Results 11 to 20 of about 615,643 (389)
Vacuolar ATPase as a potential therapeutic target and mediator of treatment resistance in cancer
Cancer Medicine, 2018 Vacuolar ATPase (V‐ATPase) is an ATP‐dependent H+‐transporter that pumps protons across intracellular and plasma membranes. It consists of a large multi‐subunit protein complex and influences a wide range of cellular processes.
Bradleigh Whitton +3 more
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The curious case of vacuolar ATPase: regulation of signaling pathways
Molecular Cancer, 2018 The Vacuolar ATPase (V-ATPase) is a proton pump responsible for controlling the intracellular and extracellular pH of cells. The structure of V-ATPase has been highly conserved among all eukaryotic cells and is involved in diverse functions across ...
Sahithi Pamarthy +3 more
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Transcriptional regulators of Na, K-ATPase subunits
Frontiers in Cell and Developmental Biology, 2015 The Na,K-ATPase classically serves as an ion pump creating an electrochemical gradient across the plasma membrane that is essential for transepithelial transport, nutrient uptake and membrane potential.
Zhiqin eLi, Sigrid A Langhans
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Molecular basis of V-ATPase inhibition by bafilomycin A1
Nature Communications, 2021 Pharmacological inhibition of vacuolar-type H+-ATPase (V-ATPase) by its specific inhibitor can abrogate tumor metastasis, prevent autophagy, and reduce cellular signaling responses.
Rong Wang +5 more
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Translational Neurodegeneration, 2020 Lysosomes digest extracellular material from the endocytic pathway and intracellular material from the autophagic pathway. This process is performed by the resident hydrolytic enzymes activated by the highly acidic pH within the lysosomal lumen. Lysosome
Qiaoyun Song +3 more
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The endoplasmic reticulum P5A-ATPase is a transmembrane helix dislocase
Science, 2020 Dissecting membrane dislocation Mistargeting and misinsertion of membrane proteins causes proteostasis stress and dysfunction of intracellular organelles, which can lead to disease. McKenna et al.
Michael J. McKenna +6 more
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The H+-ATPase (V-ATPase): from proton pump to signaling complex in health and disease
American Journal of Physiology - Cell Physiology, 2020 A primary function of the H+-ATPase (or V-ATPase) is to create an electrochemical proton gradient across eukaryotic cell membranes, which energizes fundamental cellular processes.
A. Eaton, M. Merkulova, Dennis Brown
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Isolation of oligomycin-sensitive adenosine triphosphatase from beef heart mitochondria and analysis of its fine structure [PDF]
, 1967 1. An oligomycin -sensitive ATPase was isolated and partially purified from beef heart mitochondria. The specific activity of ATPase sensitive to oligomycin of the fraction was five to eight times that of aged mitochondrial or of DNP-induced ...
Hayashi, Hideo +4 more
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Proceedings of the National Academy of Sciences of the United States of America, 1990 Thapsigargin, a tumor-promoting sesquiterpene lactone, discharges intracellular Ca2+ in rat hepatocytes, as it does in many vertebrate cell types. It appears to act intracellularly, as incubation of isolated rat liver microsomes with thapsigargin induces
O. Thastrup +4 more
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Bafilomycins and concanamycins as inhibitors of V-ATPases and P-ATPases [PDF]
Journal of Experimental Biology, 1997 ABSTRACT Bafilomycins and concanamycins, two groups of the plecomacrolide-defined class of macrolide antibiotics, have recently been recognized as important tools for studying the physiological role of vacuolar-type, proton-translocating ATPases (V-ATPases) and ATPases with phosphorylated states (P-ATPases) in animal and plant cells as ...
Karlheinz Altendorf, Stefan Dröse
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