Results 211 to 220 of about 30,539 (256)

Parthenolide attenuated the endometriosis-like lesions by activating autophagy and suppressing NLRP3 inflammasome activity. [PDF]

Iran J Basic Med Sci
Jin L, Fu T, Chi C, Zhou J, Lin J, Hou W.   +5 more
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Abstract 150: Targeting The Lipogenic Enzyme ATP Citrate Lyase As A Potential Therapy Against Coronary Artery Disease

Arteriosclerosis, Thrombosis and Vascular Biology, 2023
Introduction: Coronary artery disease (CAD) such as coronary stenosis and intra vein graft stenosis are characterized by a cancer-like pro-proliferative and apoptosis-resistant phenotype of smooth muscle cells (SMCs), fueled by a metabolic shift ...
Y. Grobs, S. Lemay, C. Romanet, A. Bourgeois, Mabrouka Salem, S. Martineau, S. Breuils-Bonnet, Pierre Voisine, F. Potus, S. Provencher, O. Boucherat, S. Bonnet   +11 more
semanticscholar   +1 more source

Abstract 13184: ATP Citrate Lyase a New Therapeutic Target for Vascular Remodeling Diseases

Circulation, 2021
Vascular remodeling diseases (VRD) like coronary artery diseases or in-stent restenosis are characterized by proliferative and apoptosis-resistant vascular smooth muscle cells (VSMCs).
Y. Grobs, S. Lemay, C. Romanet, Sandra Breuils Bonnet, M. Orcholski, A. Bourgeois, M. Sauvaget, K. Shimauchi, P. Voisine, R. Paulin, F. Potus, S. Provencher, O. Boucherat, S. Bonnet   +13 more
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Abstract 10759: Atp Citrate Lyase: An Attractive Target at the Nexus of Metabolic and Epigenetic Alterations in Pulmonary Arterial Hypertension

Circulation, 2021
Introduction: Pulmonary arterial hypertension (PAH) is characterized by progressive obliteration of distal pulmonary arteries (PAs). As in cancer, excessive proliferation and resistance to apoptosis of PA resident cells (especially PA smooth muscle ...
C. Romanet, A. Bourgeois, Y. Grobs, Tsukasa Shimauchi, S. Lemay, V. Nadeau, Sandra Breuils Bonnet, S. Provencher, O. Boucherat, S. Bonnet   +9 more
semanticscholar   +1 more source

Uropathogenic Escherichia coli virulence factor α hemolysin reduces histone acetylation to inhibit expression of pro-inflammatory cytokine genes.

Journal of Infectious Diseases, 2021
Urinary tract infections are common and costly diseases affecting millions of people. Uropathogenic Escherichia coli (UPEC) is a primary cause of these infections and has developed multiple strategies to avoid the host immune response. Here, we dissected
Zhengguo Zhang, Ming Wang, Yu Zhang, Yiming Zhang, Marek Bartkuhn, M. Markmann, H. Hossain, T. Chakraborty, S. Hake, Zhankui Jia, A. Meinhardt, S. Bhushan   +11 more
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Abstract 15608: Atp Citrate Lyase a New Signaling Hub Between Metabolism and Epigenetic in Vascular Remodeling and Right Ventricle Failure in Pulmonary Arterial Hypertension

, 2020
Objective: Pulmonary arterial hypertension (PAH) is a lung disease characterized by vascular lesions and obstruction of distal pulmonary arteries (PA) leading to right ventricle (RV) remodeling and death.
C. Romanet, A. Bourgeois, Y. Grobs, S. Bonnet, V. Nadeau, S. Provencher, O. Boucherat, S. Bonnet   +7 more
semanticscholar   +1 more source

Two-stage fermentation enhanced single-cell protein production by Yarrowia lipolytica from food waste.

Bioresource Technology, 2022
The resource utilization of food waste is crucial, and single-cell protein (SCP) is attracting much attention due to its high value. This study aimed to convert food waste to SCP by Yarrowia lipolytica.
Rui Yang, Zheng Chen, Peng Hu, Shicheng Zhang, G. Luo   +4 more
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ATP citrate lyase (ACLY) regulates pro-inflammatory phenotypes in regulatory T cells in response to oxidized phospholipids 3848

Journal of Immunology
Regulatory T cells (Tregs) protect against atherosclerosis but lose stability and function as the disease progresses. Our lab has recently identified that the oxidized phospholipid oxPAPC (oxidized 1-palmitoyl-2- arachidonoyl-sn-glycero-3 ...
Meghan K. Graber, Sharareh Ameli, Brenna D. Appleton, J.C. Rathmell, Amy S. Major   +4 more
semanticscholar   +1 more source

ATP citrate lyase drives vascular remodeling in systemic and pulmonary vascular diseases through metabolic and epigenetic changes.

Science Translational Medicine
ATP citrate lyase (ACLY), a crucial enzyme in de novo lipid synthesis and histone acetylation, plays a key role in regulating vascular smooth muscle cell (VSMC) proliferation and survival.
Y. Grobs, C. Romanet, S. Lemay, A. Bourgeois, Pierre Voisine, Charlie Théberge, M. Sauvaget, S. Breuils-Bonnet, S. Martineau, Reem El Kabbout, C. Valasarajan, P. Chelladurai, A. Pelletier, M. Mougin, É. Dumais, Jean Perron, N. Flamand, F. Potus, S. Provencher, S. Pullamsetti, O. Boucherat, S. Bonnet   +21 more
semanticscholar   +1 more source