Results 41 to 50 of about 1,791 (153)

Deciphering the catalytic and pharmacological mechanisms of Coptis chinensis herbzymes to renovate intestinal microenvironment for colitis alleviation

BMEMat, Volume 4, Issue 2, June 2026.
The synthesized CCzymes possess both antioxidant enzyme activity and pharmacological properties inherent to Coptis chinensis. By their antioxidant enzyme activity, CCzymes can attenuate oxidative stress within the inflammatory region of ulcerative colitis (UC), while their pharmacological activity acts on macrophage polarization and the intestinal ...
Zhichao Deng, Can Li, Yujie Zhang, Yuanyuan Zhu, Chenxi Xu, Bowen Gao, Mingxin Zhang, Martina H. Stenzel, Kelong Fan, Mingzhen Zhang, Yanyan Jiang   +10 more
wiley   +1 more source

A Systematic Review on Functional Bioactive Compound Atractylone: Natural Source, Pharmacological Properties and Mechanisms Insights

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Atractylone exhibits diverse pharmacological effects, including anticancer and neuroprotection. A systematic review was conducted following PRISMA guidelines to analyze Atractylone. This study explores Atractylone's sources, biosynthesis, and therapeutic potential.
Hamza Elhrech, Oumayma Aguerd, Meriem El Fessikh, Zouhair Essahli, Taoufiq Benali, Waleed Al Abdulmonem, Learn‐Han Lee, Imane Chamkhi, Abdelhakim Bouyahya   +8 more
wiley   +1 more source

Yiqi Daozhi Formula Reduces the M1 Polarization of Macrophages in Mice With Postoperative Ileus Through Mediating Glycolysis Metabolism

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
ABSTRACT Background Postoperative ileus (POI) represents a disorder of gastrointestinal function following surgical procedures, characterized by a multifaceted etiology. There is an urgent clinical need to search for treatment regimens that improve the therapeutic effect for POI.
Wang Gang, Zhao Xuan, Wang Ye, Yi Chen, Yu Jing, Zhang Tianle, Shao Mingyue, Tao Yuewei, Jiang Zhiwei   +8 more
wiley   +1 more source

Therapeutic effect of Yupingfeng powder and its bioactive metabolites on renal diseases

Frontiers in Pharmacology
Yupingfeng powder (YPFP), also known as Yupingfeng San, is a traditional Chinese medicine (TCM) formula comprising Astragali Radix, Saposhnikoviae Radix, and Atractylodis Macrocephalae Rhizoma, and is used clinically to treat renal diseases in China ...
Yuxin Bai, Zhanhong Cao, Yue Shen, Chen Zhang, Xiaofan Yang   +4 more
doaj   +1 more source

Anti-tumor effects of Atractylenolide I on bladder cancer cells

Journal of Experimental & Clinical Cancer Research, 2016
Background Atractylenolide I (ATR-1), an active component of Rhizoma Atractylodis Macrocephalae, possesses cytotoxicity against various carcinomas. However, little is known about the effects of ATR-1on bladder cancer. In the present study, the anti-tumor
Rui Yu, Bi-xia Yu, Jun-feng Chen, Xiu-yi Lv, Ze-jun Yan, Yue Cheng, Qi Ma   +6 more
doaj   +1 more source

Is there a role for traditional and complementary medicines in managing chronic fatigue? a systematic review of randomized controlled trials

Frontiers in Pharmacology, 2023
Introduction: Chronic fatigue syndrome (CFS) is an increasingly common condition that is challenging to treat due to unclear etiology and a lack of consensus on clinical diagnosis and treatment guidance. Many affected people resorted to using traditional
Yuxiao Li, Jingya Yang, Chi Ian Chau, Junnan Shi, Xianwen Chen, Hao Hu, Hao Hu, Carolina Oi Lam Ung, Carolina Oi Lam Ung   +8 more
doaj   +1 more source

AIE‐Mediated In Situ Monitoring of Protein Aggregates During Coagulation and Screening of Anticoagulant Agents

Aggregate, Volume 7, Issue 1, January 2026.
The process of screening active monomers via BioSTAS technology. (A) Analyzing the properties and luminescence mechanism of an AIE molecule through density functional theory and MD simulation. (B) The establishment of a screening model, including biosensing and affinity chromatography. (C) Screening and identification of active substances.
Shuxian Zhang, Hui Yuan, Lingling Yang, Xiaoxuan Fan, Keshuai Liu, Rui Mai, Wangyan Zhao, Cheng Liu, Qiang Han, Yongjian Ai, Qionglin Liang, Xueqin Ma, Guoning Chen   +12 more
wiley   +1 more source

Medication rule and mechanism of traditional Chinese medicine in treating metabolism-associated fatty liver disease based on bioinformatics technology

Digital Chinese Medicine, 2023
[Abstract]: [Objective]: To analyze the main syndrome types, medication rules, and core prescription characteristics of traditional Chinese medicine (TCM) in the treatment of metabolism-associated fatty liver disease (MAFLD), and to predict the anti ...
Zhang Yunkun, Yao Rong, Li Lin, Li Wenli, Li Changqing, Pan Yu, Li Shunxiang   +6 more
doaj   +1 more source

Yifei Decoction Regulates the NGF/TRKA/PI3K/AKT Signaling Axis to Inhibit the Epithelial–Mesenchymal Transformation and Proliferation of Pulmonary Epithelial Cells in Bleomycin‐Induced Pulmonary Fibrogenesis

Canadian Respiratory Journal, Volume 2026, Issue 1, 2026.
Background It was important to find better therapeutic drugs for idiopathic pulmonary fibrosis (IPF), and in our previous study, Yifei decoction (YFT) alleviated IPF. A deeper understanding of its mechanisms of action could aid in the development of novel treatment strategies.
Lijuan Chen, Chengzhong Lan, Xiangli Deng, Mei Wu, Mei Shao, Mei Yang, Xinwen Ma, Fen Huang, Haiyin Wu, Lipi Buch   +9 more
wiley   +1 more source

From “Monarch, Minister, Assistant, and Envoy” to “Microbial Dialogue”: A Review of Novel Mechanisms by Which Chinese Herb Pairs Improve Metabolic Diseases Through Gut Microbiota Metabolic Regulation

Gastroenterology Research and Practice, Volume 2026, Issue 1, 2026.
Metabolic diseases, including obesity, Type 2 diabetes, and nonalcoholic fatty liver disease, have become a severe global health burden, and their pathogenesis is closely associated with gut microbiota dysbiosis. As the core unit of traditional Chinese medicine (TCM) compatibility theory, Chinese herb pairs possess unique advantages in metabolic ...
Zeyu Wang, Palash Mandal
wiley   +1 more source