Results 61 to 70 of about 345,136 (302)

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

Drug Effect Unveils Inter-head Cooperativity and Strain-dependent ADP Release in Fast Skeletal Actomyosin [PDF]

, 2009
Amrinone is a bipyridine compound with characteristic effects on the force-velocity relationship of fast skeletal muscle, including a reduction in the maximum shortening velocity and increased maximum isometric force.
Torres, Nuria Albet,, Geeves, M., Barman, T., Barman, Tom, Bloemink, Marieke J, Schmitz, S, Piperio, C., Lionne, C, Albet-Torres, Nuria, Schmitz, Stephan, Bloemink, Marieke J., Golker, K., Bloemink, M., Candau, R., Veigel, C., Herrmann, Christian, Albet-Torres, N., Geeves, Michael A, Mansson, A., Mansson, Alf, Herrmann, C., Månsson, Alf,, Piperio, C, Candau, Robin, Geeves, Michael A., Herrmann, C, Frölander, Kerstin,, Schmitz, S., Candau, R, Piperio, Claudia, Lionne, Corinne, Veigel, Claudia, Bloemink, MJ, Geeves, MA, Frolander, K., Lionne, C., Golker, Kerstin, Frolander, Kerstin, Veigel, C, Golker, Kerstin,, Barman, T   +40 more
core   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Release of ATP from marginal cells in the cochlea of neonatal rats can be induced by changes in extracellular and intracellular ion concentrations. [PDF]

PLoS ONE, 2012
BackgroundAdenosine triphosphate (ATP) plays an important role in the cochlea. However, the source of ATP and the mechanism by which it is released remain unclear.
Yating Peng, Jie Chen, Shan He, Jun Yang, Hao Wu   +4 more
doaj   +1 more source

Supporting Survivor‐Centered Care Through Digital Health Integration

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Survivors of childhood cancer face barriers to receiving guideline‐based, long‐term follow‐up care. Two digital tools, Passport for Care (PFC) and Cancer SurvivorLink (SurvivorLink), address complementary gaps by enabling tailored survivorship care plan (SCP) generation, updating, storage, and sharing.
Jordan G. Marchak, Rebecca Williamson‐Lewis, Michael O'Connor, Michael Palgon, Yu‐Ra Kim, Michael Schuckenbrock, Paula Edwards, Abraham Mendoza, Anthony Adams, Brian Arriaga‐Solis, Justin Parker, Harry Tinoco‐Giraldo, Jason King, C. Michael Fordis, Karen E. Effinger, Maria Monica Gramatges   +15 more
wiley   +1 more source

ATP-Triggered Drug Release of Self-Assembled 3D DNA Nanostructures for Fluorescence Imaging and Tumor Therapy

, 2022
Stimulus-responsive materials are ideal carriers for precisely controlled drug delivery due to their high selectivity. However, the complex physiological environment hinders its development in clinical medicine.
Wenjing Zhao, Yao Jiang (1469614), Wenjing Zhao (318619), Huimin Zhou (383058), Huimin Zhou, Yao Jiang, Shusheng Zhang, Shusheng Zhang (1500898)   +7 more
core   +1 more source

Prevention of M2 polarization and temporal limitation of differentiation in monocytes by extracellular ATP

BMC Immunology, 2023
Background Elevated levels of extracellular adenosine triphosphate (ATP) modulate immunologic pathways and are considered to be a danger signal in inflammation, lung fibrosis and cancer.
Benedikt F. Scherr, Martin F. Reiner, Flavia Baumann, Kerstin Höhne, Tobias Müller, Korcan Ayata, Joachim Müller-Quernheim, Marco Idzko, Gernot Zissel   +8 more
doaj   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Multiple P2Y receptors couple to calcium-dependent, chloride channels in smooth muscle cells of the rat pulmonary artery [PDF]

, 2005
Uridine 5'-triphosphate (UTP) and uridine 5'-diphosphate (UDP) act via P2Y receptors to evoke contraction of rat pulmonary arteries, whilst adenosine 5'-triphosphate (ATP) acts via P2X and P2Y receptors.
Chootip, Krongkarn, Gurney Alison M, Gurney, Alison M.; id_orcid, Alison M Gurney, Kennedy, Charles, Krongkarn Chootip, Charles Kennedy, Gurney, Alison M., Chootip Krongkarn, Kennedy Charles   +9 more
core   +1 more source

Tollip Inhibits IL-33 Release and Inflammation in Influenza A Virus-Infected Mouse Airways

Journal of Innate Immunity, 2022
Respiratory influenza A virus (IAV) infection continues to pose significant challenges in healthcare of human diseases including asthma. IAV infection in mice was shown to increase IL-33, a key cytokine in driving airway inflammation in asthma, but how ...
Niccolette Schaunaman, Kris Genelyn Dimasuay, Diana Cervantes, Liwu Li, Mari Numata, Monica Kraft, Hong Wei Chu   +6 more
doaj   +1 more source