Sphingosine-1-Phosphate Induces ATP Release via Volume-Regulated Anion Channels in Breast Cell Lines
Life, 2021 High interstitial level of ATP and its lysate adenosine in the cancer microenvironment are considered a halo mark of cancer. Adenosine acts as a strong immune suppressor. However, the source of ATP release is unclear.
Kishio Furuya +3 more
doaj +1 more source
The dynamics of single spike-evoked adenosine release in the cerebellum [PDF]
, 2011 The purine adenosine is a potent neuromodulator in the brain, with roles in a number of diverse physiological and pathological processes. Modulators such as adenosine are difficult to study as once released they have a diffuse action (which can affect ...
Boris P. Klyuch +7 more
core +1 more source
A computational model of a microfluidic device to measure the dynamics of oxygen-dependent ATP release from erythrocytes. [PDF]
PLoS ONE, 2013 Erythrocytes are proposed to be involved in blood flow regulation through both shear- and oxygen-dependent mechanisms for the release of adenosine triphosphate (ATP), a potent vasodilator.
Richard J Sove +3 more
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Multiple P2Y receptors couple to calcium-dependent, chloride channels in smooth muscle cells of the rat pulmonary artery [PDF]
, 2005 Uridine 5'-triphosphate (UTP) and uridine 5'-diphosphate (UDP) act via P2Y receptors to evoke contraction of rat pulmonary arteries, whilst adenosine 5'-triphosphate (ATP) acts via P2X and P2Y receptors.
Chootip, Krongkarn +2 more
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Activity-dependent release of Adenosine: a critical re-evaluation of mechanism [PDF]
, 2008 Adenosine is perhaps the most important and universal modulator in the brain. The current consensus is that it is primarily produced in the extracellular space from the breakdown of previously released ATP.
Dale, Nicholas, Wall, Mark J.
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Sphingosine 1-phosphate is released from the cytosol of rat platelets in a carrier-mediated manner
Journal of Lipid Research, 2006 Sphingosine 1-phosphate (S1P) is accumulated in platelets and released on stimulation by thrombin or Ca2+. Thrombin-stimulated S1P release was inhibited by staurosporin, whereas Ca2+-stimulated release was not.
Nobuyoshi Kobayashi +6 more
doaj +1 more source
Activity-dependent adenosine release may be linked to activation of Na+-K+ ATPase : an in vitro rat study [PDF]
, 2014 In the brain, extracellular adenosine increases as a result of neuronal activity. The mechanisms by which this occurs are only incompletely understood. Here we investigate the hypothesis that the Na+ influxes associated with neuronal signalling activate ...
Sims, Robert E. +6 more
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The thermodynamics of metabolism, cardiovascular performance and exercise, in health and diabetes: The objective of clinical markers [PDF]
, 2013 Extensive experience in UK National Health Service metabolic syndrome/type 2 diabetes clinics highlights the need for convenient clinical marker(s) which can be readily used to indicate the success or otherwise of alternative therapies.
König, CS +4 more
core +6 more sources
Purinergic responses of chondrogenic stem cells to dynamic loading [PDF]
Journal of the Serbian Chemical Society, 2013 In habitually loaded tissues, dynamic loading can trigger ATP (adenosine 5’- triphosphate) release to extracellular environment, and result in calcium signaling via ATP binding to purine P2 receptors1.
Gađanski Ivana +1 more
doaj +1 more source
Sympathetic nerve-derived ATP regulates renal medullary blood flow via vasa recta pericytes [PDF]
, 2013 Pericyte cells are now known to be a novel locus of blood flow control, being able to regulate capillary diameter via their unique morphology and expression of contractile proteins. We have previously shown that exogenous ATP causes constriction of vasa
Peppiatt-Wildman, C. M. +12 more
core +1 more source