Results 11 to 20 of about 345,136 (302)
International Journal of Molecular Sciences, 2018 Adenosine triphosphate (ATP) has been well established as an important extracellular ligand of autocrine signaling, intercellular communication, and neurotransmission with numerous physiological and pathophysiological roles. In addition to the classical exocytosis, non-vesicular mechanisms of cellular ATP release have been demonstrated in many cell ...
Akiyuki Taruno
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Light-induced ATP release from the lens [PDF]
Purinergic Signalling, 2018 The recent discovery of the photoreceptor melanopsin in lens epithelial cells has opened the possibility of modulating this protein by light stimulation. Experiments carried out on New Zealand white rabbits have demonstrated that the release of ATP from the lens to the aqueous humor can be reduced either when a yellow filter or a melanopsin antagonist ...
Pintor Just, Jesús Jerónimo
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Mechanisms of constitutive and ATP-evoked ATP release in neonatal mouse olfactory epithelium
BMC Neuroscience, 2012 Background ATP is an extracellular signaling molecule with many ascribed functions in sensory systems, including the olfactory epithelium. The mechanism(s) by which ATP is released in the olfactory epithelium has not been investigated.
Hayoz Sébastien, Jia Cuihong, Hegg CC
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Diacylglycerol Signaling Underlies Astrocytic ATP Release [PDF]
Neural Plasticity, 2011 Astrocytes have the ability to modulate neuronal excitability and synaptic transmission by the release of gliotransmitters. The importance of ATP released downstream of the activation of Gq-coupled receptors has been well established, but the mechanisms ...
Alison E. Mungenast
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Negative-feedback regulation of ATP release: ATP release from cardiomyocytes is strictly regulated during ischemia [PDF]
Biochemical and Biophysical Research Communications, 2011 Extracellular ATP acts as a potent agonist on cardiomyocytes, inducing a broad range of physiological responses via P2 purinoceptors. Its concentration in the interstitial space within the heart is elevated during ischemia or hypoxia due to its release from a number of cell types, including cardiomyocytes.
Kunugi, Satohiko +4 more
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P2Y Receptor Modulation of ATP Release in the Urothelium [PDF]
BioMed Research International, 2014 The release of ATP from the urothelium in response to stretch during filling demonstrates the importance of the purinergic system for the physiological functioning of the bladder. This study examined the effect of P2 receptor agonists on ATP release from two urothelial cell lines (RT4 and UROtsa cells).
Mansfield, Kylie, Hughes, Jessica
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Learning the ABCs of ATP release. [PDF]
J Biol Chem, 2020 ATP plays important roles outside the cell, but the mechanism by which it is arrives in the extracellular environment is not clear. Dunn et al now show that decreases in cellular cholesterol levels mediated by the ABCG1 transporter increase ATP release by volume-regulated anion channels under hypotonic conditions.
Libby AE, Jones B, Levi M.
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ATP Release Drives Inflammation with Lysophosphatidylcholine [PDF]
ImmunoHorizons, 2020 Abstract Lysophosphatidylcholine (LPC), a dominant lipid component of oxidized low-density lipoprotein, plays a major role in inflammation associated with atherosclerosis and neurodegenerative disorders. It activates inflammatory responses from macrophages, neuronal cells, and endothelial cells.
Sana, Ismaeel, Ayub, Qadri
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ATP‐induced ATP release from astrocytes [PDF]
Journal of Neurochemistry, 2003 AbstractPropagation of interastrocyte Ca2+waves is mediated by diffusion of extracellular adenosine triphosphate (ATP), and may require regenerative release of ATP. The ability of ATP to initiate release of intracellular ATP was assessed by labeling adenine nucleotide pools in astrocyte cultures with14C‐adenine.
Christopher M, Anderson +2 more
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Kinetics of urothelial ATP release [PDF]
American Journal of Physiology-Renal Physiology, 2006 Recent reports have proposed that the urothelium can sense mechanical stretch and communicate this information to sensory afferent neurons by the release of ATP into the vicinity of P2X-containing neurons. This report investigates the bidirectional release of ATP by in vitro rabbit urothelium.
Simon A, Lewis, Jamie R, Lewis
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