Results 11 to 20 of about 1,837,538 (297)
International Journal of Molecular Sciences, 2018 Adenosine triphosphate (ATP) has been well established as an important extracellular ligand of autocrine signaling, intercellular communication, and neurotransmission with numerous physiological and pathophysiological roles.
Akiyuki Taruno
core +3 more sources
Exocytosis of ATP from astrocytes modulates phasic and tonic inhibition in the neocortex. [PDF]
PLoS Biology, 2014 Communication between neuronal and glial cells is important for many brain functions. Astrocytes can modulate synaptic strength via Ca(2+)-stimulated release of various gliotransmitters, including glutamate and ATP.
Ulyana Lalo +5 more
doaj +3 more sources
Learning the ABCs of ATP release. [PDF]
J Biol Chem, 2020 ATP plays important roles outside the cell, but the mechanism by which it is arrives in the extracellular environment is not clear. Dunn et al now show that decreases in cellular cholesterol levels mediated by the ABCG1 transporter increase ATP release by volume-regulated anion channels under hypotonic conditions.
Libby AE, Jones B, Levi M.
europepmc +3 more sources
ATP Release Drives Inflammation with Lysophosphatidylcholine [PDF]
ImmunoHorizons, 2020 Abstract Lysophosphatidylcholine (LPC), a dominant lipid component of oxidized low-density lipoprotein, plays a major role in inflammation associated with atherosclerosis and neurodegenerative disorders. It activates inflammatory responses from macrophages, neuronal cells, and endothelial cells.
Sana, Ismaeel, Ayub, Qadri
openaire +3 more sources
ATP‐induced ATP release from astrocytes [PDF]
Journal of Neurochemistry, 2003 AbstractPropagation of interastrocyte Ca2+waves is mediated by diffusion of extracellular adenosine triphosphate (ATP), and may require regenerative release of ATP. The ability of ATP to initiate release of intracellular ATP was assessed by labeling adenine nucleotide pools in astrocyte cultures with14C‐adenine.
Christopher M, Anderson +2 more
openaire +2 more sources
Kinetics of urothelial ATP release [PDF]
American Journal of Physiology-Renal Physiology, 2006 Recent reports have proposed that the urothelium can sense mechanical stretch and communicate this information to sensory afferent neurons by the release of ATP into the vicinity of P2X-containing neurons. This report investigates the bidirectional release of ATP by in vitro rabbit urothelium.
Simon A, Lewis, Jamie R, Lewis
openaire +2 more sources
Quantal Release of ATP in Mouse Cortex [PDF]
The Journal of General Physiology, 2007 Transient currents occur at rest in cortical neurones that reflect the quantal release of transmitters such as glutamate and γ-aminobutyric acid (GABA). We found a bimodal amplitude distribution for spontaneously occurring inward currents recorded from mouse pyramidal neurones in situ, in acutely isolated brain slices superfused with picrotoxin. Larger
Pankratov, Yuriy +3 more
openaire +3 more sources
Mitochondria regulate TRPV4‐mediated release of ATP [PDF]
British Journal of Pharmacology, 2021 Background and PurposeCa2+influx via TRPV4 channels triggers Ca2+release from the IP3‐sensitive internal store to generate repetitive oscillations. Although mitochondria are acknowledged regulators of IP3‐mediated Ca2+release, how TRPV4‐mediated Ca2+signals are regulated by mitochondria is unknown.
Zhang, Xun +4 more
openaire +5 more sources
Physiological Reports, 2021 The release of ATP from the epithelium of the urinary bladder (urothelium) in response to mechanical/chemical stimuli contributes to the visceral sensation in the micturition reflex.
Eriko Okuyama +5 more
doaj +1 more source
Taking a close look at a large-pore channel
eLife, 2020 The structure of pannexin 1, a channel protein with a large pore, has been determined for the first time.
Pablo S Gaete, Jorge E Contreras
doaj +1 more source