In this article, I reflect on research on two ATPases. The first is F(1)F(0)-ATPase, also known as ATP synthase. It is the terminal enzyme in oxidative phosphorylation and famous as a nanomotor. Early work on mitochondrial enzyme involved purification in large amount, followed by deduction of subunit composition and stoichiometry and determination of ...
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Mitochondrial F(1)-ATPase contains a hexamer of alternating alpha and beta subunits. The assembly of this structure requires two specialized chaperones, Atp11p and Atp12p, that bind transiently to beta and alpha. In the absence of Atp11p and Atp12p, the hexamer is not formed, and alpha and beta precipitate as large insoluble aggregates.
Ludlam, Anthony +5 more
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Mechanism of action of cisplatin on Na+/K+ ATPase of Caco-2 colon cells in vitro. [PDF]
Mourad R, Hodeify R, Kreydiyyeh S.
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Structures of the 26<i>S</i> proteasome in complex with the Hsp70 co-chaperone Bag1 reveal a mechanism for direct substrate transfer. [PDF]
Maestro-López M +10 more
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The potential causes of myasthenia and fasciculations in severely ill ME/CFS patients: the role of disturbed electrophysiology. [PDF]
Wirth KJ, Steinacker JM.
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WDR72 Is Required for Urinary Acidification and Normal H<sup>+</sup>-ATPase Activity in Intercalated Cells in Mice. [PDF]
Auwerx H +4 more
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A New Case of a Neurodevelopmental Disorder and Myoclonic Dystonia Associated with the C.1404del Variant of the <i>ATP5F1A</i> Gene. [PDF]
Krastev G, Danis M.
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Dynamic balance of myoplasmic energetics, redox state and protons in a fast-twitch oxidative glycolytic skeletal muscle fibre. [PDF]
Disch J +4 more
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Vacuolar ATPase regulates ureteric bud branching morphogenesis during kidney development. [PDF]
Yosypiv IV, Liu H, Nakhoul NL.
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