Results 21 to 30 of about 36,712 (243)

Presence of atrial natriuretic factor in normal and hyperplastic human prostate and its relationship with oxytocin localisation

European Journal of Histochemistry, 2009
In this work, we showed the presence of atrial natriuretic factor (ANF) in human prostate and compared its localisation in normal and hyperplastic conditions.
E Farina-Lipari, D Lipari, M Bellafiore, R Anzalone, F Cappello, B Valentino   +5 more
doaj   +1 more source

Natriuretic Peptide Receptor A as a Novel Target for Prostate Cancer

Molecular Cancer, 2011
Background The receptor for the cardiac hormone atrial natriuretic peptide (ANP), natriuretic peptide receptor A (NPRA), is expressed in cancer cells, and natriuretic peptides have been implicated in cancers. However, the direct role of NPRA signaling in
Kong Xiaoyuan, Hellermann Gary, Patel Ronil, Mohapatra Shyam S, Raulji Payal, Wang Xiaoqin, Vera Pedro L, Meyer-Siegler Katherine L, Coppola Domenico, Mohapatra Subhra   +9 more
doaj   +1 more source

Indoxyl sulfate induces left ventricular hypertrophy via the AhR-FGF23-FGFR4 signaling pathway

Frontiers in Cardiovascular Medicine, 2023
BackgroundPatients with chronic kidney disease (CKD) have a high risk of left ventricular hypertrophy (LVH). Fibroblast growth factor 23 (FGF23) and indoxyl sulfate (IS) are associated with LVH in patients with CKD, but the interactions between these ...
Hiroshi Kishimoto, Toshiaki Nakano, Kumiko Torisu, Masanori Tokumoto, Yushi Uchida, Shunsuke Yamada, Masatomo Taniguchi, Takanari Kitazono   +7 more
doaj   +1 more source

Plasma natriuretic peptides in children and adolescents with obstructive sleep apnoea and their changes following intervention

Frontiers in Pediatrics, 2014
Objective: This study aimed to evaluate circulating natriuretic peptides (NP) concentration in obese and non-obese children and adolescents with and without OSA, and their levels following OSA treatment.Methods: Subjects with habitual snoring and ...
Albert Martin Li, Chun T eAu, Jodie eZhu, Kate eChan, Michael eChan, Dennis eLee, Yun K eWing   +6 more
doaj   +1 more source

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source

Biomarkers for predicting atrial fibrillation: An explorative sub-analysis of the randomised SCREEN-AF trial

European Journal of General Practice
Background Atrial fibrillation (AF) is a common treatable risk factor for stroke. Screening for paroxysmal AF in general practice is difficult, but biomarkers might help improve screening strategies.Objectives We investigated six blood biomarkers for ...
Katharina Schmalstieg-Bahr, David J. Gladstone, Eva Hummers, Johanna Suerbaum, Jeff S. Healey, Antonia Zapf, Denise Köster, Stefanie M. Werhahn, Rolf Wachter   +8 more
doaj   +1 more source

The atrial natriuretic factor. [PDF]

Heart, 1986
In less than three years since the rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats was reported the factor responsible for the diuretic, natriuretic, and vasodilating activity of the atrial homogenates was isolated, its chemical structure elucidated, and its total synthesis achieved. Also the cDNA and
openaire   +2 more sources

The E3 Ligase RNF115 Aggravates Pathological Cardiac Hypertrophy via Ubiquitin‐Mediated Degradation of SPTBN1

Advanced Science, EarlyView.
In response to hypertrophic stimuli, increased c‑JUN phosphorylation upregulates RNF115, leading to SPTBN1 ubiquitination and degradation. which promotes F‑actin depolymerization and YAP activation, driving cardiac hypertrophy. The RNF115 inhibitor DTD effectively suppresses SPTBN1 ubiquitination and cardiac hypertrophy.
Yan Zu, Shiqing Chen, Ji Chen, Liuliu Ruan, Bowen Li, Weijian Chu, Shichen Huang, Dian Yu, Jing Tian, Yuhan Zhao, Yi Han, Xin Tang, Yong Ji   +12 more
wiley   +1 more source

Signs of left atrial disease and 10-year risk of atrial fibrillation.

PLoS ONE, 2022
BackgroundThe contribution of left atrial disease and excessive supraventricular ectopic activity (ESVEA) to the risk for incident atrial fibrillation (AF) is incompletely understood.ObjectiveTo analyse the ten-year risk to develop AF in patients with ...
Tobias Uhe, Tina Stegmann, Romy Langhammer, Nikolaos Dagres, Ulrich Laufs, Rolf Wachter   +5 more
doaj   +1 more source

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source