Zika Virus Reprograms Microglial Mitochondrial Metabolism to Support Immune Activation and Viral Replication: Omega-3 DHA Counteracts Neuroinflammation and Viral Persistence. [PDF]
Mol NeurobiolBraz-de-Melo HA +20 more
europepmc +1 more source
Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis
Advanced Science, EarlyView.This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu +15 more
wiley +1 more source
Targeting mitochondrial transporters and metabolic reprogramming for disease treatment. [PDF]
J Transl MedAnselme M, He H, Lai C, Luo W, Zhong S.
europepmc +1 more source
Disulfiram/Copper Combination as a Potential Therapeutic Approach for Hepatocellular Carcinoma: Targeting the ATF3-Mitochondrial Cell Death Pathway. [PDF]
J CancerCao J +7 more
europepmc +1 more source
Bioactive metal-protein matrix for promoting MRSA infection wound therapy through bioenergy-induced angiogenesis. [PDF]
TheranosticsLi S +6 more
europepmc +1 more source
Mitochondria as a Disease-Relevant Organelle in Rheumatoid Arthritis: A Key Breakout in Fight Against the Disease. [PDF]
BiomedicinesIaconis A +3 more
europepmc +1 more source
Ubiquitin-specific protease 26 facilitates endochondral ossification by driving chondrocyte hypertrophy and mineralization. [PDF]
Bone ResLi C +8 more
europepmc +1 more source