Renal epithelial cells can release ATP by vesicular fusion
Frontiers in Physiology, 2013 Renal epithelial cells have the ability to release nucleotides as paracrine factors. In the intercalated cells of the collecting duct, ATP is released by connexin30 (cx30), which is selectively expressed in this cell type.
Randi G Bjaelde +4 more
doaj +1 more source
Exocytotic Release of ATP from Cultured Astrocytes [PDF]
Journal of Biological Chemistry, 2007 Astrocytes appear to communicate with each other as well as with neurons via ATP. However, the mechanisms of ATP release are controversial. To explore whether stimuli that increase [Ca(2+)](i) also trigger vesicular ATP release from astrocytes, we labeled ATP-containing vesicles with the fluorescent dye quinacrine, which exhibited a significant co ...
PANGRSIC T +9 more
openaire +4 more sources
New platelet functional method for identification of pathogenic antibodies in HIT patients
Platelets, 2017 Heparin-induced thrombocytopenia (HIT) is a thrombotic complication of heparin therapy. The most used functional method for HIT diagnosis is serotonin release assay (SRA).
M. L. Guarino +6 more
doaj +1 more source
Urinary ATP as an indicator of infection and inflammation of the urinary tract in patients with lower urinary tract symptoms [PDF]
, 2015 BACKGROUND: Adenosine-5'-triphosphate (ATP) is a neurotransmitter and inflammatory cytokine implicated in the pathophysiology of lower urinary tract disease. ATP additionally reflects microbial biomass thus has potential as a surrogate marker of urinary
Baio, Gianluca +10 more
core +1 more source
Storage and Release of ATP from Astrocytes in Culture [PDF]
Journal of Biological Chemistry, 2003 ATP is released from astrocytes and is involved in the propagation of calcium waves among them. Neuronal ATP secretion is quantal and calcium-dependent, but it has been suggested that ATP release from astrocytes may not be vesicular. Here we report that, besides the described basal ATP release facilitated by exposure to calcium-free medium, astrocytes ...
Coco S +7 more
openaire +5 more sources
Biosensor measurement of purine release from cerebellar cultures and slices [PDF]
, 2010 We have previously described an action-potential and Ca2+-dependent form of adenosine release in the molecular layer of cerebellar slices. The most likely source of the adenosine is the parallel fibres, the axons of granule cells. Using microelectrode
Eason, Robert +5 more
core +1 more source
Altered ATP release and metabolism in dorsal root ganglia of neuropathic rats
Molecular Pain, 2008 Background Adenosine 5'-triphosphate (ATP) has a ubiquitous role in metabolism and a major role in pain responses after tissue injury. We investigated the changes in basal and KCl-evoked ATP release from rat dorsal root ganglia (DRG) after peripheral ...
Omoto Kevin S +8 more
doaj +1 more source
Ontogeny of purinergic receptor-regulated Ca2+ signaling in mouse cortical collecting duct epithelium [PDF]
, 2002 Changes in ATP-induced increase in {[}Ca2+], during collecting duct ontogeny were studied in primary monolayer cultures of mouse ureteric bud (UB) and cortical collecting duct (CCD) cells by Fura-PE3 fluorescence ratio imaging.
Tschop, J. +4 more
core +1 more source
Diacylglycerol Signaling Underlies Astrocytic ATP Release
Neural Plasticity, 2011 Astrocytes have the ability to modulate neuronal excitability and synaptic transmission by the release of gliotransmitters. The importance of ATP released downstream of the activation of Gq-coupled receptors has been well established, but the mechanisms ...
Alison E. Mungenast
doaj +1 more source
ATP Release from Human Airway Epithelial Cells Exposed to Staphylococcus aureus Alpha-Toxin
Toxins, 2016 Airway epithelial cells reduce cytosolic ATP content in response to treatment with S. aureus alpha-toxin (hemolysin A, Hla). This study was undertaken to investigate whether this is due to attenuated ATP generation or to release of ATP from the cytosol ...
Romina Baaske +6 more
doaj +1 more source