Structural basis for histone H3 acetylation by Rtt109 in complex with histone chaperones Asf1 and Vps75 [PDF]
, 2020 In eukaryotes, genetic material is stored as chromatin, a DNA-protein complex whose structure is tightly regulated. Histones are the main protein components of chromatin and their post-translational modifications (PTMs) influence several cellular ...
Danilenko, Nataliya
core +1 more source
Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion [PDF]
, 2017 Glucagon plays a major role in the regulation of glucose homeostasis during fed and fasting states. However, the mechanisms responsible for the regulation of pancreatic α cell mass and function are not completely understood.
Alvin C. Powers +17 more
core +1 more source
The Origin and Early Evolution of Life [PDF]
, 2022 What is life? How, where, and when did life arise? These questions have remained most fascinating over the last hundred years. Systems chemistry is the way to go to better understand this problem and to try and answer the unsolved question regarding the ...
core +1 more source
Mycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds [PDF]
, 2015 Tuberculosis (TB) remains a worldwide problem and the need for new drugs is increasingly more urgent with the emergence of multidrug- and extensively-drug resistant TB.
Aldrich, Courtney +13 more
core +1 more source
The Bioinorganic Periodic Table [PDF]
, 2019 Life depends on metals. While carbon, in terms of abundance and versatility, is considered THE element of life, the vast variety and diversity of the chemistry taking place in living organisms could not be achieved without metal ions.
Freisinger, Eva, Sigel, Roland K O
core +2 more sources
Effects of disulfiram on the metabolome of MRSA [PDF]
, 2023 Disulfiram, known as Antabuse®, is an oral drug for the treatment of alcohol dependence. Previous studies have indicated that disulfiram (DSF) exhibits antibacterial effects, particularly against Gram-positive bacteria, such as methicillin-resistant ...
Naidu, Surya Teja
core +1 more source
Mammalian Dihydropyrimidine Dehydrogenase: Employing Transient State Kinetic Methods to Determine Catalytic and Inhibitory Mechanisms [PDF]
, 2023 Dihydropyrimidine dehydrogenase (DPD) catalyzes the two-electron reduction of pyrimidine bases uracil and thymine as the first step in pyrimidine catabolism. The enzyme achieves this simple chemistry using a complex cofactor set including two flavins and
Forouzesh, Dariush
core +1 more source
Strukturelle und biochemische Untersuchungen der späten Enzyme der (Bacterio)chlorophyll a-Biosynthese [PDF]
, 2016 During (bacterio)chlorophyll biosynthesis, the enzyme DPOR catalyzes the stereospecific two-electron reduction of the tetrapyrrole D ring in an ATP-dependent manner.
Lange, Christiane
core +1 more source
The effect of diet and sodium bicarbonate ingestion upon acid-base balance and performance capacity [PDF]
, 1979 Thesis (M.A.)--Michigan State University. Department of Health, Physical Education and Recreation, 1979Includes bibliographical references (pages 81 ...
Fallah-Bosjin, Shokr
core +2 more sources
Design and SAR Analysis of Covalent Inhibitors Driven by Hybrid QM/MM Simulations [PDF]
, 2020 Quantum mechanics/molecular mechanics (QM/MM) hybrid technique is emerging as a reliable computational method to investigate and characterize chemical reactions occurring in enzymes.
Callegari D. +4 more
core +1 more source