome sequence of Bombella intestini LMG 28161(T), an endosymbiotic acetic acid bacterium (AAB) occurring in bumble bees, was determined to investigate the molecular mechanisms underlying its metabolic capabilities.
Borremans, Wim +7 more
core +8 more sources
Cell Reports, 2019 Summary: Sugars and refined carbohydrates are major components of the modern diet. ATP-citrate lyase (ACLY) is upregulated in adipocytes in response to carbohydrate consumption and generates acetyl-coenzyme A (CoA) for both lipid synthesis and ...
Sully Fernandez +11 more
doaj +1 more source
Extracellular Citrate Is a Trojan Horse for Cancer Cells
Frontiers in Molecular Biosciences, 2020 The first intermediate in the mitochondrial tricarboxylic acid (TCA) cycle is citrate, which is essential and acts as a metabolic regulator for glycolysis, TCA cycle, gluconeogenesis, and fatty acid synthesis.
Agata Petillo +4 more
doaj +1 more source
eLife, 2021 Inducible regulatory T (iTreg) cells play a central role in immune suppression. As iTreg cells are differentiated from activated T (Th0) cells, cell metabolism undergoes dramatic changes, including a shift from fatty acid synthesis (FAS) to fatty acid ...
Miaomiao Tian +15 more
doaj +1 more source
BCKDH: the missing link in apicomplexan mitochondrial metabolism is required for full virulence of Toxoplasma gondii and Plasmodium berghei [PDF]
, 2014 While the apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii are thought to primarily depend on glycolysis for ATP synthesis, recent studies have shown that they can fully catabolize glucose in a canonical TCA cycle.
Barrett, Michael P. +11 more
core +1 more source
Stereochemistry of si‐Citrate Synthase and ATP‐Citrate‐Lyase Reactions [PDF]
European Journal of Biochemistry, 1971 A new synthesis of R‐ and S‐acetic acid (R‐ and S‐[2H1, 3H1]acetate) is described. R‐Acetic acid after conversion into citrate on si‐citrate synthase and cleavage of the citrate with citrate lyase regenerates an acetate which is still predominantly R.
H, Lenz +8 more
openaire +2 more sources
Journal of Lipid Research, 2003 Hamsters were fed a control diet or diets containing palm, olive, safflower, or fish oil for 2 weeks. In villus cell populations from duodenum, jejunum, and ileum, rates of intestinal fatty acid and cholesterol synthesis were estimated, as were sterol ...
F. Jeffrey Field +2 more
doaj +1 more source