Results 211 to 220 of about 332,141 (261)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Mechanisms of ATP Release by Inflammatory Cells [PDF]
International Journal of Molecular Sciences, 2018 Extracellular nucleotides (e.g., ATP, ADP, UTP, UDP) released by inflammatory cells interact with specific purinergic P2 type receptors to modulate their recruitment and activation. The focus of this review is on stimuli and mechanisms of extracellular nucleotide release and its consequences during inflammation.
Fadi Jebbawi +2 more
exaly +4 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Purinergic Signalling: ATP Release
Neurochemical Research, 2001Adenosine triphosphate (ATP) has a fundamental intracellular role as the universal source of energy for all living cells. The demonstration of its release into the extracellular space and the identification and localisation of specific receptors on target cells have been essential in establishing, after considerable resistance, its extracellular ...
P, Bodin, G, Burnstock
openaire +2 more sources
ATP-Stimulated Release of ATP by Human Endothelial Cells
Journal of Cardiovascular Pharmacology, 1996We investigated the effects of several concentrations of extracellular ATP on the release of intracellular ATP by human umbilical vein endothelial cells (HUVEC) in primary cultures. When ATP is added to the medium of cultured EC at a concentration of 1 microM, it is readily degraded by extracellular enzymes; 10 microM ATP added to the culture medium ...
P, Bodin, G, Burnstock
openaire +2 more sources
Neural Release of ATP and Adenosinea
Annals of the New York Academy of Sciences, 1990Release of ATP can be evoked from noradrenergic nerve varicosities isolated from guinea pig ileal myenteric plexus by depolarization with K+ and veratridine and during exposure to acetylcholine or 5-HT. Clonidine, however, modulates the release of [3H]noradrenaline without affecting the release of ATP.
T D, White, W F, MacDonald
openaire +2 more sources
Vesicular release of ATP at central synapses
Pflügers Archiv - European Journal of Physiology, 2006Adenosine triphosphate (ATP) acts as a fast excitatory transmitter in several regions of the central nervous system (CNS) including the medial habenula, dorsal horn, locus coeruleus, hippocampus, and somatosensory cortex. Postsynaptic actions of ATP are mediated through an extended family of P2X receptors, widely expressed throughout the CNS.
Pankratov, Yuri +3 more
openaire +3 more sources
Retrograde Inhibition of Transmitter Release by ATP
Journal of Neurochemistry, 1980Abstract: After labelling ACh tissue stores in Torpedo electric organ prisms with radioactive acetate, the release of ACh and ATP triggered by electrical stimulation or KCI depolarization was measured in the same perfusate samples. The luciferin‐luciferase reaction for ATP was first counted, then the radioactive content of the sample determined ...
M, Israël +4 more
openaire +2 more sources
2012
For all its complexity, the brain can be broadly divided into two major types of cells, neurons and glial cells. Glia are defined as nonneuronal cells and function to maintain homeostasis, form myelin, and provide support and protection for neurons. Formerly thought to be passive support cells, we now know that astrocytes, the major subtype of glial ...
Dustin J. Hines, Philip G. Haydon
openaire +1 more source
For all its complexity, the brain can be broadly divided into two major types of cells, neurons and glial cells. Glia are defined as nonneuronal cells and function to maintain homeostasis, form myelin, and provide support and protection for neurons. Formerly thought to be passive support cells, we now know that astrocytes, the major subtype of glial ...
Dustin J. Hines, Philip G. Haydon
openaire +1 more source
Clodronate: A Vesicular ATP Release Blocker
Trends in Pharmacological Sciences, 2018Clodronate is a first-generation bisphosphonate used worldwide for antiresorptive therapy for osteoporosis. Although clodronate is analgesic in nature, its mechanism and efficacy were unknown for some time. Recently, clodronate was identified as a selective and potent inhibitor for vesicular nucleotide transporter (VNUT), a transporter responsible for ...
Yoshinori, Moriyama, Masatoshi, Nomura
openaire +2 more sources
Characteristics of neuronal release of ATP
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 1984Recent studies have described a transmitter-like release of ATP in brain. Once released, extraneuronal ATP is rapidly metabolized to adenosine by ecto-ATPase and nucleotidase. Adenosine, through actions at specific receptors, inhibits neuronal firing in the brain.
openaire +2 more sources