Results 221 to 230 of about 30,539 (256)

Abstract 4136511: Targeting ATP Citrate Lyase: A Novel Therapeutic Strategy for Vascular Remodeling in Pulmonary Hypertension

Circulation
Introduction: Pulmonary arterial hypertension (PAH) is a vascular remodeling disease characterized by a progressive obliteration of distal pulmonary arteries (PA), which is driven by a cancer-like pro-proliferative phenotype of smooth muscle cells ...
Y. Grobs, C. Romanet, S. Lemay, A. Bourgeois, Pierre Voisine, Charlie Théberge, M. Sauvaget, Sandra Breuils Bonnet, S. Martineau, EL-Kabbout Reem, A. Pelletier, M. Mougin, É. Dumais, Jean Perron, N. Flamand, F. Potus, S. Provencher, O. Boucherat, S. Bonnet   +18 more
semanticscholar   +1 more source

Emerging roles of ATP citrate lyase in kidney diseases: from pathogenic driver to therapeutic target

Renal Failure
ATP-citrate lyase (ACLY) is a crucial cytosolic and nuclear enzyme that catalyzes the synthesis of acetyl-CoA from citrate, serving as a central metabolic node linking carbohydrate metabolism to de novo lipogenesis and histone acetylation.
Mengjiao Wei, Mina Tao, Huifang Tan, Zhiyuan Jin, Yiya Yang, Zheng Xiao, Guoli Li, Yinyin Chen   +7 more
semanticscholar   +1 more source

Citrate metabolism controls the senescent microenvironment via the remodeling of pro-inflammatory enhancers.

Cell Reports
The senescent microenvironment and aged cells per se contribute to tissue remodeling, chronic inflammation, and age-associated dysfunction. However, the metabolic and epigenomic bases of the senescence-associated secretory phenotype (SASP) remain largely
Kan Etoh, Hirotaka Araki, Tomoaki Koga, Yuko Hino, Kanji Kuribayashi, Shinjiro Hino, M. Nakao   +6 more
semanticscholar   +1 more source

Investigation of Analytical Methods for the Estimation of Rosuvastatin and Bempedoic acid in Pharmaceutical Formulation and Human Plasma: A Review

Research Journal of Pharmacy and Technology
Cardiovascular disorders are most common in today’s era. One of the most important causes of cardiovascular diseases is hypercholesterolemia. In recent years develop a new and novel combination drug for the treatment of hypercholesterolemia has ...
Aswathy Sr, Hemnath Elango, A. V., Arsha Surendran   +3 more
semanticscholar   +1 more source

ACLY‐Driven Metabolic Reprogramming Promotes Histone Acetylation and Inflammation‐Associated Fibrosis in Chronic Kidney Disease

Advancement of science
The mechanisms by which metabolic stress drives epigenetic dysregulation and fibrosis in chronic kidney disease (CKD) remain incompletely understood.
Chunxiu Du, Dhanunjay Mukhi, Lingzhi Li, Chenyu Li, Siyu Pan, Bernhard Dumoulin, Eunji Ha, Lakshmi P Kolligundla, Yanjuan Hou, Jonathan Levinsohn, Chaelin Kang, Konstantin A. Klötzer, Junnan Wu, Samer Mohandes, K. Wellen, Katalin Susztak   +15 more
semanticscholar   +1 more source

Abstract 103: Acly Inhibition As A Novel Therapeutic Approach For Vascular Remodeling In Coronary Artery Disease

Arteriosclerosis, Thrombosis and Vascular Biology
Coronary artery (CoA) disease (CAD) is characterized by neointimal hyperplasia (NH), which is driven by a cancer-like pro-proliferative phenotype of smooth muscle cells (SMCs).
Y. Grobs, C. Romanet, S. Lemay, A. Bourgeois, Charlie Théberge, M. Sauvaget, S. Breuils-Bonnet, S. Martineau, Reem El Kabbout, F. Potus, Pierre Voisine, S. Provencher, O. Boucherat, S. Bonnet   +13 more
semanticscholar   +1 more source

Properties and organ distribution of ATP citrate (pro-3S)-lyase.

Biochimica et Biophysica Acta, 1980
G. Hoffmann, H. Andres, L. Weiss, C. Kreisel, R. Sander   +4 more
semanticscholar   +1 more source

ATP citrate (pro-3S)-lyase in the rat; two-step purification procedure, properties, organ distribution.

Hoppe-Seyler´s Zeitschrift für physiologische Chemie, 1979
G. Hoffmann, J. Schiessl, L. Weiss
semanticscholar   +1 more source

Pyruvate dehydrogenase and ATP citrate (pro-3S)-lyase activities in adipose tissue and liver of the young lean and the older obese rat.

Hoppe-Seyler´s Zeitschrift für physiologische Chemie, 1979
G. Hoffmann, C. Kreisel, O. Wieland, L. Weiss   +3 more
semanticscholar   +1 more source

ATP citrate (pro-3S)-lyase

, 1990
Dietmar Schomburg, Margit Salzmann
semanticscholar   +1 more source