Results 191 to 200 of about 345,136 (302)

A 3D-printed, multi-modal microfluidic device for measuring nitric oxide and ATP release from flowing red blood cells. [PDF]

Anal Methods, 2022
Hayter EA, Azibere S, Skrajewski LA, Soule LD, Spence DM, Martin RS.   +5 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

ACPA-Induced ATP release and K⁺ efflux trigger NLRP3 inflammasome activation in rheumatoid arthritis. [PDF]

Cell Commun Signal
Cai L, Zhang K, Gao J, Xiao B, Li M, Meng X, Chen Z, Chen X, Chen S, Li J.   +9 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

VNUT-mediated ATP release suppresses T helper 1 (T_H1) cell differentiation via the P2X7R-JNK-FOXO3a-Eomes signaling cascade. [PDF]

Sci Adv
Wu B, Sheng L, Feng Z, Wang X, Chen L.
europepmc   +1 more source

Connexin30-Deficiency Causes Mild Hearing Loss With the Reduction of Endocochlear Potential and ATP Release. [PDF]

Front Cell Neurosci, 2021
Chen J, Chen P, He B, Gong T, Li Y, Zhang J, Lv J, Mammano F, Hou S, Yang J.   +9 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

ATP, calcium uptake and growth hormone release [PDF]

FEBS Letters, 1971
Schofield, J.G., Stead, Margaret
openaire   +2 more sources

Role of Pannexin 1, P2X7, and CFTR in ATP Release and Autocrine Signaling by Principal Cells of the Epididymis. [PDF]

Function (Oxf)
Brochu K, Minas A, Berloffa Belardin L, Légaré C, Breton S.   +4 more
europepmc   +1 more source

An introduction to the special issue "The contribution of pannexin-1, connexins and CALHM ATP-release channels to purinergic signalling". [PDF]

Purinergic Signal, 2021
Kennedy C.
europepmc   +1 more source