Results 101 to 110 of about 615,643 (389)

Oxidative stress (glutathionylation) and Na,K-ATPase activity in rat skeletal muscle. [PDF]

PLoS ONE, 2014
Changes in ion distribution across skeletal muscle membranes during muscle activity affect excitability and may impair force development. These changes are counteracted by the Na,K-ATPase. Regulation of the Na,K-ATPase is therefore important for skeletal
Carsten Juel
doaj   +1 more source

Mapping the H+ (V)-ATPase interactome: identification of proteins involved in trafficking, folding, assembly and phosphorylation

Scientific Reports, 2015
V-ATPases (H+ ATPases) are multisubunit, ATP-dependent proton pumps that regulate pH homeostasis in virtually all eukaryotes. They are involved in key cell biological processes including vesicle trafficking, endosomal pH sensing, membrane fusion and ...
M. Merkulova, T. Paunescu, Anie Azroyan, V. Marshansky, S. Breton, Dennis Brown   +5 more
semanticscholar   +1 more source

Effect of Nanoparticle Rigidity on the Interaction of Stromal Membrane Particles with Leukemia Cells

Advanced Healthcare Materials, EarlyView.
Cell membrane nanoparticles made with stromal cells are prepared and used to target leukemia cells. Deposition of the cell membrane onto rigid silica cores leads to increased uptake both in leukemia cell lines and primary cells from patients. These results show that nanoparticle rigidity affects the interaction between cell membrane nanoparticles and ...
Sander de Weerd, Xinyu Ma, Zahra Zohali, Lieve L. Oudejans, Emmanouil Kyrloglou, Marc. C. A. Stuart, Wouter H. Roos, Jan Jacob Schuringa, Anna Salvati   +8 more
wiley   +1 more source

Artesunate Nanoplatform Targets the Serine–MAPK Axis in Cancer‐Associated Fibroblasts to Reverse Photothermal Resistance in Triple‐Negative Breast Cancer

Advanced Materials, EarlyView.
The artesunate nanoplatform selectively targets ECM CAF, functioning as a GTPase inhibitor through disruption of intracellular serine homeostasis. This metabolic intervention effectively suppresses MAPK cascade activity, which consequently inhibits PTT‐induced CAF to ECM CAF differentiation.
Dongdong Zheng, Jiaqi Yan, Xuejiao Liu, Zhiming Zhang, Anqi Jin, Yue Zhao, Lu Bai, Mengyao Quan, Xiuzhu Qi, Bin Fu, Zhigang Wu, Jin Zhou, Han Han, Ziqi Wang, Shiyu Wang, Chaoqiang Deng, Weijian Sun, Cai Chang, Shichong Zhou, Hongbo Zhang   +19 more
wiley   +1 more source

Parkinson’s disease-associated ATP13A2/PARK9 functions as a lysosomal H+,K+-ATPase

Nature Communications, 2023
Mutations in the human ATP13A2 (PARK9), a lysosomal ATPase, cause Kufor-Rakeb Syndrome, an early-onset form of Parkinson’s disease (PD). Here, we demonstrate that ATP13A2 functions as a lysosomal H+,K+-ATPase.
Takuto Fujii, Shushi Nagamori, Pattama Wiriyasermkul, Shizhou Zheng, Asaka Yago, Takahiro Shimizu, Yoshiaki Tabuchi, Tomoyuki Okumura, Tsutomu Fujii, Hiroshi Takeshima, Hideki Sakai   +10 more
doaj   +1 more source

Expansion of Thaumarchaeota habitat range is correlated with horizontal transfer of ATPase operons. [PDF]

, 2019
Thaumarchaeota are responsible for a significant fraction of ammonia oxidation in the oceans and in soils that range from alkaline to acidic. However, the adaptive mechanisms underpinning their habitat expansion remain poorly understood.
Bartlett, Douglas H, Eloe-Fadrosh, Emiley A, Hall, Richard, Han, Ping, Heiner, Cheryl, Herbold, Craig W, Huang, Li, Ingalls, Anitra E, Ji, Junbin, Jia, Zhongjun, Jung, Man-Young, Li, Meng, Liu, Linmeng, Liu, Yang, Lu, Lu, Martens-Habbena, Willm, Qin, Wei, Ren, Yi, Rhee, Sung-Keun, Stahl, David A, Wagner, Michael, Wang, Baozhan, Yan, Xin, Zheng, Yue, Zhou, Xue   +24 more
core   +2 more sources

Apical endosomes isolated from kidney collecting duct principal cells lack subunits of the proton pumping ATPase. [PDF]

, 1992
Endocytic vesicles that are involved in the vasopressin-stimulated recycling of water channels to and from the apical membrane of kidney collecting duct principal cells were isolated from rat renal papilla by differential and Percoll density gradient ...
Ausiello, DA, Brown, D, Gluck, S, Sabolić, I, Shi, LB, Verkman, AS, Wuarin, F   +6 more
core  

GelMA/AgNWs Hydrogel Combined with Electrical Stimulation Effectively Promotes Skin Wound Healing

Advanced Materials Interfaces, EarlyView.
The doped AgNWs in GelMA hydrogel prevent the wound from being infected and introduce the electrical field into the wound region. COMSOL simulation guides the introduced electric field to be conducive to promoting cell migration and proliferation. Thus, the GelMA/AgNWs hydrogel combined with ES effectively accelerated the healing process of skin wounds.
Xiaoxuan Hou, Yujie Wang, Mengni Zhu, Jie Zhang, Hongxin Qi, Min Xu, Xianghui Wang   +6 more
wiley   +1 more source

Control of calcium homeostasis in Schistosoma mansoni

Memorias do Instituto Oswaldo Cruz, 2001
Calcium signalling is fundamental for muscular contractility of Schistosoma mansoni. We have previously described the presence of transport ATPases (Na+,K+-ATPase and (Ca2+-Mg2+)-ATPase) and calcium channels (ryanodine receptors - RyR) involved in ...
F Noël, VMN Cunha, CLM Silva, DL Mendonça-Silva   +3 more
doaj   +1 more source

A High‐Throughput AngioPlate Platform with Integrated AngioTEER for Modeling and Monitoring Renal Proximal Tubule Injury

Advanced Materials Technologies, EarlyView.
Renal tubular injury is a major contributor to kidney disease, yet remains poorly understood due to the lack of predictive models. This study presents a high‐throughput 3D renal proximal tubule model on the AngioPlate platform integrated with automated TEER measurements (AngioTEER), enabling real‐time monitoring of drug‐induced nephrotoxicity ...
Shravanthi Rajasekar, Anushree Chakravarty, Kimia Asadi Jozani, Brenda Truong, Matana Hendrickson, Ahmed Attia, Muna Sabouny, Anna Basatskaya, Sergi Clotet‐Freixas, Madeleine Ludlow, Alexander Sotra, Dawn S. Y. Lin, Feng Zhang, Boyang Zhang   +13 more
wiley   +1 more source