Results 171 to 180 of about 345,136 (302)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Cellular signaling pathway of Shiga toxin-induced ATP release. [PDF]

Front Cell Infect Microbiol
Johansson K, Arvidsson I, Wendler M, Kristoffersson AC, Karpman D.   +4 more
europepmc   +1 more source

Increased ATP Release and Higher Impact of Adenosine A_2A Receptors on Corticostriatal Plasticity in a Rat Model of Presymptomatic Parkinson's Disease. [PDF]

Mol Neurobiol, 2023
Gonçalves FQ, Matheus FC, Silva HB, Real JI, Rial D, Rodrigues RJ, Oses JP, Silva AC, Gonçalves N, Prediger RD, Tomé ÂR, Cunha RA.   +11 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Activation of TRPV3 channels in bladder cancer cells stimulates ATP release. [PDF]

Mol Pharmacol
Janenz J, Leipe A, Urban N, Schaefer M, Hill K.   +4 more
europepmc   +1 more source

Propidium uptake and ATP release in A549 cells share similar transport mechanisms. [PDF]

Biophys J, 2022
Boudreault F, Tan JJ, Grygorczyk R.
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Increased Synaptic ATP Release and CD73-Mediated Formation of Extracellular Adenosine in the Control of Behavioral and Electrophysiological Modifications Caused by Chronic Stress. [PDF]

ACS Chem Neurosci, 2023
Dias L, Pochmann D, Lemos C, Silva HB, Real JI, Gonçalves FQ, Rial D, Gonçalves N, Simões AP, Ferreira SG, Agostinho P, Cunha RA, Tomé AR.   +12 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Connexins 43 and 45 hemichannels mediate ATP release in the urinary bladder. [PDF]

Bladder (San Franc)
Sana-Ur-Rehman H, Markus I, Moalem-Taylor G, Moore KH, Mansfield KJ, Liu L.   +5 more
europepmc   +1 more source