Results 11 to 20 of about 331,724 (261)
Air-stimulated ATP release from keratinocytes occurs through connexin hemichannels. [PDF]
PLoS ONE, 2013 Cutaneous ATP release plays an important role in both epidermal stratification and chronic pain, but little is known about ATP release mechanisms in keratinocytes that comprise the epidermis.
Travis P Barr +5 more
doaj +1 more source
ATP release from vascular endothelia occurs across Cx43 hemichannels and is attenuated during hypoxia. [PDF]
PLoS ONE, 2008 Extracellular ATP is an important signaling molecule for vascular adaptation to limited oxygen availability (hypoxia). Here, we pursued the contribution of vascular endothelia to extracellular ATP release under hypoxic conditions.We gained first insight ...
Marion Faigle +4 more
doaj +1 more source
Lytic Release of Cellular ATP: Physiological Relevance and Therapeutic Applications
Life, 2021 The lytic release of ATP due to cell and tissue injury constitutes an important source of extracellular nucleotides and may have physiological and pathophysiological roles by triggering purinergic signalling pathways.
Ryszard Grygorczyk +7 more
doaj +1 more source
Quantal Release of ATP in Mouse Cortex [PDF]
The Journal of General Physiology, 2007 Transient currents occur at rest in cortical neurones that reflect the quantal release of transmitters such as glutamate and γ-aminobutyric acid (GABA). We found a bimodal amplitude distribution for spontaneously occurring inward currents recorded from mouse pyramidal neurones in situ, in acutely isolated brain slices superfused with picrotoxin. Larger
Pankratov, Yuriy +3 more
openaire +3 more sources
Mitochondria regulate TRPV4‐mediated release of ATP [PDF]
British Journal of Pharmacology, 2021 Background and PurposeCa2+influx via TRPV4 channels triggers Ca2+release from the IP3‐sensitive internal store to generate repetitive oscillations. Although mitochondria are acknowledged regulators of IP3‐mediated Ca2+release, how TRPV4‐mediated Ca2+signals are regulated by mitochondria is unknown.
Zhang, Xun +4 more
openaire +5 more sources
Metabolites, 2022 Adenosine 5′-triphosphate (ATP) is released in the bladder lumen during filling. Urothelial ATP is presumed to regulate bladder excitability. Urinary ATP is suggested as a urinary biomarker of bladder dysfunctions since ATP is increased in the urine of ...
Alejandro Gutierrez Cruz +4 more
doaj +1 more source
Physiological Reports, 2021 The release of ATP from the epithelium of the urinary bladder (urothelium) in response to mechanical/chemical stimuli contributes to the visceral sensation in the micturition reflex.
Eriko Okuyama +5 more
doaj +1 more source
Taking a close look at a large-pore channel
eLife, 2020 The structure of pannexin 1, a channel protein with a large pore, has been determined for the first time.
Pablo S Gaete, Jorge E Contreras
doaj +1 more source
Metabolites, 2019 This study aimed to assess the effect of training loads on plasma adenosine triphosphate responsiveness in highly trained athletes in a 1 y cycle. Highly trained futsal players (11 men, age range 20−31 y), endurance athletes (11 men, age range 18 ...
Ewa Anna Zarębska +4 more
doaj +1 more source
International Journal of Molecular Sciences, 2018 Adenosine triphosphate (ATP) has been well established as an important extracellular ligand of autocrine signaling, intercellular communication, and neurotransmission with numerous physiological and pathophysiological roles. In addition to the classical exocytosis, non-vesicular mechanisms of cellular ATP release have been demonstrated in many cell ...
openaire +2 more sources