Results 101 to 110 of about 934,412 (371)

Integrative Omics Defines Metabolic Biomarkers and Genetic Regulatory Mechanisms of Mortality Risk

Advanced Science, EarlyView.
Understanding mortality mechanisms remains a fundamental challenge. Through multi‐omics analysis of a three‐generation chicken model, are identified 45,585 mQTLs and establish a 16‐metabolite predictor of mortality. An inflammation‐growth trade‐off and evolutionarily conserved pathways involving butyrate–microbiota interactions and L‐cysteine's dual ...
Peihao Liu, Bingxing An, Jumei Zheng, Qiao Wang, Zhirui Yang, Zhengda Li, Dawei Liu, Fan Ying, Jie Wen, Lingzhao Fang, Guiping Zhao   +10 more
wiley   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

Alcohol Abstinence in Drinkers with Atrial Fibrillation.

New England Journal of Medicine, 2020
BACKGROUND Excessive alcohol consumption is associated with incident atrial fibrillation and adverse atrial remodeling; however, the effect of abstinence from alcohol on secondary prevention of atrial fibrillation is unclear.
A. Voskoboinik, J. Kalman, Anurika De Silva, T. Nicholls, B. Costello, S. Nanayakkara, S. Prabhu, D. Stub, S. Azzopardi, D. Vizi, G. Wong, C. Nalliah, H. Sugumar, Michael C. G. Wong, E. Kotschet, D. Kaye, A. Taylor, P. Kistler   +17 more
semanticscholar   +1 more source

Detection of atrial fibrillation episodes in long-term heart rhythm signals using a support vector machine [PDF]

, 2020
Atrial fibrillation (AF) is a serious heart arrhythmia leading to a significant increase of the risk for occurrence of ischemic stroke. Clinically, the AF episode is recognized in an electrocardiogram.
Czabanski, Robert, Horoba, Krzysztof, Jezewski, Janusz, Jezewski, Michal, Kahánková, Radana, Kupka, Tomasz, Leski, Jacek M., Martinek, Radek, Matonia, Adam, Wrobel, Janusz   +9 more
core   +1 more source

Mitochondrial Adaptation to Mechanical Stress in Cardiac Ageing and Disease

Advanced Science, EarlyView.
Mechanical forces shape the heart's energy factories. This review explores how mitochondria in cardiac cells sense and respond to biomechanical stress, altering their structure, positioning, and metabolism. By linking mechanical cues to mitochondrial adaptation, the article highlights pathways driving heart disease and points to new strategies for ...
Aishwarya Prakash, Thomas Iskratsch
wiley   +1 more source

ABC of Atrial Fibrillation: DRUGS FOR ATRIAL FIBRILLATION [PDF]

BMJ, 1995
One of the most important principles of using antiarrhythmic drugs for controlling any arrhythmia is to treat only patients who are symptomatic, have malignant arrhythmias (such as ventricular fibrillation), or are haemodynamically compromised (for example, with hypotension or heart failure).
G Y, Lip, R D, Watson, S P, Singh
openaire   +2 more sources

Leucine‐Dependent SLC7A5–PGAM5 Interaction Promotes Advanced Atherosclerosis Through Hindering Mitochondrial Function of Macrophages

Advanced Science, EarlyView.
Higher plasma leucine is associated with increased risk of new‐onset myocardial infarction. Leucine deprivation alleviates advanced atherosclerosis in mice. Tumor‐induced leucine deprivation reprograms macrophage metabolism and increases CD5Lhi macrophages in mouse plaques. Mechanistically, leucine deficiency reduced SLC7A5‐PGAM5 binding in macrophages,
Shan Zhong, Xueyu Wang, Qingsong Li, Siqi Wang, Bin Sun, Wenjun Ni, Gengyu Zhou, Fan Wang, Xianwei Xie, Cheng Jin, Gang Xu, Peng Zhao, Xiang Peng, Feiyuan Han, Xiangwen Xi, Yidan Wang, Juan Xu, Yue Wang, Xia Gu, Shuo Li, Jian Zhang, Shuijie Li, Jinwei Tian   +22 more
wiley   +1 more source

Subtype of atrial fibrillation and the outcome of transcatheter aortic valve replacement: The FinnValve Study

PLoS ONE, 2020
Whether the subtype of atrial fibrillation affects outcomes after transcatheter aortic valve replacement for aortic stenosis is unclear. The nationwide FinnValve registry included 2130 patients who underwent primary after transcatheter aortic valve ...
Jussi Jaakkola, Samuli Jaakkola, K. E. Juhani Airaksinen, Annastiina Husso, Tatu Juvonen, Mika Laine, Marko Virtanen, Pasi Maaranen, Matti Niemelä, Timo Mäkikallio, Mikko Savontaus, Tuomas Tauriainen, Antti Valtola, Antti Vento, Markku Eskola, Peter Raivio, Fausto Biancari, Corstiaan den Uil   +17 more
doaj   +2 more sources

Atrial fibrillation and hyperthyroidism: A literature review

Indian Heart Journal, 2017
Atrial fibrillation is the most common arrhythmia worldwide with increasing frequency noted with age. Hyperthyroidism is a well-known cause of atrial fibrillation with a 16%–60% prevalence of atrial fibrillation in patients with known hyperthyroidism ...
Vivek Reddy, Wael Taha, Shanker Kundumadam, Mazhar Khan   +3 more
doaj   +1 more source

Time series kernel similarities for predicting Paroxysmal Atrial Fibrillation from ECGs [PDF]

, 2018
We tackle the problem of classifying Electrocardiography (ECG) signals with the aim of predicting the onset of Paroxysmal Atrial Fibrillation (PAF).
Bianchi, Filippo Maria, Ferrante, Alberto, Livi, Lorenzo, Malek, Miroslaw, Milosevic, Jelena   +4 more
core   +3 more sources